Patents Assigned to THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HHS, NIH
  • ANTI-PODOPLANIN ANTIBODIES AND METHODS OF USE
    Publication number: 20140017266
    Abstract: Recombinant scFv-immunotoxins target tumor cells expressing human podoplanin but not podoplanin-negative or normal cells. The immunotoxins can be used for treatment of malignant glioma patients or any malignant tumor expressing podoplanin. One such immunotoxin comprises a modified Pseudomonas exotoxin (PE38) attached to the scFv antibody fragment. This immunotoxin can be used as a therapeutic drug for the treatment of malignant gliomas and other cancers.
    Type: Application
    Filed: December 5, 2011
    Publication date: January 16, 2014
    Applicants: THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HHS, NIH, DUKE UNIVERSITY
    Inventors: Darell Bigner, Chien-Tsun Kuan, Ira H. Pastan, Vidyalakshmi Chandramohan