Patents Assigned to The General Hospital Corporation
  • Patent number: 10780294
    Abstract: A problem of incomplete inhibition of harmful cells/bacteria and short duration of time, after the photodynamic treatment, during which such cells may re-grow, is solved by exposing the target bacteria with a multi-component photosensitizer material formed by adding a predetermined potentiating chemical to a conventional single-component photosensitizer at the target, prior to irradiating the target with light. The multi-component photosensitizer is effectuated by forming a mix of the two chemical compositions or by sequential exposure of the bacteria to a single-component photosensitizer and the potentiating chemical of choice.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: September 22, 2020
    Assignee: The General Hospital Corporation
    Inventors: Daniela Vecchio, Michael R. Hamblin, Yingying Huang, Liyi Huang, Giacomo Landi, Jeffrey Gelfand, Timothy Brauns
  • Patent number: 10781178
    Abstract: The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: September 22, 2020
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Huan Steven Liang
  • Publication number: 20200289696
    Abstract: A device for selectively providing an odor-rich environment includes a housing and a cover. The housing includes a central cavity and a plurality of chambers configured to store a predefined fragrance therein and having a respective outlet formed on an outer wall of the housing. The cover includes an exterior surface having at least one vent formed on the exterior surface. The exterior surface includes an interior sidewall and an exterior sidewall forming an inner chamber that slidably engages the housing such that the cover is configured to move between an open position and a closed position. Responsive to the cover being in the open position, the at least one vent is generally adjacent to the outlet of at least one of the plurality of chambers of the housing. The odor-rich environment can assist in preventing and/or treating postoperative delirium (POD) postoperative cognitive dysfunction (POCD), and/or pain in a subject.
    Type: Application
    Filed: March 8, 2017
    Publication date: September 17, 2020
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventor: Zhongcong Xie
  • Patent number: 10773047
    Abstract: In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 15, 2020
    Assignee: The General Hospital Corporation
    Inventors: Warren M. Zapol, Binglan Yu, Paul Hardin, Matthew Hickcox
  • Patent number: 10775462
    Abstract: A system and method is provided that includes acquiring chemical exchange saturation transfer (CEST) data with the MRI system and generating an acquired Z-spectrum (Z) from the CEST data. The system and method also includes computing an estimated direct water saturation (Z?) based using at least one of relaxation measurements derived from the CEST data or imaging parameters used to acquire the CEST data with the MRI system, computing a direct saturation corrected Z-spectrum (?Z) using the acquired Z-spectrum (Z) and the estimated direct water saturation (Z?), and generating a CEST image of the subject using the direct saturation corrected Z-spectrum (?Z).
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: September 15, 2020
    Assignee: The General Hospital Corporation
    Inventors: Phillip Zhe Sun, Iris Yuwen Zhou
  • Patent number: 10765700
    Abstract: The invention features methods of producing compositions enriched in Tregs and methods for treating immunological disorders using these compositions. The invention also features methods for producing compositions enriched in lymphocytes and depleted of Tregs and the use of these compositions in the treatment of proliferative disorders.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: September 8, 2020
    Assignee: The General Hospital Corporation
    Inventor: Denise L. Faustman
  • Patent number: 10767168
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: September 8, 2020
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Patent number: 10758672
    Abstract: The subject technology is embodied in a method for predicting a delivery rate of a plurality of drugs dispensed by multiple infusion pumps at a delivery point. The method includes receiving one or more operating parameters related to multiple drug pumps and a carrier fluid pump, wherein each of the drug pumps dispenses a drug, and the carrier fluid pump dispenses a carrier fluid. The method also includes determining a delivery rate of a first drug at the delivery point. This can be done by predicting time variation of a concentration of the first drug at the delivery point based on a mathematical model of a mixed flow through a fluid path that terminates at the delivery point. The mixed flow includes the drugs and the carrier fluid. The model includes the operating parameters and a plurality of flow-parameters related to the mathematical model of the mixed flow.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: September 1, 2020
    Assignee: The General Hospital Corporation
    Inventors: Robert A. Peterfreund, Michael Parker, Mark A. Lovich, Nathaniel M. Sims
  • Patent number: 10760064
    Abstract: Methods and constructs for RNA-guided targeting of transcriptional activators to specific genomic loci.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 1, 2020
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Morgan Maeder
  • Patent number: 10758569
    Abstract: This invention relates to compounds of Formula I: (Formula I), and pharmaceutically acceptable salt thereof, which are allosteric effectors that increase the oxygen-being affinity of hemoglobin, which are useful in the treatment of sickle cell disease, high altitude tissue hypoxia, and other conditions.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: September 1, 2020
    Assignee: The General Hospital Corporation
    Inventors: Warren M. Zapol, Kenneth D. Bloch, Akito Nakagawa, Francine E. Lui, Revital Freedman
  • Patent number: 10758174
    Abstract: A system and method for diagnosing mental or emotional disorders is disclosed. An affective BCI component is incorporated into a closed loop, symptom—responsive psychiatric DBS system. A series of input data related to a brain of the patient is acquired while the patient performs a battery of behavioral tasks. From the patient's performance on the task battery, the system identifies what is abnormal for that individual patient in terms of functional domains. Patient-specific behavioral measurements are then linked to patterns of activation and de-activation across different brain regions, identifying specific structures that are the source of the patient's individual impairment.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: September 1, 2020
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Alik S. Widge, Thilo Deckersbach, Darin Dougherty, Emad Eskandar, Kristen Ellard
  • Publication number: 20200270671
    Abstract: Aspects of the technology disclosed herein relate to methods for preparing and analyzing nucleic acids. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.
