Patents Assigned to The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services
-
Patent number: 5465013Abstract: An electric field shield for non-grounded AC powered appliances is connected to a neutral return terminal of the AC power distribution system. A polarized two prong connector assures connection of the shield to neutral. By eliminating a requirement for connection of the shield to ground, shields are made available for appliances precluded from ground connection such as bedding heaters. A double pole control switch is included to eliminate E-field generation in an OFF state caused by improper wiring or the use of unpolarized intermediate connectors. The shield is insulated and a current limiting device is series connected between the shield and neutral to reduce electrical hazards.Type: GrantFiled: July 12, 1993Date of Patent: November 7, 1995Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Howard I. Bassen, John P. Casamento
-
Patent number: 5378602Abstract: The invention relates to polymorphic markers (two tetranucleotide, one dinucleotide repeat polymorphisms and 27 markers characterized by primer pairs 1A-27A) that are useful for human individualization. Applications are in forensic medicine and for paternity and prenatal screening as well as genetic mapping. These markers are characterized by sets of oligonucleotide primers according to the invention useful in PCR amplification and DNA segment resolution.Type: GrantFiled: November 27, 1991Date of Patent: January 3, 1995Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Michael H. Polymeropoulos, Carl R. Merril
-
Patent number: 5308753Abstract: Methods for purifying and detecting IgM antibodies employ binding substances which are Borellia burgdorferi cells, or cellular or extracellular components obtained or derived therefrom and which bind to this class of antibodies. The binding substances may be attached to a solid substrate and then the substrate contacted with a solution containing IgM antibodies under conditions such that the antibodies bind to the binding substance on the substrate. The substrate is then contacted with a solution that releases the IgM antibodies from the substrate and the antibodies are recovered or detected. Applications of these methods include, for example, assays for diagnosing diseases which elicit primary and/or secondary IgM antibody-mediated immunity.Type: GrantFiled: February 20, 1992Date of Patent: May 3, 1994Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: David W. Dorward, Edward D. Huguenel, Gary Davis, Claude F. Garon
-
Patent number: 5294604Abstract: The present invention provides a method of treating ocular diseases by the administration of cyclosporine A or G by periocular injection in a pharmaceutically acceptable carrier.Type: GrantFiled: December 20, 1989Date of Patent: March 15, 1994Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Robert B. Nussenblatt, Alan G. Palestine
-
Patent number: 5250550Abstract: There are disclosed novel complexes of nitric oxide and polyamines which are useful in treating cardiovascular disorders, including hypertension. The disclosed compounds release nitric oxide (endothelium-derived relaxing factor) under physiological conditions in a sustained and controllable fashion, and possess long mechanisms of action.Type: GrantFiled: June 30, 1992Date of Patent: October 5, 1993Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Larry K. Keefer, Joseph A. Hrabie
-
Patent number: 5235416Abstract: A system is provided for performing simultaneous bilateral measurements on a subject in motion at a test location. The system employs a plurality of observed targets attached to the moving subject, the targets being viewed simultaneously by each of two cameras disposed on opposite sides of the subject. Each of the cameras has associated therewith a light source emitting a light of a selected wavelength, the wavelengths for the two cameras being deliberately selected to be different enough to enable each camera to image the light source of the other without corruption of the observed data. The simultaneously operating two camera units may be computer controlled in preprogrammed manner or may be controlled by the operation of a manual control panel. In either case, the overall intensity of the two light sources providing illumination at the two selected different wavelengths facilitates the provision of illumination which avoids confusion by reflectance from the subject at other than the selected targets.Type: GrantFiled: July 30, 1991Date of Patent: August 10, 1993Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health & Human ServicesInventor: Steven J. Stanhope
-
Patent number: 5203339Abstract: Imaging of a turbid object utilizes interference among the modulation wavefronts of a plurality of modulated light rays propagating through the object by diffusion and having predetermined phases relative to one another. A computer controlled phase and amplitude selecting device, such as a zone plate, is used to modulate light rays at appropriate phases in order to obtain constructive interference only at a predetermined portion of the object, including one or more preselected voxels. The rays reflected from (or diffusively transmitted through) the predetermined portion are received simultaneously at a detector, thus providing simultaneously all the data necessary to describe or image the portion. A single detector element may be used to detect the scattered reflected or transmitted light from the portion and to generate a signal representing the amplitude and phase characteristics for the modulation wavefront, thereby to provide absorption (and other) characteristics descriptive of the portion.Type: GrantFiled: June 28, 1991Date of Patent: April 20, 1993Assignee: The Government of the United States of America as represented by the Secretary of the Department Health and Human ServicesInventors: Alexander Knuttel, Jay R. Knutson
-
Patent number: 5151188Abstract: A method for enhancing supercritical fluid extraction of sample matrices which contain water. The method involves mixing the samples with an extraction enhancing aid comprising flux-calcined diatomaceous earth which increases the permeability of the sample in a supercritical fluid and controls water during the extraction procedure.Type: GrantFiled: June 12, 1990Date of Patent: September 29, 1992Assignee: The Government of the United States of America, as represented by the Secretary of the Department of Health and Human ServicesInventors: Marvin L. Hopper, Jerry W. King
-
Patent number: 5126129Abstract: Treatment of Cancer with Flavones and Interleukin 2.Type: GrantFiled: February 4, 1991Date of Patent: June 30, 1992Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health & Human ServicesInventors: Robert H. Wiltrout, Ronald Hornung
-
Patent number: 5092885Abstract: Peptides with laminin activity are provided as follows:tyrosine-isoleucine-glycine-serine-arginine;proline-aspartine-serine-glycine-arginine; andcysteine -aspartate-proline-glycine-tyrosine-isoleucine-glycine-serine-arginine.These peptides block angiogenesis, alter the formation of capillary structures by endothelial cells, prevent the formation of excess blood vessels in tissues, and inhibit in vivo tumor cell colonization of tissues.Type: GrantFiled: November 16, 1988Date of Patent: March 3, 1992Assignee: The Government of the United States of America as Represented by the Secretary of the Department of Health and Human ServicesInventors: Yoshihiko Yamada, Jeannette O. Graf, Yukihide Iwamoto, Frank Robey, Hynda K. Kleinman, Makoto Sasaki, George R. Martin
-
Patent number: 5078553Abstract: An apparatus for sampling and collecting wood samples for analysis purposes which includes a boring bit surrounded by a chamber into which the boring bit draws samples and from which the samples are passed to a collection container. The boring bit is housed in a pair of slidably connected housing members which determine the depth that the boring bit enters a wood sample. Collected samples are analyzed for microbial contaminates.Type: GrantFiled: February 6, 1990Date of Patent: January 7, 1992Assignee: The Government of the United States of America, as represented by the Secretary of the Department of Health and Human ServicesInventors: Jacek Dutkiewicz, Czeslaw Kwapiszewski, Stephen A. Olenchock, Daniel Lewis
-
Patent number: 5030642Abstract: The present invention relates to a method of inhibiting tumor metastasis in an aminal by administering to an animal in need of such treatment an acrylaminoalkylpryridineamides represented by the formula ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided n+m+p is equal to or less than 10; x is thio or sulfinyl; Alk.sub.1 is straight or branched chain lower alkylene of 1 to 6 carbon atoms, R.sub.3 is hydrogen or lower alkyl, Alk.sub.2 is straight or branched chain alkylene of 1 to 4 carbon atoms; R.sub.4 is selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl and lower alkoxy; or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit tumor metastasis.Type: GrantFiled: December 2, 1988Date of Patent: July 9, 1991Assignees: G. D. Searle & Co., The Government of the United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: George C. Fuller, George R. Martin, Richard A. Mueller, Reuven Reich
-
Patent number: 4968692Abstract: A method is provided for attenuating the intoxicating effects of ethyl alcohol in a patient, by administering to a patient in need thereof, an alpha-2 adrenoceptor antagonist compound. Two preferred compounds useful in the present invention, each being a highly potent and selective alpha-2 adrenoceptor antagonist, are atipamezole and idazoxan.Type: GrantFiled: January 6, 1989Date of Patent: November 6, 1990Assignee: The Government of the United States of America, as represented by the Secretary of the Department of Health and Human ServicesInventors: Markku Linnoila, Richard G. Lister, Michael J. Durcan
-
Patent number: 4693994Abstract: The present invention discloses a synthetic peptide capable of inducing antibodies protective against human malarial infection caused by Plasmodium vivax sporozoites and the cloning of a gene encoding said peptide. The amino acid and nucleotide sequences of the peptide and the gene, respectively, have been determined and described.Type: GrantFiled: November 19, 1985Date of Patent: September 15, 1987Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Thomas F. McCutchan, Richard Wistar, Jr.
-
Patent number: 4397310Abstract: An improved method and apparatus for photocoagulation of the fundus of a patient's eye eliminates the contact lens and provides for binocular viewing. The technique is characterized by the utilization of a common ophthalmoscopic lens for each of the illumination beam, the observation beam, and the laser beam. A scanning mirror for the laser beam is disposed on the optical axis and is rotatable in two dimensions about a fixed point which is conjugated with the nodal point of the patient's eye with respect to the ophthalmoscopic lens. The binocular viewing paths are converged onto a point on the optical axis in the plane of the first aerial image of the fundus provided by the ophthalmoscopic lens; the laser beam reflected by the scanning mirror is also focused onto that point.Type: GrantFiled: February 27, 1981Date of Patent: August 9, 1983Assignee: The Government of the United States of America as represented by the Secretary of Department of Health and Human ServicesInventor: Oleg Pomerantzeff