Patents Assigned to The General Hospital Corporation
  • Publication number: 20210293783
    Abstract: The present invention provides methods and compositions based on a non-naturally occurring nucleic acid construct encoding a fusion protein for quantitating levels of secretion in a single cell which may comprise a protein sequence which may comprise a cytoplasmic domain, a transmembrane domain and a vesicular domain, wherein the vesicular domain may comprise a protein tag sequence, wherein upon expression of the fusion protein by a cell, the fusion protein localizes to the membrane of a secretory vesicle such that the protein tag localizes to the lumen of the secretory vesicle, and wherein the protein tag binds to a cell-impermeable marker, whereby upon secretion of the contents of the secretory vesicle, the protein tag is exposed to the cell-impermeable marker, the fusion protein is recycled back into the cell, and the single cell becomes labeled with the marker relative to the amount of secretion.
    Type: Application
    Filed: April 17, 2018
    Publication date: September 23, 2021
    Applicants: THE GENERAL HOSPITAL CORPORATION, THE BROAD INSTITUTE, INC.
    Inventors: Sean Burns, Jason Wright, Thomas Sundberg
  • Patent number: 11125745
    Abstract: Target analyte detection devices include a housing having a potentiostat and a microcontroller coupled to the potentiostat. The device also includes a substrate having a plurality of electrodes on a first surface of the substrate. A first set of electrodes of the plurality of electrodes defines a first sample detection region. The substrate is removably attachable to the housing such that the first set of electrodes is coupled to the potentiostat upon attaching the substrate to the housing. The device also includes a magnet assembly couplable to a second surface of the substrate. The magnet assembly includes a magnet positioned in the magnet assembly such that a magnetic field from the magnet extends through the substrate and the first set of electrodes into an area above the first sample detection region upon coupling the magnet assembly to the substrate.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: September 21, 2021
    Assignees: The General Hospital Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Hakho Lee, Ralph Weissleder, Sangmoo Jeong, Jongmin Park, Cesar Castro, Hsing-Ying Lin, Jamil Azzi
  • Patent number: 11123047
    Abstract: A multi-modal catheter combining at least NIRF and IVUs imaging channels used to reveal integrated biological and structural features of a lumen intravascularly imaged through flowing blood in vivo and corrected for distance-related attenuation and/or scattering parameters of in vivo blood to compensate for discovered overestimation of the degree of in-vivo-blood attenuation of NIRF signal Enhancing the sensitivity of detection of vascular injury and/or plaque deposition beyond the capability of a standalone IVUS imaging as a result of the use of such corrected catheter.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: September 21, 2021
    Assignee: The General Hospital Corporation
    Inventors: Farouc A. Jaffer, Vasilis Ntziachristos
  • Publication number: 20210283155
    Abstract: A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
    Type: Application
    Filed: May 28, 2021
    Publication date: September 16, 2021
    Applicants: Children's Hospital Medical Center, The General Hospital Corporation d/b/a Massachusetts General Hospital, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Patent number: 11116819
    Abstract: The present invention relates to methods and compositions for mobilizing hematopoietic stem cells and/or progenitor cells, and related methods of conditioning for engraftment of transplanted hematopoietic stem cells and/or progenitor cells, and methods of treating diseases requiring hematopoietic stem cell and/or progenitor cell transplantation.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: September 14, 2021
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David T. Scadden, Borja Saez, Francesca Ferraro, Jonathan Hoggatt
  • Patent number: 11117858
