Patents Assigned to The General Hospital Corporation
  • Patent number: 10292381
    Abstract: One aspect of the invention provides a vessel treatment system including: a housing defining at least one opening adapted and configured to receive an anatomical vessel; and a humidifier in communication with the housing, the humidifier adapted and configured to introduce humidity into the housing to prevent desiccation of the anatomical vessel. Another aspect of the invention provides a kit including: the vessel treatment system as described herein; and a passivation agent. Another aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; and placing the resected anatomical vessel in a humidified chamber while the tissue passivation agent cures.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: May 21, 2019
    Assignee: The General Hospital Corporation
    Inventors: William G. Austen, Jr., Michael C. McCormack, Robert C. Redmond, Irene E. Kocheavar
  • Patent number: 10293133
    Abstract: A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 21, 2019
    Assignee: The General Hospital Corporation
    Inventors: Warren M. Zapol, Binglan Yu, Paul Hardin, Matthew Hickcox
  • Publication number: 20190144862
    Abstract: Provided herein are methods and compositions for treatment and/or prevention of liver disease. Aspects of the present disclosure relate to the engineering of a quiescent Hepatic Stellate Cell, and use of the engineered quiescent Hepatic Stellate Cell, or population thereof in the treatment and/or prevention of liver disease.
    Type: Application
    Filed: May 19, 2017
    Publication date: May 16, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Michael Yoonsuk CHOI, Byeong-Moo KIM
  • Publication number: 20190144867
    Abstract: A method for inhibiting metastasis of cancer cells is provided. Inhibitors of heparan sulfate (HS) or hyaluronic acid (HA) are applied to a tumor or a surgical location after removal of the bulk of the tumor. The inhibitors enzymatically cleave surface HS or HA; genetically modify cancer cells to decrease HS or HA production or interfere with the signaling pathway between HS or HA and a MMP or syndecan.
    Type: Application
    Filed: September 19, 2016
    Publication date: May 16, 2019
    Applicants: Research Foundation of the City University of New York, Memorial Sloan Kettering Cancer Center, The General Hospital Corporation D/B/A Massachusetts General Hospital
    Inventors: John M. TARBELL, Lance L. MUNN, Henry QAZI, Zhongdong SHI
  • Publication number: 20190144942
    Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions in immune cells. The present invention provides tools and methods for modulating immune cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
    Type: Application
    Filed: February 22, 2017
    Publication date: May 16, 2019
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE GENERAL HOSPITAL CORPORATION
    Inventors: Alexander K. SHALEK, Kellie E. KOLB, Michael B. COLE, Nir YOSEF, Enrique Martin GAYO, Zhengyu OUYANG, Xu YU
  • Patent number: 10287580
    Abstract: Disclosed are memory-regulating agents and methods that target actin binding LIM protein family, member 3 (ABLIM3). Specifically, the disclosure provides methods of inhibiting Ablim3 using inhibitory nucleic acids that target the Ablim3 gene or mRNA to improve memory in subjects with memory dysfunction associated with Alzheimer's Disease (AD), normal aging, or posttraumatic stress disorder (PTSD). Further disclosed is a cell-based assay that can be used to screen for small molecule regulators of Ablim3 function.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: May 14, 2019
    Assignee: The General Hospital Corporation
    Inventors: Amar Sahay, Nannan Guo
  • Patent number: 10288868
    Abstract: Exemplary apparatus, systems, methods of making, and methods of using a configuration in an optical arrangement for forward viewing spectrally encoded endoscopy (SEE) probe can be provided. For example, the probe can comprise a light focusing component, a light guiding component, a light reflecting component, and a grating component.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: May 14, 2019
    Assignees: CANON U.S.A., INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: Guillermo J. Tearney, Dongkyun Kang, Mitsuhiro Ikuta, Kenji Yamazoe, Anderson Thi Mach, Jacob Schieffelin Brauer
  • Patent number: 10288610
    Abstract: Provided are assays, kits and compositions for testing subjects, particularly asymptomatic subjects, to ascertain whether or not they are carriers of Salmonella enterica serotype Typhi. Methods for detecting the presence of Salmonella enterica serotype Typhi indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: May 14, 2019
    Assignees: THE GENERAL HOSPITAL CORPORATION, INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH (ICDDR,B), THE CHANGELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
    Inventors: Richelle Charles, Edward T. Ryan, Firdausi Qadri, Stephen Baker
  • Patent number: 10285568
    Abstract: In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: May 14, 2019
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Brett Eugene Bouma, Michalina Gora, Melissa Suter, Hongki Yoo, Milen Shishkov
  • Publication number: 20190135902
    Abstract: Provided herein are self-assembling pharmaceutical compositions comprising a heat shock protein fused to a biotin-binding protein, wherein the biotin-binding protein is non-covalently bound to four biotinylated components, and further wherein at least two of the four biotinylated components are not identical.
