Patents Assigned to The Government of the United States of Americam as Represented by the Secretary of the Navy
  • Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential
    Patent number: 10705092
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 7, 2020
    Assignee: The Government of the United States of Americam as Represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson