Patents Assigned to THE GOVERMMENT of the USA as Represented by the Secretary of the Dept, of Health and Human Service
  • Specificity grafting of a murine antibody onto a human framework
    Publication number: 20060194276
    Abstract: The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework.
    Type: Application
    Filed: June 17, 2003
    Publication date: August 31, 2006
    Applicants: THE GOVERMMENT of the USA as Represented by the Secretary of the Dept, of Health and Human Service, University of Reading
    Inventors: Jurgen Krauss, Michaela Arndt, Andrew Martin, Susanna Rybak