Patents Assigned to The General Hospital Corporation
  • Publication number: 20220299511
    Abstract: Provided herein, in some embodiments, are methods for analyzing immune cells in a blood sample from a subject having, suspected of having, or being at risk for bacterial sepsis. The present disclosure is based, at least in part, on the finding that certain immune cells are expanded in subjects having sepsis compared to healthy subjects.
    Type: Application
    Filed: June 17, 2020
    Publication date: September 22, 2022
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Miguel Reyes, Nir Hacohen, Paul C. Blainey, Michael R. Filbin, Marcia B. Goldberg, Roby P. Bhattacharyya
  • Publication number: 20220296594
    Abstract: The present disclosure provides compositions (e.g., pyrimidines) and methods capable of potentiating the effects of antimicrobial agents and/or antiviral agents against bacterial infections and/or viral infections, respectively. Methods of sensitizing bacteria to antimicrobial agents and/or antiviral agents, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at microbial infections and/or viral infections are also provided.
    Type: Application
    Filed: May 7, 2020
    Publication date: September 22, 2022
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE GENERAL HOSPITAL CORPORATION
    Inventors: Jason H. Yang, James J. Collins, Miguel A. Alcantar, Roby Bhattacharyya
  • Patent number: 11449989
    Abstract: Super-resolution images are generated from standard-resolution images acquired with a magnetic resonance imaging (“MRI”) system. More particularly, super-resolution (e.g., sub-millimeter isotropic resolution) images are generated from standard-resolution images (e.g., images with 1 mm or coarser isotropic resolution) using a deep learning algorithm, from which accurate cortical surface reconstructions can be generated.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: September 20, 2022
    Assignee: The General Hospital Corporation
    Inventors: Qiyuan Tian, Susie Yi Huang, Berkin Bilgic, Jonathan R. Polimeni
  • Patent number: 11446664
    Abstract: Extracting and concentrating particles from a first fluid sample includes: providing the first fluid sample to a fluid exchange module of a microfluidic device, providing a second fluid sample to the fluid exchange module, in which the first fluid sample and the second fluid sample are provided under conditions such that particle-free portions of the first fluid sample are shifted, and an inertial lift force causes the particles in the first fluid sample to cross streamlines and transfer into the second fluid sample; passing the second fluid sample containing the transferred particles to a particle concentration module under conditions such that particle-free portions of the second fluid sample are shifted, and such that the particles within the second fluid sample are focused to a streamline within the particle concentration module.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: September 20, 2022
    Assignee: The General Hospital Corporation
    Inventors: Ravi Kapur, Kyle C. Smith, Mehmet Toner
  • Patent number: 11441196
    Abstract: The present disclosure relates to method of distinguishing between two or more species of one or more organisms in a sample, by contacting a biological sample comprising ribosomal ribonucleic acid (rRNA) with a set of antisense probes, wherein the set of probes contains at least one detectable probe that is specific for a target rRNA sequence of each species to be tested, and wherein the individual probes specific for each species comprises less than about 85% sequence identity; and, detecting hybridization between one or more of the probes and the rRNA, thereby distinguishing between two or more species in a sample.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 13, 2022
    Assignees: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: Roby Bhattacharyya, Deborah Hung, Jonathan Livny
  • Publication number: 20220282325
    Abstract: The present invention features compositions and methods for assaying DNA methylation.
    Type: Application
    Filed: May 12, 2022
    Publication date: September 8, 2022
    Applicants: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Bradley BERNSTEIN, Sarah SHAREEF, Volker HOVESTADT
  • Patent number: 11433068
    Abstract: This disclosure provides compositions and methods of treating cancer by inhibiting histone methyltransferases alone or in combination by synergistically inhibiting a histone demethylase, or a histone deacetylase (HDAC), or a bromodomain (BRD)-containing protein, or a B-Raf kinase. In particular, the cancers have deficient of SWI/SNF chromatin remodeling complexes because of mutations in one or more of the complex's subunit members.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: September 6, 2022
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: David E. Fisher, Qing Yu Weng, Shinichiro Kato
  • Patent number: 11435368
    Abstract: Provided are a biomarker for diagnosing of the level of senescence, a composition and kit for diagnosing of the level of senescence to detect the biomarker, and a method of diagnosing the same. According to the composition and kit for the diagnosis of the level of senescence and the method of diagnosing senescence, the level of senescence of a subject is easily diagnosed, the health conditions of the subject are monitored, and a senescence-associated disease is prevented or diagnosed.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: September 6, 2022
    Assignees: CHA University Industry-Academic Cooperation Foundation, The General Hospital Corporation
    Inventors: Ji Sook Moon, Hak Ho Lee, Ala Jo, Jae Hyun Park, Ji Min Park, Chul Woo Lim, Yu Ri Choi
  • Patent number: 11434203
    Abstract: The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: September 6, 2022
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Huan Steven Liang
  • Patent number: 11433136
    Abstract: Provided herein are polymers, pH-sensitive polymers and/or linkers; conjugates comprising said polymers and/or linkers, optionally, coupled to one or more agents and/or targeting moieties; and particles (e.g., nanoparticles comprising the aforesaid polymers, linkers and/or conjugates), which can be used to enhance the delivery and/or efficacy of one or more agents in a subject.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: September 6, 2022
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology, XTUIT Pharmaceuticals, Inc.
    Inventors: Peter Blume-Jensen, Donald E. Chickering, III, Paul W. Kopesky, Lawrence A. Reiter, Alan Crane, Robert S. Langer, Rong Tong, Rakesh K. Jain, Vikash Pal Singh Chauhan, Joao Incio, Dai Fukumura
  • Patent number: 11436732
    Abstract: Lesions associated with acute ischemic stroke are automatically segmented in images acquired with computed tomography (“CT”) using a trained machine learning algorithm (e.g., a neural network). The machine learning algorithm is trained on labeled data and associated CT data (e.g., non-contrast CT data and CT angiography source image (“CTA-SI”) data). The labeled data can include segmented data indicating lesions, which are generated by segmenting diffusion-weighted magnetic resonance images acquired within a specified time window from when the associated CT data were acquired. CT data (e.g., non-contrast CT data and CTA-SI data) acquired from a subject are then acquired and input to the trained machine learning algorithm to generate output as segmented CT data, which indicate lesions in the subject.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: September 6, 2022
    Assignee: The General Hospital Corporation
    Inventors: Ona Wu, Ramon Gilberto Gonzalez
  • Publication number: 20220273569
    Abstract: The present disclosure relates to compositions and methods for manufacturing biomaterials that form flowable and injectable cold slurries. More particularly, the present disclosure relates to a composition containing a plurality of liposomes where the encapsulated internal liposomal media and external liposomal media have different freezing points.
    Type: Application
    Filed: July 23, 2020
    Publication date: September 1, 2022
    Applicants: The General Hospital Corporation, Brixton Biosciences, Inc.
    Inventors: Richard Rox Anderson, William Farinelli, Lilit Garibyan, Sameer Sabir, Charles Sidoti, Mansoor M. Amiji, Maie Taha
  • Patent number: 11427543
    Abstract: This invention relates to antagonists of G3BP2, G3BP1, and ZEB1. Pharmaceutical compositions comprising G3BP2 inhibitors, methods of inhibiting G3BP2, G3BP1, and ZEB1, methods of treating cancer and inflammation, and methods of identifying an inhibitor of cancer stems cells are also provided.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: August 30, 2022
    Assignee: The General Hospital Corporation
    Inventors: Igor Garkavtsev, Rakesh K. Jain
  • Patent number: 11427797
    Abstract: Presented is an airway organ bioreactor apparatus, and methods of use thereof, as well as bioartificial airway organs produced using the methods, and methods of treating subjects using the bioartificial airway organs. The bioreactor comprises: an organ chamber; an ingres line connecting the organ chamber and a reservoir system and comprising an arterial line, a venous line and a tracheal line; an egress line connecting the chamber and the reservoir system, pumps in ingress and egress lines; a controller to control fluid exchange; a chamber pressure sensor connected to the organ chamber.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: August 30, 2022
    Assignee: The General Hospital Corporation
    Inventor: Harald C. Ott
  • Patent number: 11428768
    Abstract: Methods and systems for producing a magnetic resonance (MR) image of a subject include acquiring a first physiological monitoring signal related to a first physiological process of the subject and acquiring a second physiological monitoring signal related to a second physiological process of the subject. The method also includes analyzing the first physiological monitoring signal and the second physiological monitoring signal to identify at least a first trigger point and a second trigger point and, upon identifying the first trigger point, applying a radiofrequency (RF) saturation module at a selected frequency to saturate a selected spin species in the subject. Upon identifying the second trigger point, the method includes performing a chemical exchange striation transfer (CEST) readout to acquire CEST data and then reconstructing the CEST data to produce a CEST image of the subject.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: August 30, 2022
    Assignee: The General Hospital Corporation
    Inventor: Phillip Zhe Sun
  • Publication number: 20220265791
    Abstract: Provided are compositions that include one or more synthetic target peptides, wherein each synthetic target peptide is about or at least 8-50 amino acids long; and has an amino acid sequence as set forth in Table 2 and/or Table 3. Also provided are in vitro populations of dendritic cells that include the disclosed compositions, in vitro population of CD8+ T cells capable of being activated upon being brought into contact with the disclosed populations of dendritic cells, antibodies or antibody-like molecules that specifically binds to a complex of an MHC class I molecule and a peptide having an amino acid sequence as set forth in Table 2 and/or Table 3, methods for treating and/or preventing cancers by administering a therapeutically effective dose of a composition that includes at least one target peptide having an amino acid sequence as set forth in Table 2 and/or Table 3.
