Patents Assigned to The Gov. of the USA as represented by the Secretary of the Dep. of Health and Human Services
  • VACCINES FOR BLOCKING TRANSMISSION OF PLASMODIUM VIVAX
    Publication number: 20080274132
    Abstract: The present invention relates novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface of Plasmodium vivax zygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.
    Type: Application
    Filed: July 2, 2008
    Publication date: November 6, 2008
    Applicant: The Gov. of the USA as represented by the Secretary of the Dep. of Health and Human Services
    Inventors: David C. KASLOW, Takafumi Tsuboi, Motomi Torii
  • Screening assays for compounds that cause apoptosis
    Publication number: 20040115747
    Abstract: This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.
    Type: Application
    Filed: August 4, 2003
    Publication date: June 17, 2004
    Applicant: The Gov. of the USA as represented by the Secretary of the Dep. of Health and Human Services
    Inventors: Curtis C. Harris, Xin Wei Wang, Jan H.J. Hoeijmakers