Patents Assigned to THE GOVERNMENT OF THE U.S., as represented by the Sec. of the Dept. of Health and Human Services
  • USE OF NITRITE SALTS FOR THE TREATMENT OF CARDIOVASCULAR CONDITIONS
    Publication number: 20170281673
    Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
    Type: Application
    Filed: June 22, 2017
    Publication date: October 5, 2017
    Applicants: The Government of the U.S.A. as represented by the Sec. of the Dept. of Health and Human Services, Loma Linda University, Wake Forest University
    Inventors: Mark T. Gladwin, Alan N. Schechter, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Richard O. Cannon, III
  • Inhibitors of epoxide hydrolases for the treatment of hypertension
    Publication number: 20040092487
    Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension.
    Type: Application
    Filed: October 27, 2003
    Publication date: May 13, 2004
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE GOVERNMENT OF THE U.S., as represented by the Sec. of the Dept. of Health and Human Services
    Inventors: Deanna L. Kroetz, Darryl C. Zeldin, Bruce D. Hammock, Christophe Morisseau