Abstract: Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against Plasmodium falciparum, the most severe form of malaria. Conjugates of ookinete surface protein Pvs25 for use as a vaccine against Plasmodium vivax are also provided. Methods for preparing the conjugates, which comprise the ookinete surface protein bound onto itself or onto another protein by a linking group, are also provided.
Type:
Application
Filed:
October 15, 2007
Publication date:
July 22, 2010
Applicant:
The Govenment of the United States of America as represented by tge Secreatary of Health
Inventors:
Rachel Schneerson, Joanna Kubler-Kielb, Yimin Wu, Louis Miller, Fathy D. Majadly, John B. Robbins