    Type: Application
    Filed: July 21, 2020
    Publication date: August 25, 2022
    Applicants: University of Virginia Patent Foundation, The University of Birmingham, The General Hospital Corporation
    Inventors: Donald F. Hunt, Jeffrey Shabanowitz, Keira Mahoney, Jennifer G. Abelin, Mohammad Ovais Azizzanjani, Paisley Trantham Myers, Stacy Alyse Malaker, Andrew Norris, Jennifer Hitchcock, Xi Peng, Negin Ghafourian, Mark Cobbold, Sarah Penny, Nico Buettner, James M. Heather
  • Patent number: 11421233
    Abstract: Described herein are methods and assays relating to the presence and/or level of circulating tumor cells (CTCs). These CTC-Cs represent a highly metastatic subpopulation of CTCs. In some embodiments, the methods and assays described herein relate to the treatment of cancer.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: August 23, 2022
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Nicola Aceto, Daniel Arie Haber, Shyamala Maheswaran
  • Patent number: 11419588
    Abstract: Exemplary embodiments of an apparatus can be provided for obtaining portions or samples of tissue from a target region of a biological tissue. One or more needles can be provided that have a small internal diameter, e.g., about 1 mm or less, and the needles can be configured to extract the tissue portions when the needles are inserted into and withdrawn from the tissue. Windows and/or markings can be provided on the wall of the needles to facilitate access to the sample. The needles can be provided in an enclosure, and an actuator can be provided to direct the needles into the tissue and/or withdraw them. A plurality of tissue portions having known relative locations in the target region can be obtained, and extraction of the tissue portions can be well-tolerated by the tissue as compared with conventional punch biopsies or the like.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: August 23, 2022
    Assignee: The General Hospital Corporation
    Inventors: William G. Austen, Dieter Manstein
  • Patent number: 11419894
    Abstract: This invention is directed to the treatment of cancers, e.g., inflammatory breast cancer, with NK (natural killer) cells wherein the cells are modified ex vivo such that their ability to overcome the chemorepellant effect of a tumor is enhanced. The cells may be genetically modified ex vivo and/or modified by contacting the cells ex vivo with an anti-chemorepellant agent. This invention also provides ex vivo modified NK cells, which are modified such that they express no or substantially no CXCR4 on their cell surface, or express CXCR7, or express a chimeric antigen receptor, or combinations thereof. The invention also relates to methods for treating a patient having a tumor, e.g., inflammatory breast cancer, by administering the modified NK cells, with or without treatment with other conventional anticancer treatments, e.g., chemotherapy, radiotherapy, viral therapies, hormonal therapies, as well as other immunotherapies and anti-chemorepellant therapies.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: August 23, 2022
    Assignee: The General Hospital Corporation
    Inventors: Mark C. Poznansky, Patrick Reeves
  • Publication number: 20220256839
    Abstract: One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.
    Type: Application
    Filed: May 4, 2022
    Publication date: August 18, 2022
    Applicant: The General Hospital Corporation
    Inventors: William G. Austen, JR., Michael C. McCormack, Robert W. Redmond, Irene E. Kochevar