    Abstract: Provided herein are radiolabeled compounds useful for minimally invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for position emission tomography imaging of voltage gated sodium channels. Methods for prepared unlabeled and labeled compounds, and diagnostic methods using the compounds are also provided.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: September 14, 2021
    Assignee: The General Hospital Corporation
    Inventors: Matthias Schoenberger, Jacob Hooker
  • Patent number: 11116862
    Abstract: A device for selectively providing an odor-rich environment includes a housing and a cover. The housing includes a central cavity and a plurality of chambers configured to store a predefined fragrance therein and having a respective outlet formed on an outer wall of the housing. The cover includes an exterior surface having at least one vent formed on the exterior surface. The exterior surface includes an interior sidewall and an exterior sidewall forming an inner chamber that slidably engages the housing such that the cover is configured to move between an open position and a closed position. Responsive to the cover being in the open position, the at least one vent is generally adjacent to the outlet of at least one of the plurality of chambers of the housing. The odor-rich environment can assist in preventing and/or treating postoperative delirium (POD) postoperative cognitive dysfunction (POCD), and/or pain in a subject.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: September 14, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventor: Zhongcong Xie
  • Patent number: 11118894
    Abstract: In some embodiments, systems, methods, and media for multiple reference arm spectral domain optical coherence tomography are provided which, in some embodiments, includes: a sample arm coupled to a light source; a first reference arm having a first path length; a second reference arm having a longer second path length; a first optical coupler that combines light from the sample arm and the first reference arm; a second coupler that combines light from the sample arm and the second reference arm; and an optical switch comprising: a first input port coupled to the first optical coupler; a second input coupled to the second coupler via an optical waveguide that induces a delay at least equal to an acquisition time of an image sensor; and an output coupled to the image sensor.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: September 14, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Guillermo J. Tearney, Yogesh Verma, David Odeke Otuya, Romain Luu
  • Patent number: 11117884
    Abstract: Provided herein are compounds and methods for treating a disorder associated with aberrant A? peptide levels, including Alzheimer's disease.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: September 14, 2021
    Assignees: The General Hospital Corporation, The Regents of the University of California
    Inventors: Steven L. Wagner, William C. Mobley, Rudolph E. Tanzi, Graham Johnson, Ronald Buckle, Nicholas Mayhew, Robert Jason Herr, Kevin D. Rynearson
  • Publication number: 20210278416
    Abstract: The present invention relates to a relationship between microbial metagenomic structure and function and clinical remission with anti-integrin therapy induction; longitudinal trajectory of changes in the microbiome with maintenance treatment; and a comprehensive predictive model incorporating clinical and microbiome-related data to accurately classify treatment response.
    Type: Application
    Filed: May 9, 2018
    Publication date: September 9, 2021
    Applicants: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: ASHWIN N. ANANTHAKRISHNAN, CHENGWEI LUO, VIJAY YAJNIK, RAMNIK J. XAVIER
  • Publication number: 20210277120
    Abstract: The technology described herein relates to vectors, isolated T cells, and methods of making and using the same, for example, in immunotherapeutic methods for T cell malignancies. In various examples, the T cells include a chimeric antigen receptor (CAR) that specifically binds to TRBC1 or TRBC2 and are modified so as to decrease or eliminate 003?, TRAC, and/or TRBC expression.
