Abstract: The present invention relates to immunotoxins, that effectively kill malignant cells having a given surface marker and nucleic acid constructs encoding them. These reagents comprise a toxic moiety that is derived from a Rana pipiens protein having ribonucleolytic activity linked to an antibody capable of specific binding with a chosen tumor cell.
Type:
Application
Filed:
July 11, 2005
Publication date:
November 10, 2005
Applicants:
The Govt. of the U.S.A as represented by the Sect. of the Dept. of Health & Human Services, Inc, Immunomedics, Inc.
Inventors:
David Goldenberg, Susanna Rybak, Dianne Newton