    Type: Application
    Filed: October 2, 2019
    Publication date: August 27, 2020
    Applicants: The General Hospital Corporation, ArcherDX, Inc.
    Inventors: Anthony John IAFRATE, Long Phi LE, Zongli ZHENG, Jason MYERS, Joshua STAHL
  • Patent number: 10750739
    Abstract: Methods for stabilizing blood samples, e.g., clinical blood samples, for storage or transportation before use. Exemplary applications include but are not limited to enrichment of leukocyte subtypes such as T-cells or neutrophils for cytokine and immuno-assays; isolation of progenitor cells from cord blood or peripheral blood for transplantation; isolation of fetal cells from the maternal blood for diagnosis; and sorting of circulating tumor cells for cancer detection and therapy.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: August 25, 2020
    Assignee: The General Hospital Corporation
    Inventors: Rebecca Sandlin, Keith Wong, Shannon Tessier, Mehmet Toner, Shannon Stott
  • Publication number: 20200253981
    Abstract: The present disclosure provides methods of increasing skin pigmentation in a subject in need thereof using salt-inducible kinase (SIK) inhibitors, such as macrocyclic compounds of Formula (I), bicyclic urea compounds of Formula (II), (III), and (IV), and compounds of Formula (V), (VI), (VI-A), or (VII). Also provided are pharmaceutical compositions, methods, and uses that include or involve a compound described herein.
    Type: Application
    Filed: February 28, 2018
    Publication date: August 13, 2020
    Applicants: The General Hospital Corporation, Dana-Farber Cancer Institute, Inc.
    Inventors: David E. Fisher, Nisma Mujahid, Ryo Murakami, Nathanael S. Gray, Yanke Liang, Hwan Geun Choi
  • Patent number: 10736494
    Abstract: According to exemplary embodiments of the present disclosure, apparatus, device and method can be provided which can provide imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques in an automatic or semiautomatic manner. The exemplary apparatus, device and method can utilize a tethered capsule catheter with a mechanism for manual, semi-automatic or automatic traversing in the luminal organ with a controlled velocity and/or image quality. The exemplary apparatus can include feedback information about tension applied to the catheter during its movement that can be used to adjust velocity and assure patient comfort and safety for example during passing through natural sphincters and/or narrowing of the luminal organs and preventing from breaking of the catheter. The exemplary apparatus can also adjust velocity in order to provide good quality of acquired images, for example to engaged peristalsis and provide contact with the tissue.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: August 11, 2020
    Assignee: The General Hospital Corporation
    Inventors: Michalina Gora, Guillermo J. Tearney, Robert Carruth
  • Patent number: 10736654
    Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: August 11, 2020
    Assignee: The General Hospital Corporation
    Inventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
  • Patent number: 10738121
    Abstract: This disclosure relates to therapeutic use of integrin-binding antibodies.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: August 11, 2020
    Assignee: The General Hospital Corporation
    Inventor: M. Amin Arnaout
  • Patent number: 10736731
    Abstract: A method for treating hyperopia or presbyopia in a patient, the method comprising making a cut deep in the patient's cornea to create a two-dimensional slit adjacent to and generally parallel to an anterior surface of the cornea and injecting a liquid or semi-solid transparent filler material into the deep cut in an amount sufficient to flatten the posterior surface of the cornea to increase the refractive power of the cornea by a predetermined correction of up to about 5 diopters due to the physical flattening of the posterior surface of the cornea, wherein the transparent filler material comprises a refractive index of about 1.3 to about 1.6, and forms a corneal implant with a lenticular shape within the cornea.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: August 11, 2020
    Assignee: The General Hospital Corporation
    Inventors: Richard Rox Anderson, Reginald Birngruber
  • Patent number: 10739250
    Abstract: Reusable network of spatially-multiplexed microfliuidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: August 11, 2020
    Assignee: The General Hospital Corporation
    Inventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
  • Patent number: 10738303
    Abstract: Sensitive, unbiased methods for genome-wide detection of potential CRISPR-Cas9 off-target cleavage sites from cell type-specific genomic DNA samples.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 11, 2020
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Shengdar Tsai