    Type: Application
    Filed: December 5, 2016
    Publication date: May 9, 2019
    Applicant: The General Hospital Corporation
    Inventors: Jeffrey A. Gelfand, Mark C. Poznansky, Pierre R. Leblanc, Svetlana E. Korochkina
  • Publication number: 20190136306
    Abstract: The technology described herein is directed to methods of determining oligonucleotide sequences, e.g. by enriching target sequences prior to sequencing the sequences.
    Type: Application
    Filed: May 21, 2018
    Publication date: May 9, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Anthony John Iafrate, Long Phi Le, Zongli Zheng
  • Publication number: 20190137491
    Abstract: Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with P. copri or a portion thereof. In one aspect of the invention the immunological reactivity of the subject to one or more protein of P. copri or polypeptide fragments thereof such as protein Pc-p27 or polypeptide fragments thereof, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.
    Type: Application
    Filed: June 6, 2017
    Publication date: May 9, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Allen C. Steere, Elise E. Drouin
  • Publication number: 20190134273
    Abstract: The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 9, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Ebru ORAL, Orhun K. MURATOGLU
  • Patent number: 10279139
    Abstract: In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: May 7, 2019
    Assignee: The General Hospital Corporation
    Inventors: Warren M. Zapol, Binglan Yu, Paul Hardin, Matthew Hickcox
  • Patent number: 10280152
    Abstract: Provided herein are radiolabelled compounds useful for imaging GSK-3 kinase. An exemplary radiolabelled compound provided herein is useful as a radiotracer for imaging GSK-3 kinase using PET imaging. Methods for preparing the radiolabelled compounds and diagnostic methods using the radiolabelled compounds are also provided.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 7, 2019
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Huan Steven Liang
  • Patent number: 10278677
    Abstract: Exemplary embodiments of an apparatus can be provided for obtaining portions or samples of tissue from a target region of a biological tissue. One or more needles can be provided that have a small internal diameter, e.g., about 1 mm or less, and the needles can be configured to extract the tissue portions when the needles are inserted into and withdrawn from the tissue. Windows and/or markings can be provided on the wall of the needles to facilitate access to the sample. The needles can be provided in an enclosure, and an actuator can be provided to direct the needles into the tissue and/or withdraw them. A plurality of tissue portions having known relative locations in the target region can be obtained, and extraction of the tissue portions can be well-tolerated by the tissue as compared with conventional punch biopsies or the like.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: May 7, 2019
    Assignee: The General Hospital Corporation
    Inventors: William G. Austen, Dieter Manstein
  • Patent number: 10278724
    Abstract: Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 7, 2019
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Falguni Asrani, William Farinelli, Ajay Shah, Vincent Liu, Richard R. Anderson
  • Patent number: 10278990
    Abstract: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 7, 2019
    Assignees: Children's Medical Center Corporation, The General Hospital Corporation
    Inventors: Leonard I. Zon, Trista E. North, Wolfram Goessling
  • Patent number: 10280225
    Abstract: Disclosed herein are non-myeloablative antibody-toxin conjugates and compositions that target cell surface markers, such as the CD34, CD45 or CD117 receptors, and related methods of their use to effectively conditioning a subject's tissues (e.g., bone marrow tissue) prior to engraftment or transplant. The compositions and methods disclosed herein may be used to condition a subject's tissues in advance of, for example, hematopoietic stem cell transplant and advantageously such compositions and methods do not cause the toxicities that are commonly associated with traditional conditioning methods.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: May 7, 2019
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation, Children's Medical Center Corporation
    Inventors: David T. Scadden, Rahul Palchaudhuri, Derrick J. Rossi, Agnieszka D. Czechowicz
  • Publication number: 20190128982
    Abstract: Described here are systems and methods for performing magnetic resonance imaging (“MRI”) using radio frequency (“RF”) phase gradients to provide spatial encoding of magnetic resonance signals rather than the conventional magnetic field gradients. Particularly, the systems and methods described here implement swept RF pulses (e.g., wideband, uniform rate, and smooth transition (“WURST”) RF pulses) and a quadratic phase correction to enable RF phase gradient encoding in inhomogeneous background (B0) magnetic fields.
    Type: Application
    Filed: April 11, 2017
    Publication date: May 2, 2019
    Applicant: The General Hospital Corporation
    Inventors: Lawrence L. WALD, Clarissa Z. COOLEY, Jason STOCKMANN, Bastien GUERIN, Matthew ROSEN