Abstract: A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.
Type:
Application
Filed:
January 23, 2017
Publication date:
January 31, 2019
Applicants:
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALL A CONGRESSIOY CHARTERED NOT-FOR-PROFIT CORPORATIO, WASHINGTON UNIVERSITY IN ST. LOUIS
Inventors:
Cynthia DOWD, Audrey ODOM, Rachel Edwards, Robert BROTHERS