Patents Assigned to The General Hospital Corporation
  • Methods and systems for non-contact construction of an internal structure
    Patent number: 11801374
    Abstract: The present disclosure includes system, methods, and kits relating to creating a second structure with a plurality of first structures at a target site inside or adjacent to a host object. The methods include the step of generating a field that non-invasively penetrates into the host object. The methods further include the step of positioning a first portion of the plurality of first structures at the target site using a force corresponding to the field. Additionally, the methods include the step of linking the first portion of the plurality of first structures with one another and/or the host object at the target site to form the second structure.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: October 31, 2023
    Assignee: The General Hospital Corporation
    Inventors: Li Li, Guillermo J. Tearney
  • Cromolyn derivatives and related methods of imaging and treatment
    Patent number: 11801316
    Abstract: Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula: wherein: X is OH, C1-C6 alkoxyl; Y and Z are independently selected form a C1-C6 alkyl, C1-C6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H and X is OH.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: October 31, 2023
    Assignee: The General Hospital Corporation
    Inventor: David R. Elmaleh
  • TR-FRET BASED ASSAY FOR DETECTION OF ANTIBODIES IN SEROLOGICAL SAMPLES
    Publication number: 20230341394
    Abstract: The present invention relates to a homogeneous, time resolved, Förster resonance energy transfer (TR-FRET)-based method for detection of SARS-CoV-2, SARS CoV-1, and MERS-CoV antibodies in a patient fluid sample.
    Type: Application
    Filed: August 16, 2021
    Publication date: October 26, 2023
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Eric Fischer, Radoslaw Nowak, Hong Yue, Daan Overwijn, Ralph Mazitschek, Neil Connor Payne
  • INJECTABLE SLURRIES AND METHODS OF MANUFACTURING THE SAME
    Publication number: 20230338276
    Abstract: A method for treating vascular diseases is provided. The method includes fabricating a sterile ice slurry including water and ice particles, cooling the sterile ice slurry to a predetermined temperature, and injecting the sterile ice slurry into a desired tissue region. The desired tissue region includes perivascular adipose tissue.
    Type: Application
    Filed: October 14, 2022
    Publication date: October 26, 2023
    Applicant: The General Hospital Corporation
    Inventors: Lilit Garibyan, William A. Farinelli, Richard Rox Anderson, Emilia Javorsky
  • SYSTEMS, METHODS, AND MEDIA FOR MULTIPLE BEAM OPTICAL COHERENCE TOMOGRAPHY
    Publication number: 20230341222
    Abstract: Systems, methods, and media for multiple beam optical coherence tomography are provided which, in some embodiments, include: a light source; a splitter that outputs a fraction of light to various waveguides; optical components that receive light from the waveguides and direct the light as beams that simultaneously impinge a sample at different lateral positions, and collect backscattered light from the lateral positons; another splitter that outputs a fraction of light to waveguides of a reference arm as reference light samples; a mixer that receives the backscattered light samples and the reference light samples, and combines each backscattered sample with a corresponding reference sample such that the mixer outputs fringes; and a detector that receives the fringes, and outputs OCT signals, each indicative of a structure of the sample at a respective lateral position.
