Patents Assigned to The Government of the U.S.A. as represented by the Secretary of the Department of Health and Human S
  • NITRITE AND NITRITE-METHEME THERAPY TO DETOXIFY STROMA-FREE HEMOGLOBIN BASED BLOOD SUBSTITUTES
    Publication number: 20170087181
    Abstract: This disclosure relates to methods of using nitrite to detoxify stroma-free hemoglobin based blood substitutes. In particular, methods are described for using a blood substitute comprised of about equimolar amounts of nitrite and hemoglobin (e.g., nitrite-metHb) to treat, prevent, or ameliorate diseases of the blood in a subject, or as a blood replacement in a subject.
    Type: Application
    Filed: May 4, 2016
    Publication date: March 30, 2017
    Applicants: The Government of the U.S.A. as represented by the Secretary of the Department of Health and Human S, The UAB Research Foundation, Wake Forest University
    Inventors: Mark T. Gladwin, Daniel B. Kim-Shapiro, Rakesh P. Patel, Jeffrey Kerby
  • LUTZOMYIA LONGIPALPIS POLYPEPTIDES AND METHODS OF USE
    Publication number: 20160279211
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishishmaniasis are disclosed.
    Type: Application
    Filed: June 7, 2016
    Publication date: September 29, 2016
    Applicants: The Government of the U.S.A. as represented by the Secretary of the Department of Health and Human S, Fundaçao Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes