Patents Assigned to The Government of the United States, as represent- ed by the Secretary of Health and Human Services,
  • Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit ccr5-tropic hiv-1 infection and replication
    Publication number: 20050123510
    Abstract: It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
    Type: Application
    Filed: March 28, 2002
    Publication date: June 9, 2005
    Applicant: The Government of the United States, as represent- ed by the Secretary of Health and Human Services,
    Inventors: Leonid Margolis, Jean-Charles Grivel, Paolo Lusso