Patents Assigned to The General Hospital Corporation dba Massachusetts General Hospital
  • Patent number: 10238440
    Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: March 26, 2019
    Assignees: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL
    Inventors: Stanley E Asnis, Peter D Asnis
  • Publication number: 20170100433
    Abstract: This invention provides ex vivo methods for making modified natural killer cell compositions having overall anti-fugetactic properties for the effective and efficient treatment of tumors or cancers in a patient, and compositions and use thereof.
    Type: Application
    Filed: September 16, 2016
    Publication date: April 13, 2017
    Applicant: THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL
    Inventors: Mark C. POZNANSKY, Fabrizio VIANELLO
  • Publication number: 20160193312
    Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.
    Type: Application
    Filed: November 9, 2015
    Publication date: July 7, 2016
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: MARK C. POZNANSKY, JOHN T. POTTS, JR., FABRIZIO VIANELLO, NATALIA PAPETA
  • Publication number: 20160193311
    Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.
    Type: Application
    Filed: November 9, 2015
    Publication date: July 7, 2016
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: MARK C. POZNANSKY, JOHN T. POTTS, JR., FABRIZIO VIANELLO, NATALIA PAPETA
  • Publication number: 20160184257
    Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.
    Type: Application
    Filed: November 9, 2015
    Publication date: June 30, 2016
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: MARK C. POZNANSKY, JOHN T. POTTS, JR., FABRIZIO VIANELLO, NATALIA PAPETA
  • Publication number: 20160166538
    Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.
    Type: Application
    Filed: November 9, 2015
    Publication date: June 16, 2016
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: MARK C. POZNANSKY, JOHN T. POTTS, JR., FABRIZIO VIANELLO, NATALIA PAPETA
  • Publication number: 20160166537
    Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides antifugetactic agents and methods for the use thereof in enhancing an immune response.
    Type: Application
    Filed: November 9, 2015
    Publication date: June 16, 2016
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: MARK C. POZNANSKY, JOHN T. POTTS, Jr., FABRIZIO VIANELLO, NATALIA PAPETA
  • Publication number: 20160128976
    Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.
    Type: Application
    Filed: November 9, 2015
    Publication date: May 12, 2016
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: MARK C. POZNANSKY, JOHN T. POTTS, Jr., FABRIZIO VIANELLO, NATALIA PAPETA
  • Publication number: 20160128975
    Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.
    Type: Application
    Filed: November 9, 2015
    Publication date: May 12, 2016
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Mark C. POZNANSKY, John T. POTTS, JR., Fabrizio VIANELLO, Natalia PAPETA
  • Publication number: 20140194937
    Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.
    Type: Application
    Filed: January 2, 2014
    Publication date: July 10, 2014
    Applicants: The General Hospital Corporation dba Massachusetts General Hospital, THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Stanley E. Asnis, Peter D. Asnis
  • Publication number: 20120215321
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: April 23, 2012
    Publication date: August 23, 2012
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Publication number: 20100082101
    Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Application
    Filed: August 18, 2006
    Publication date: April 1, 2010
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • Publication number: 20090210066
    Abstract: There is disclosed a total knee replacement prosthesis, which can substitute the function of an anterior and/or a posterior cruciate ligament. A femoral component containing two intercondylar surfaces and an intercondylar region, a tibial component having a tibial platform and a bearing component, and a protrusion from the bearing component also are disclosed.
    Type: Application
    Filed: January 21, 2005
    Publication date: August 20, 2009
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventor: Murali Jasty
  • Publication number: 20080262120
    Abstract: The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided.
    Type: Application
    Filed: April 29, 2008
    Publication date: October 23, 2008
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventor: Orhun K. MURATOGLU
  • Publication number: 20080215142
    Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
    Type: Application
    Filed: March 3, 2008
    Publication date: September 4, 2008
    Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Publication number: 20080214692
    Abstract: The present invention relates to methods for making oxidation resistant homogenized polymeric materials and medical implants that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing, cross-linked UHMWPE with vitamin E by diffusion and annealing the antioxidant doped UHMWPE in a super critical fluid, and materials used therein.
    Type: Application
    Filed: August 18, 2006
    Publication date: September 4, 2008
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • Publication number: 20080090934
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
    Type: Application
    Filed: November 30, 2007
    Publication date: April 17, 2008
    Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.
    Inventors: Orhun Muratoglu, Stephen Spiegelberg
  • Publication number: 20070275030
    Abstract: The invention relates to cross-link-resistant injectable hydrogel formulations and methods of partially or practically wholly inhibiting injectable hydrogel formulations from cross-linking, for example, during irradiation, using anti-cross-linking agents, which facilitates injectability of the hydrogel formulation. The invention also relates to methods of making the cross-link-resistant, for example, irradiation cross-link resistant, injectable hydrogel formulations, and methods of administering the same in treating a subject in need.
    Type: Application
    Filed: May 25, 2007
    Publication date: November 29, 2007
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Orhun K. MURATOGLU, Ebru Oral, Hatice Bodugoz-Senturk
  • Publication number: 20070267030
    Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Application
    Filed: April 24, 2007
    Publication date: November 22, 2007
    Applicant: The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Orhun MURATOGLU, Ebru Oral
  • Publication number: 20070114702
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: November 29, 2006
    Publication date: May 24, 2007
    Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.
    Inventors: Orhun MURATOGLU, Stephen Spiegelberg