Abstract: The present invention provides for nucleic acids improved for the expression of interleukin-12 (IL-12) in mammalian cells. The invention further provides for methods of expressing IL-12 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-12 sequence.
Type:
Application
Filed:
January 12, 2007
Publication date:
May 28, 2009
Applicant:
The Government of the United States of America, as a representative by the Secretary of the Depart
Inventors:
Barbara Felber, George N. Pavlakis, Margherita Rosati