Patents Assigned to The Government of the United States as represented by the Secretary of the Department of Human Services
  • Retroviral packaging cassettes amplified in the cytoplasm by autocatalytic Togavirus vectors
    Patent number: 6489167
    Abstract: This invention provides a Togavirus-amplified retrovirus vector and a novel method for packaging a retrovirus cassette that contains a heterologous nucleic acid, which is amplified in a packaging cell cytoplasm by a Togavirus vector. The retroviral cassette is packaged into infectious retrovirus particles by retroviral packaging cells. These retroviral particles carrying the retroviral packaging cassette are then used to infect host cells.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: December 3, 2002
    Assignee: The Government of the United States as represented by the Secretary of the Department of Human Services
    Inventors: Richard Morgan, Jarmo Wahlfors, Kleanthis Xanthopoulos