Patents Assigned to The General Hospital Corp.
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Patent number: 9441081Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.Type: GrantFiled: March 3, 2008Date of Patent: September 13, 2016Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 9433705Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: GrantFiled: September 25, 2013Date of Patent: September 6, 2016Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
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Patent number: 9370878Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: March 14, 2013Date of Patent: June 21, 2016Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 8968628Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: January 10, 2011Date of Patent: March 3, 2015Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 8866478Abstract: In a magnetic resonance apparatus and operating method therefor, and in a processor that is programmed to design RF pulses for operating such a magnetic resonance apparatus, the RF pulses are designed to mitigate off-resonance effects caused by inhomogeneity of the basic (B0) magnetic field in the magnetic resonance apparatus. The RF pulses of a parallel transmit array are designed with different spatial phase distributions, that deviate from a constant phase from pulse-to-pulse, with the absolute value of the difference between respective spatial phase distributions of any two successively radiated RF pulses corresponding to the off-resonance that is caused by B0-inhomogeneity during the time between the radiation of the successive pulses.Type: GrantFiled: July 13, 2011Date of Patent: October 21, 2014Assignees: Siemens Aktiengesellschaft, The General Hospital Corp., Massachusetts Institute of TechnologyInventors: Elfar Adalsteinsson, Hans-Peter Fautz, Kawin Setsompop, Lawrence Wald
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Patent number: 8805479Abstract: A system for determining a functional property of a moving object includes a tag contactable to the object such that the tag follows the movement of the object. The system further includes a movement determination device configured to determine the movement of the tag. The system also includes a functional property determination device configured to determine a functional property of the object from the determined movement of the tag.Type: GrantFiled: February 7, 2008Date of Patent: August 12, 2014Assignees: Koninklijke Philips N.V., The General Hospital Corp.Inventors: Robert Manzke, Raymond Chan, Vivek Reddy, Andre Luiz Buchele D'avila
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Patent number: 8337833Abstract: Methods of causing an improvement in central nervous system function are provided. The methods include administering an aliquot of stem cells to the patient, the cells being derived from blood, e.g., umbilical cord blood. In some cases a growth factor is administered with the cells.Type: GrantFiled: May 11, 2010Date of Patent: December 25, 2012Assignees: The General Hospital Corp., ViaCord, LLCInventors: Morey Kraus, Seth Finklestein, Paul Clark
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Patent number: 8212653Abstract: A system is provided for establishing a protected zone and monitoring interactions therewith. The system includes a protected zone designator and a wearable device. The protected zone designator establishes the protected zone. The protected zone designator is configured for placement at a location in which the protected zone is desired. The wearable device is separate and distal from the protected zone designator. The wearable device includes a protected zone recognition component configured to recognize the protected zone and identify pre-defined interaction criteria for the protected zone. Upon the wearable device entering the protected zone, the protected zone recognition component recognizes the protected zone and identifies the interaction criteria of the protected zone. Based on the interaction criteria the wearable device determines and records compliance with the interaction criteria.Type: GrantFiled: March 20, 2008Date of Patent: July 3, 2012Assignee: The General Hospital Corp.Inventors: Arthur L. Goldstein, Michael K. Dempsey, Ronald S. Newbower
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Patent number: 8164439Abstract: A system is provided for establishing a compliance zone and monitoring interactions therewith. The system includes a compliance zone designator and a wearable device. The compliance zone designator transmits an ultrasound signal to establish the compliance zone. The ultrasound signal may be encoded with information on the compliance zone. The compliance zone designator is configured for placement at a location in which the compliance zone is desired. The wearable device is separate from the compliance zone designator. The wearable device includes a compliance zone recognition component configured to recognize the compliance zone and identify one or more pre-defined interaction criteria for the compliance zone. When the wearable device is within the compliance zone, the compliance zone recognition component recognizes the compliance zone and identifies the interaction criteria of the compliance zone.Type: GrantFiled: June 18, 2009Date of Patent: April 24, 2012Assignee: The General Hospital Corp.Inventors: Michael K. Dempsey, Ronald S. Newbower
