Patents Assigned to The Georgetown University
  • Histidine kinase two-component in Candida albicans
    Patent number: 6824992
    Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: November 30, 2004
    Assignees: Human Genome Sciences, Inc., The Georgetown University
    Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
  • Histidine kinase two-component in Candida albicans
    Patent number: 6416989
    Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: July 9, 2002
    Assignees: Human Genome Sciences, Inc., The Georgetown University
    Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
  • Histidine kinase two-component in Candida albicans
    Patent number: 6120999
    Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: September 19, 2000
    Assignees: Human Genome Sciences, Inc., The Georgetown University
    Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone