Abstract: Described herein is Zscan4, a gene exhibiting 2-cell embryonic stage and embryonic stem cell specific expression. Identification of nine Zscan4 co-expressed genes is also described Inhibition of Zscan4 expression inhibits the 2-cell to 4-cell embryonic transition and prevents blastocyst implantation, expansion and outgrowth. Provided herein are methods of inhibiting differentiation of a stem cell, promoting blastocyst outgrowth of embryonic stem cells and identifying a subpopulation of stem cells expressing Zscan4. Further described is the identification of Trim43 as a gene exhibiting morula-specific expression. Also provided are isolated expression vectors comprising a Zscan4 promoter, or a Trim43 promoter operably linked to a heterologous polypeptide and uses thereof. Further provided are transgenic animals comprising transgenes encoding marker proteins operably linked to Zscan4 and Trim43 promoters.
Type:
Application
Filed:
December 30, 2013
Publication date:
May 1, 2014
Applicant:
The Government of the United States of America as represented by the Department of Health and Human
Abstract: Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.
Type:
Application
Filed:
November 8, 2013
Publication date:
March 6, 2014
Applicants:
The Government of the United States of America as Represented by the Department of Health and Human, UNIVERSITY OF MARYLAND COLLEGE PARK
Inventors:
Benjamin Shapiro, Michael R. Emmert-Buck
Abstract: Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of stem cells, such as adult stem cells, optionally with cytokines are disclosed and claimed.
Type:
Application
Filed:
May 5, 2003
Publication date:
April 22, 2004
Applicants:
The Government of the United States of America as represented by the Department of Health and, Human Services
Abstract: A method for predicting breast tumor metastasis entails determining the amount of met protein in tumor tissue relative to normal breast duct tissue.
Type:
Grant
Filed:
June 26, 1992
Date of Patent:
January 6, 2004
Assignee:
The Government of the United States of America as represented
by the Department of Health and Human Services
Inventors:
Ilan Tsarfaty, James H. Resau, Iafa Keydar, Donna Faletto, George F. Vande Woude
Abstract: The present invention relates, in general, to prodrugs. In particular, the present invention relates to lipophilic, aminohydrolase-activated, anti-viral nucleoside prodrug compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds.
Type:
Grant
Filed:
April 10, 1991
Date of Patent:
October 17, 1995
Assignee:
The Government of the United States of America as represented by the Department of Health and Human Services
Inventors:
Victor E. Marquez, John S. Driscoll, Harry Ford, Jr., James A. Kelley, Joseph J. Barchi, Jr., Hiroaki Mitsuya, Christopher K-H. Tseng, David G. Johns, Joseph E. Tomaszewski