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Publication number: 20100321180Abstract: A system is provided for establishing a compliance zone and monitoring interactions therewith. The system includes a compliance zone designator and a wearable device. The compliance zone designator transmits an ultrasound signal to establish the compliance zone. The ultrasound signal may be encoded with information on the compliance zone. The compliance zone designator is configured for placement at a location in which the compliance zone is desired. The wearable device is separate from the compliance zone designator. The wearable device includes a compliance zone recognition component configured to recognize the compliance zone and identify one or more pre-defined interaction criteria for the compliance zone. When the wearable device is within the compliance zone, the compliance zone recognition component recognizes the compliance zone and identifies the interaction criteria of the compliance zone.Type: ApplicationFiled: June 18, 2009Publication date: December 23, 2010Applicant: THE GENERAL HOSPITAL CORP.Inventors: Michael K. DEMPSEY, Ronald S. Newbower
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Patent number: 7811557Abstract: Methods of causing an improvement in central nervous system function are provided. The methods include administering an aliquot of stem cells to the patient, the cells being derived from blood, e.g., umbilical cord blood. In some cases a growth factor is administered with the cells.Type: GrantFiled: October 27, 2000Date of Patent: October 12, 2010Assignees: Viacell, Inc., The General Hospital Corp.Inventors: Morey Kraus, Seth Finklestein, Paul Clark
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Patent number: 7655224Abstract: The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.Type: GrantFiled: October 12, 2006Date of Patent: February 2, 2010Assignees: Children's Medical Center Corp., The General Hospital Corp., Northeastern Ohio Universities COMInventors: Evan Y. Snyder, Xandra O. Breakefield, Karen S. Aboody, Ulrich Herrlinger, William P. Lynch
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Patent number: 7285573Abstract: The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer's disease, Parkinson's disease, stroke, Huntington's disease, amyotropic lateral sclerosis, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases.Type: GrantFiled: November 21, 2003Date of Patent: October 23, 2007Assignees: Avicena Group, Inc., The General Hospital Corp.Inventors: Rima Kaddurah-Daouk, Ghaleb Daouk, M. Flint Beal
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Patent number: 6998470Abstract: The present invention relates to a method of isolating and/or purifying hypothalamic inhibitory factor (HIF) from a sample (e.g., tissue fluid) containing HIF. The present invention provides for isolation of large amounts of HIF using diafiltration, solid phase extraction and immunoaffinity techniques. In one embodiment, the invention relates to a method of purifying hypothalamic inhibitory factor from a sample containing hypothalamic inhibitory factor comprising subjecting the sample to diafiltration, solid phase extraction and immunoaffintiy chromatography.Type: GrantFiled: February 17, 2000Date of Patent: February 14, 2006Assignees: Bion, Inc., The General Hospital Corp.Inventors: Rex T. Gallagher, Garner T. Haupert, Jr.
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Publication number: 20050208022Abstract: The invention provides compositions and methods of treating subjects afflicted with a photoreceptor disorder. Methods for treating a subject suffering from a disorder characterized by photoreceptor cell degeneration are provided, wherein a gene encoding a photosensitive protein is introduced into a retinal cell of a subject. In one aspect of the invention, the retinal cells which receive the photosensitive protein include non-photoreceptor cells such as horizontal cells, amacrine cells, bipolar cells, and ganglion cells.Type: ApplicationFiled: January 13, 2005Publication date: September 22, 2005Applicant: THE GENERAL HOSPITAL CORP.Inventor: Richard Masland
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Patent number: 6689936Abstract: The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.Type: GrantFiled: September 10, 1999Date of Patent: February 10, 2004Assignee: The General Hospital Corp.Inventors: Robert Burgeson, Satoshi Amano, Jiro Kishimoto, Toshio Nishiyama, Ritsuko Ehama
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Patent number: 6641617Abstract: A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.Type: GrantFiled: December 3, 1999Date of Patent: November 4, 2003Assignees: The General Hospital Corp., Massachusetts Institute of TechnologyInventors: Edward W. Merrill, William H. Harris, Murali Jasty, Orhun Muratoglu, Charles R. Bragdon, Daniel O. O'Connor, Premnath Venugopalan
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Patent number: 6558932Abstract: The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.Type: GrantFiled: November 3, 2000Date of Patent: May 6, 2003Assignee: The General Hospital Corp.Inventors: Mark C. Fishman, Tao P. Zhong
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Patent number: 6525018Abstract: Intestinal trefoil factors and nucleic acids encoding intestinal trefoil factors are disclosed. The intestinal trefoil factors disclosed are resistant to destruction in the digestive tract and can be used for the treatment of peptic ulcer diseases, inflammatory bowel diseases, eye disorders and other insults.Type: GrantFiled: May 17, 1999Date of Patent: February 25, 2003Assignee: The General Hospital Corp.Inventor: Daniel K. Podolsky
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Patent number: 6468791Abstract: The present invention discloses nucleic acid molecules encoding AD4 gene products, expression vectors and host cells suitable for expressing such gene products. Also disclosed are methods for treating, preventing, and diagnosing Alzheimer's Disease.Type: GrantFiled: August 16, 1999Date of Patent: October 22, 2002Assignees: The General Hospital Corp., University of WashingtonInventors: Rudolph E. Tanzi, Gerard D. Schellenberg, Wilma Wasco, Ephrat Levy-Lahad, Thomas D. Bird, David J. Galas