    Type: Application
    Filed: December 21, 2020
    Publication date: October 26, 2023
    Applicant: The General Hospital Corporation
    Inventors: Benjamin Vakoc, Yongjoo Kim
  • Devices, systems, and methods for advancing and positioning tethered capsule microendoscopes
    Patent number: 11793396
    Abstract: In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: October 24, 2023
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Chulho Daryl Hyun, Joseph A. Gardecki
  • Systems and methods for respiratory-gated nerve stimulation
    Patent number: 11794012
    Abstract: Systems and methods are provided for neurostimulation timed relative to respiratory activity. Neurostimulation may be delivered to the spinal cord, the vagus nerve, and/or branches of the vagus nerve to provide therapeutic outcomes by controlling or adjusting stimulation based on pulmonary activity. In particular, the systems and methods use a detecting device to detect respiratory activity over time. Specific points in the respiratory signal are identified where central autonomic nuclei may be more receptive to afferent input and a stimulator is instructed to provide neurostimulation to at least one auricular branch of a vagus nerve, or to a cervical branch of the vagus nerve, or to a spinal cord of the subject. In this regard, the neurostimulation is advantageously correlated to the detected respiratory activity providing improved therapeutic outcomes.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: October 24, 2023
    Assignee: The General Hospital Corporation
    Inventors: Vitaly Napadow, Jill M. Goldstein, Ronald G. Garcia, Benjamin Pless
  • Subject-specific and hardware-specific bias removal from functional magnetic resonance imaging signals using deep learning
    Patent number: 11796615
    Abstract: Anatomical, physiological, instrumental, and other related biases are removed from functional magnetic resonance imaging (“fMRI”) signal data using deep learning algorithms and/or models, such as a neural network. Bias characterization data are used as an auxiliary input to the neural network. The bias characterization data can be subject-specific bias characterization data (e.g., cortical thickness maps, cortical orientation angle maps, vasculature maps), hardware-specific bias characterization data (e.g., coil sensitivity maps, coil transmission profiles), or both. The subject-specific bias characterization data can be extracted from the fMRI signal data using a second neural network. The bias-reduced fMRI signal data can include time-series signals, functional activation maps, functional connectivity maps, or combinations thereof.
    Type: Grant
    Filed: April 18, 2022
    Date of Patent: October 24, 2023
    Assignee: The General Hospital Corporation
    Inventors: Olivia M. Viessmann, Jonathan R. Polimeni, Bruce Fischl
  • Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same
    Patent number: 11795491
    Abstract: The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: October 24, 2023
    Assignee: The General Hospital Corporation
    Inventors: Tayyaba Hasan, Ulysses W. Sallum, Sarika Verma, Gerard Nau
  • METHODS FOR CHARACTERIZING BIOLOGICAL SAMPLES
    Publication number: 20230332246
    Abstract: The disclosure features in some aspects methods for identifying subjects with constitutional mismatch repair deficiency (CMMRD), a mismatch repair deficiency (MMD) cancer, a polymerase proofreading deficiency (PPD) cancer, and/or a MMD&PPD cancer. The disclosure also features in some aspects methods for predicting response of a subject to immunotherapy.
    Type: Application
    Filed: May 5, 2023
    Publication date: October 19, 2023
    Applicants: The General Hospital Corporation, The Hospital for Sick Children
    Inventors: Gad GETZ, Yosef MARUVKA, Uri TABORI, Jiil CHUNG
  • Methods of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
    Patent number: 11788144
    Abstract: The invention relates to method for identifying and selecting a subject with increased risk of developing a cardiometabolic disease and optionally, providing a personalized medicine method, which may involve sequencing at least part of a genome of one or more cells in a blood sample of the subject and identifying from the sequencing one or more mutations in one or more somatic mutations.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: October 17, 2023
    Assignees: The Brigham and Women's Hospital, Inc., The General Hospital Corporation
    Inventors: Benjamin Levine Ebert, Siddhartha Jaiswal, Sekar Kathiresan
  • Compositions and methods for modulating MECP2 expression
    Patent number: 11788089
    Abstract: Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of MECP2. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of MECP2. Methods for modulating expression of MECP2 using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of MECP2.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: October 17, 2023
    Assignee: The General Hospital Corporation
    Inventors: Arthur M. Krieg, Romesh R. Subramanian, James McSwiggen, Jeannie T. Lee
  • Systems and methods for predicting arousal to consciousness during general anesthesia and sedation
    Patent number: 11786132
    Abstract: A system and method for monitoring a patient suspected of experiencing a state of unconsciousness are provided. In certain aspects, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of electroencephalogram signals, and determining, from the plurality of electroencephalogram signals, at least one of frequency information and amplitude information. The method can also include identifying, using the at least one of the frequency information and the amplitude information, spatiotemporal signatures indicative of a likelihood of arousing the patient to consciousness by applying an external stimulus and generating a report indicating the likelihood of arousing the patient to consciousness by applying the external stimulus.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: October 17, 2023
    Assignee: The General Hospital Corporation
    Inventors: Patrick L. Purdon, Oluwaseun Akeju, Emery N. Brown
  • 4,5-annulated 1,2,4-triazolones
    Patent number: 11787797
    Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: October 17, 2023
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Stefan Nikolaus Gradl, Duy Nguyen, Knut Eis, Judith Günther, Timo Stellfeld, Andreas Janzer, Sven Christian, Thomas Mueller, Sherif El Sheikh, Han Jie Zhou, Changjia Zhao, David B. Sykes, Steven James Ferrara, Kery Liu, Simon Anthony Herbert, Claudia Merz, Michael Niehues, Carl Friedrich Nising, Martina Schäfer, Katja Zimmermann, Jörg Knäblein, Kai Thede, Thomas Faupel
  • CAL-T CONSTRUCTS AND USES THEREOF
    Publication number: 20230321183
    Abstract: The technology described herein is directed to compositions comprising components of multi-component CALs or CARs, e.g., a TCR recognition domain; and one or both of: (a) an intracellular signaling domain; and (b) a first-type protein interaction domain. Further provided herein are methods for treating or preventing an autoimmune disease, a transplant rejection, or graft versus host disease.
