Patents Assigned to The Government of the US, as represented by the Secretary, Department of Health and Human Services
  • Biomarkers for Tissue Status
    Publication number: 20090258002
    Abstract: The invention relates to methods of accurately and quickly diagnosing and monitoring the progression of cancer and ischemally injured tissue. The invention also provides methods of treatment as well as methods of screening for compositions useful for treating the disorders.
    Type: Application
    Filed: February 1, 2006
    Publication date: October 15, 2009
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: J. Carl Barrett, Joseph Riss
  • Broad Spectrum Antiviral Compositions
    Publication number: 20090214510
    Abstract: The instant invention provides compositions and methods for the treatment of viral infections caused by enveloped viruses comprising phospholipase nucleic acid molecules or polypeptides, or fusion molecules comprising phospholipase molecules or functional fragments thereof.
    Type: Application
    Filed: February 21, 2007
    Publication date: August 27, 2009
    Applicant: Government of the US as represented by the Secretary, Department of Health and Human Services
    Inventors: Gary J. Nabel, Jae Ouk Kim
  • Treating or Preventing Renal Cancer Using a Dimethane Sulfonate
    Publication number: 20090131536
    Abstract: The present invention features methods of treating renal cancer by administration of certain dimethylsulfonate compounds. The present invention further features administration protocols and dosing schedules for methods of treating patients suffering from renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.
    Type: Application
    Filed: October 14, 2005
    Publication date: May 21, 2009
    Applicant: GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Susan D. Mertins, Susan E. Bates, David G. Covell, Geoffrey W. Patton, Melinda G. Hollingshead, Rao Vishnuvajjalla
  • Methods and compositions for the treatment and prevention of cancer
    Publication number: 20090068234
    Abstract: The instant invention provides compositions for the treatment of cancer. Specifically, the invention provides polypeptides and nucleic acid molecules comprising tumor-associated embryonic antigens, e.g., OFA-iLRP, and chemoattractant ligands, e.g., a proinflammatory chemokine such as MIP3?/CCL20 or ?-defensin mDF2?. The invention further provides cancer vaccines and methods for treating subjects having, or at risk of developing, cancer.
    Type: Application
    Filed: September 3, 2007
    Publication date: March 12, 2009
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Arya Biragyn, Dan Longo, Igor Espinoza-Delgado
  • Methods for Detecting Progression of Low Grade Cervical Dysplasia and for Detecting Adenocarcinomas
    Publication number: 20090035763
    Abstract: The invention provides methods for identifying conditions of low grade cervical dysplasia and assessing the progressive potential of individual lesions to develop into high grade cervical dysplasia and cervical squamous cell cancer as well as cervical adenocarcinoma.
    Type: Application
    Filed: February 21, 2006
    Publication date: February 5, 2009
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Thomas Reid, Kerstin Heselmeyer-Haddad, Winfried Steinberg, Gert Auer, Sonia Andersson, Catharina Larsson
  • Hydrophilic IR Transparent Membrane, Spectroscopic Sample Holder Comprising Same and Method of Using Same
    Publication number: 20080311616
    Abstract: The present invention features hydrophilic IR-transparent porous membranes, particularly hydrophilic IR-transparent porous polyethylene membranes and methods of preparing the hydrophilic membranes by treatment of hydrophobic IR-transparent porous membranes with plasma. The present invention further features spectroscopic sample holders which incorporate the hydrophilic IR-transparent porous membranes and methods of identifying bacteria and other microorganisms in samples by infrared spectroscopy.
    Type: Application
    Filed: April 23, 2008
    Publication date: December 18, 2008
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Magdi Mossoba, Suflan Al-Khaldi
  • Inhibitors of ubiquitin E1
    Publication number: 20080306130
    Abstract: The present invention features pyrazolidinyl compounds, pharmaceutical compositions of substituted pyrazolidinyl compounds and methods of treating a patient suffering from cancer or viral infection, the method comprising administering to a patient one or more pyrazolidinyl compounds of the invention.
    Type: Application
    Filed: May 19, 2008
    Publication date: December 11, 2008
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Allan M. Weissman, Yili Yang, Jane P. Jensen
  • Maleiimide anti-tumor phosphatase inhibitors
    Publication number: 20080039518
    Abstract: The present invention features maleiimide compounds, pharmaceutical compositions of maleiimide compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more maleiimide compounds of the invention.
    Type: Application
    Filed: August 22, 2006
    Publication date: February 14, 2008
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Christopher Michejda, Wei Yao, Brian Carr, Siddhartha Kar, Maria Michejda
  • Steroid Formulation And Methods Of Treatment Using Same
    Publication number: 20080008762
    Abstract: The invention provides steroid-containing pharmaceutical compositions which are free of classical preservatives and preferably comprise a steroid that is sparingly soluble or substantially insoluble in water, particulate steroid having an average particle size of from about 2.2 to about 10 microns. The pharmaceutical compositions can be used to treat medical conditions, including ophthalmological and back pain conditions.
    Type: Application
    Filed: November 17, 2005
    Publication date: January 10, 2008
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Michael Robinson, George Grimes, Luisa Gravlin, Gopal Potti, Peng Yuan, Karl Csaky
  • Protein tyrosine kinase substrate lat and its use in the identification of (ANT)agonists of the kinase
    Publication number: 20070134749
    Abstract: The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their intracellular ligands and other members of the signaling pathway.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 14, 2007
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Lawrence Samelson, Weiguo Zhang
  • Hiv-dependent expression constructs and uses therefor
    Publication number: 20070134767
    Abstract: The present invention provides nucleic acid molecules comprising expressible sequences, including reporter genes and therapeutic genes, whose expression is dependent on the presence of both HIV Tat and Rev proteins. Further provided are methods for detecting HIV, method for identifying compounds that can inhibit HIV infection and/or gene expression, methods for killing HIV-infected cells, and methods of treating HIV-infected subjects.
    Type: Application
    Filed: September 28, 2004
    Publication date: June 14, 2007
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Yuntao Wu, Jon Marsh
  • Novel form of interleukin-15, Fc-IL-15, and methods of use
    Publication number: 20060257361
    Abstract: The present invention relates to Fc-IL-15 hybrids, which may or may not include peptide linkers between the IL-15 and the Fc portion, for methods of treatment of tumors and viral infections. The IL-15 hybrids can be Fc-IL-15 or IL-15-Fc hybrids. The Fc-IL-15 hybrids include variants, including the IL-15 and Fc variants. The hybrids preferably (but not necessarily) include peptide linkers between the IL-15 and the Fc portion. These linkers are preferably composed of a T cell inert sequence, or any non-immunogenic sequence.
    Type: Application
    Filed: April 12, 2006
    Publication date: November 16, 2006
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Morihiro Watanabe, Hiroshi Yazawa, John Ortaldo, Robert Wiltrout
  • Protozoan derived compositions and methods for treating autoimmune disease
    Publication number: 20060148696
    Abstract: The instant invention relates to methods for treating a subject suffering from or susceptible to an autoimmune disease or disorder, or a disease or disorder having an autoimmune component, comprising administering to the subject an effective amount of cyclophilin or a biologically active fragment thereof.
    Type: Application
    Filed: July 8, 2005
    Publication date: July 6, 2006
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Julio Aliberti, Jose Riberio, John Andersen, Hana Golding, Alan Sher
  • Recombinant vaccine viruses expressing il-15 and methods of using the same
    Publication number: 20060147419
    Abstract: The invention is directed to compositions capable of augmenting the immunogenicity of a vaccine. The composition, or adjuvant, is administered to a mammal in need thereof in sequential or concurrent combination with a vaccine antigen. In one preferred aspect, the adjuvant is provided in the form of a recombinant poxvirus vector, such as a vaccinia virus vector, which comprises a nucleic acid sequence encoding IL-15.
    Type: Application
    Filed: December 15, 2003
    Publication date: July 6, 2006
    Applicant: GOVERNMENT of the US, as represented by the Secretary , Department of Health and Human Service
    Inventors: Liyange Perera, Thomas Waldmann, Sang-Kon Oh, Jay Berzofsky