Patents Assigned to The Government of the United State, as represented by the Secretary, Dept. of Health & Human Service
  • METHOD FOR TREATING ATHEROSCLEROSIS OR RESTENOSIS USING MICROTUBULE STABILIZING AGENT
    Publication number: 20140135386
    Abstract: The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefore. In particular, it is a method of preventing or reducing atherosclerosis or restenosis after arterial injury by treatment with a low dose of a microtubule stabilizing agent such as taxol or a water soluble taxol derivative. The low dose used in the present invention prevents artery blockage while minimizing any negative side effects associated with the drug.
    Type: Application
    Filed: May 29, 2013
    Publication date: May 15, 2014
    Applicant: The Government of the United States as Represented by the Secretary, Dept. of Health & Human Service
    Inventors: James L. Kinsella, Steven J. Sollott
  • cDNA Encoding a Gene Bog (B5T Over-Expressed Gene) and its Protein Product
    Publication number: 20100129791
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-?1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Application
    Filed: December 14, 2007
    Publication date: May 27, 2010
    Applicant: The Government of the United State, as represented by the Secretary, Dept. of Health & Human Service
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang
  • Infectious clone of human parvovirus B19 and methods
    Publication number: 20060008469
    Abstract: The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections.
    Type: Application
    Filed: July 9, 2004
    Publication date: January 12, 2006
    Applicant: Government of the United States, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Kevin Brown, Ning Zhi, Peter Tijssen, Zoltan Zadori