Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.
Type:
Application
Filed:
April 16, 2002
Publication date:
November 7, 2002
Applicant:
The Gov. of the USA respresented by the Secretary of Health and Human Services
Inventors:
Raymond W. Klecker, Lawrence Anderson, Aspandiar G. Katki, Jerry M. Collins