Patents Assigned to The Government of the United States of America, as represented by The Secretary HHS and NIH of Tec
  • Enhanced hiv-1 vaccines and methods for their use
    Publication number: 20060188884
    Abstract: The present invention provides peptides and proteins for use in second generation HIV vaccines and as diagnostic tools in the treatment and control of HIV infection. The antiviral protection shown by compositions of the present invention has not been previously achieved with an HLA epitope-enhanced vaccine. These findings define a critical balance between MHC affinity and receptor crossreactivity required for effective epitope enhancement and also demonstrate construction and efficacy of such a component of a new generation vaccine.
    Type: Application
    Filed: March 29, 2004
    Publication date: August 24, 2006
    Applicant: The Government of the United States of America, as represented by The Secretary HHS and NIH of Tec
    Inventors: Jay Berzofsky, Takahiro Okazaki