Abstract: The disclosure relates to modified apelin polypeptides having increased stability against kallikrein, NEP and ACE2 degradation and/or potency relative to the native apelin-13 and apelin-17 polypeptides. Embodiments also disclose methods of using the polypeptides for treating cardiovascular disorders.
Type:
Grant
Filed:
July 3, 2018
Date of Patent:
May 5, 2020
Assignee:
THE GOVERNORS OF THE UNIV OF ALBERTA TEC EDMONTON
Inventors:
Gavin Oudit, John Vederas, Shaun McKinnie, Conrad Fischer