Patents Assigned to The Government of the United States of America as represented by The Secretary of The Department of Health and Human Services, The National Institutes of Health
  • Plasma cell cytokine vehicle containing fusion proteins for targeted introduction of siRNA into cells and tissues
    Patent number: 10485879
    Abstract: A fusion molecule is provided that includes one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety. The targeting polypeptide and the nucleic acid binding moiety include specific the amino acid sequences. A fusion molecule is also provided that includes one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety adapted to bind a double-stranded RNA or to a small hairpin RNA. The targeting polypeptide being CCL27 or CCL11 or a fragment thereof.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: November 26, 2019
    Assignees: Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health
    Inventors: Bira Arya, Michael R. Simon
  • Recombinant MVA viruses expressing clade A/G, clade B, and clade C modified HIV env, gag and pol genes
    Patent number: 9453239
    Abstract: The invention provides modified vaccinia Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Grant
    Filed: August 29, 2005
    Date of Patent: September 27, 2016
    Assignees: Emory University, The Government of the United States of America, as represented by the Secretary Department of Health and Human Services, National Institutes of Health
    Inventors: Bernard Moss, Linda Wyatt, Harriet L. Robinson
  • Cyanovirin variant-polymer conjugates
    Patent number: 7267941
    Abstract: The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water soluble polymers, to provide polymer conjugates of cyanovirin-N variants exhibiting antiviral activity.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: September 11, 2007
    Assignees: The Government of the United States of America as represented by The Secretary of The Department of Health and Human Services, The National Institutes of Health, Nektar Therapeutics AL
    Inventors: M. Elizabeth Snell, Michael J. Roberts, Toshiyuki Mori, Barry R. O'Keefe, Michael R. Boyd