Abstract: The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
Type:
Application
Filed:
July 26, 2013
Publication date:
November 14, 2013
Applicants:
The Government of the USA as represented by the Sec. of the Dept. of Health and Human Services, Masaryk Memorial Cancer Institute, The University of Dundee
Inventors:
Curtis C. Harris, Kaori Fujita, Izumi Horikawa, Barivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane