Abstract: High affinity antibodies were made to gangliosides expressed on tumor cells. The antibodies can be used analytically, diagnostically, therapeutically, and theranostically. The antibodies may be used to target cytotoxic reagents to tumor cells, thus minimizing full-body toxicity. The antibodies may also be used with out added cytotoxin. The antibodies may be detectably labeled or labelable for analytic and diagnostic purposes. The combination of specificity and affinity of the antibodies render them particularly useful.
Type:
Application
Filed:
November 15, 2011
Publication date:
January 9, 2014
Applicants:
The Gov't of the United States, as Represented by, The Secretary of Health and Human Services, DUKE UNIVERSITY
Inventors:
Darell Bigner, Chien-Tsun Kuan, Ira H. Pastan, Hailan Piao
Abstract: A method for reproducibly analyzing mass spectra from different sample sources is provided. The method deconvolutes the complex spectra by collapsing multiple peaks of different molecular mass that originate from the same molecular fragment into a single peak. The differences in molecular mass are apparent differences caused by different charge states of the fragment and/or different metal ion adducts and/or reactant products of one or more of the charge states. The deconvoluted spectrum is compared to a library of mass spectra acquired from samples of known identity to unambiguously determine the identity of one or more components of the sample undergoing analysis.
Type:
Application
Filed:
June 7, 2004
Publication date:
March 24, 2005
Applicant:
The Gov't of the United States, as represented by the Secretary of Health & Human Services
Inventors:
Alexandre Shvartsburg, Jon Wilkes, Paul Chiarelli, Ricky Holland, Dan Buzatu, Michael Beaudoin