    Type: Application
    Filed: June 16, 2023
    Publication date: October 12, 2023
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, THE GENERAL HOSPITAL CORPORATION
    Inventors: Mohammadreza PAKYARI, Wilson WONG, Atsushi OKUMA, Curtis CETRULO
  • METHOD FOR EXAMINING CELL AND DEVICE THEREOF
    Publication number: 20230326018
    Abstract: Disclosed is a method for examining cells including: acquiring image data of cells acquired from a region suspected to be a cancer lesion; analyzing the image data; determining whether an amount of the cells is sufficient based on the analyzed result; and determining whether cancer-probable cells are included in the cells based on the analyzed result and the determined result; wherein the cells are acquired through Fine Needle Aspiration (FNA).
    Type: Application
    Filed: February 10, 2023
    Publication date: October 12, 2023
    Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, THE GENERAL HOSPITAL CORPORATION
    Inventors: Moon Jae CHUNG, Hyungsoon IM
  • METHODS AND COMPOSITIONS RELATING TO EX VIVO CULTURE AND MODULATION OF T CELLS
    Publication number: 20230322923
    Abstract: Described herein are methods for producing and utilizing an artificial antigen presenting cell (aAPC). An aAPC is engineered to express a first and second chimeric stimulatory receptor that specifically bind antigen presenting on a T cell of interest. The aAPC as described herein is designed for use in activating and/or expanding a T cell or chimeric antigen receptor (CAR) T cell. Further, this invention relates to methods of treating cancer by administering to a subject in need thereof an aAPC-activated CAR T cell.
    Type: Application
    Filed: February 6, 2023
    Publication date: October 12, 2023
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Marcela V. Maus, Felipe Bedoya
  • Rare cell analysis using sample splitting and DNA tags
    Patent number: 11781187
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: October 10, 2023
    Assignees: The General Hospital Corporation, GPB Scientific, LLC, Verinata Health, Inc.
    Inventors: Daniel Shoemaker, Mehmet Toner, Ravi Kapur, Roland B. Stoughton, Ronald W. Davis
  • Analogues of parathyroid hormone (1-34) that function as agonists of the parathyroid hormone receptor-1 and display modified activity profiles
    Patent number: 11780901
    Abstract: Described are polypeptide analogs of parathyroid hormone (PTH) that include an unnatural amino acid substitution at positions 7 or 8 from the N-terminus of the polypeptide. Also described are pharmaceutical compositions useful for treating hypoparathyroidism that contain the analogs and methods of using the analogs to treat hypoparathyroidism.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: October 10, 2023
    Assignees: Wisconsin Alumni Research Foundation, The General Hospital Corporation
    Inventors: Samuel H. Gellman, Shi Liu, Thomas J. Gardella
  • Methods for determining a nucleotide sequence contiguous to a known target nucleotide sequence
    Patent number: 11781179
    Abstract: The technology described herein is directed to methods of determining oligonucleotide sequences, e.g. by enriching target sequences prior to sequencing the sequences.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: October 10, 2023
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Anthony John Iafrate, Long Phi Le, Zongli Zheng