    Type: Application
    Filed: July 17, 2019
    Publication date: September 9, 2021
    Applicant: The General Hospital Corporation
    Inventor: Marcela V. Maus
  • Patent number: 11110097
    Abstract: The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with Tau or alpha-synuclein; or regulates amyloid peptide washout.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: September 7, 2021
    Assignee: The General Hospital Corporation
    Inventor: David R. Elmaleh
  • Patent number: 11109819
    Abstract: A system, and method, for quantitatively mapping of mitochondrial membrane potential of a tissue in a subject is provided. In some aspects, the provided method includes administering to the subject a detectably effective amount of a tracer as an emission tomography imaging agent; acquiring, using an emission tomography system, emission tomography data associated with the tissue; analyzing the emission tomography data to determine a concentration distribution of the tracer within the tissue; correlating the concentration distribution of the tracer with the membrane potential of the tissue; determining, using the correlating step, a membrane potential distribution of the tissue; and generating a report indicating the membrane potential distribution of the tissue.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: September 7, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Nathaniel M. Alpert, Georges El Fakhri, Nicola Guehl, Marc Normandin
  • Patent number: 11112232
    Abstract: Exemplary apparatus and method are provided for illuminating a sample. With such exemplary apparatus and/or method, it is possible to, using at least one source arrangement, provide at least one first electro-magnetic radiation. Using an optical system of an optics arrangement, it is possible to receive the first electro-magnetic radiation(s), and modifying the at least one first electro-magnetic radiation to be at least one second electro-magnetic radiation so as to be forwarded to the sample. Further, with the optical system, it is possible to extend the at least one second electro-magnetic radiation into or across the sample for a distance of at least 2 times the Raleigh range of a Gaussian beam when the optics arrangement and the sample are stationary with respect to one another. Additionally, using the optical system, it is possible to control a placement of a focus of the at least one second electro-magnetic radiation on or in the sample.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: September 7, 2021
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Biwei Yin, Kengyeh K. Chu, Barry Vuong
  • Patent number: 11111284
    Abstract: The invention features homo-multimers, e.g., homo-trimers, of TNFSF or TNF-like ligand muteins in which each TNFSF ligand or TNF-like ligand mutein monomer contains at least one cysteine residue substitution or insertion that promotes the formation of a disulfide bond with a cysteine residue on a neighboring TNFSF or TNF-like ligand mutein monomer. The invention features methods of producing such TNFSF and TNF-like ligand muteins, pharmaceutical compositions containing such muteins, and methods of using such muteins in cancer immunotherapy, in treating autoimmune and neurological diseases, and in reducing or eliminating the complications and risks of rejection in organ transplantation or tissue or organ repair or regeneration.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: September 7, 2021
    Assignee: The General Hospital Corporation
    Inventors: Denise L. Faustman, Eva Vanamee
  • Publication number: 20210268027
    Abstract: The invention provides bispecific chimeric antigen receptors (CARs) targeting CD37 and CD19, as well as related molecules, immune cells including the same, compositions thereof, and their methods of use. The invention further provides methods for treating a disease or disorder, e.g., a cancer.
    Type: Application
    Filed: June 21, 2019
    Publication date: September 2, 2021
    Applicant: The General Hospital Corporation
    Inventor: Marcela V. Maus
  • Publication number: 20210269547
    Abstract: The present disclosure provides antibody tumor-targeting assembly complexes (ATTACs) for selectively activating desired immune cells in the tumor microenvironment.
    Type: Application
    Filed: July 2, 2019
    Publication date: September 2, 2021
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Mark COBBOLD, David MILLAR
  • Patent number: 11104937
    Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 31, 2021
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Omar Abudayyeh, James Joseph Collins, Jonathan Gootenberg, Feng Zhang, Eric S. Lander, Roby Bhattacharyya, Deborah Hung
  • Patent number: 11103387
    Abstract: The present disclosure is directed to systems and methods that removing exogenous particles from a target region of the skin of a patient. The systems and methods can employ dermal lavage to remove the exogenous particles from the target region. In some instances, the exogenous particles can be residual tattoo ink after a tattoo removal process. A conduit can be sized and dimensioned for insertion into or around the target region to inject an irrigation fluid that defines an irrigation area. The exogenous particles can be suspended in the irrigation fluid. A device can be configured to form one or more channels in the irrigation area so that the exogenous particles are removable from the irrigation area.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: August 31, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Lilit Garibyan, Richard Rox Anderson, William Farinelli, Fernanda H. Sakamoto, Martin Purschke
  • Publication number: 20210262004
    Abstract: Disclosed herein are methods, assays, compositions and kits for the detection and measurement of UDP-glucose in biological samples. The methods, assays, compositions and kits are suitable for use with equipment that is readily available in a clinical laboratory, and permit rapid and reproducible detection and measurement of UDP-glucose at physiologically relevant levels in biological samples.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 26, 2021
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Sylvie Breton, Rachel Liberman, Leileata M. Russo