Patents Assigned to The Government of the U.S. A, as presented by the Secretary, Department of Health and Human Services
  • cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product
    Publication number: 20040139485
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-&bgr;1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Application
    Filed: February 5, 2004
    Publication date: July 15, 2004
    Applicant: The Government of the U.S. A, as presented by the Secretary, Department of Health and Human Services
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang