Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
July 9, 2004
July 5, 2007
The Govt. of the U.S.A. through The Dept. of Health and Human Services, The University of Alabama Research Foundation, Wake Forest University, Loma Linda University, The Board of Supervisors of Louisiana State University
Mark Gladwin, Alan Schechter, David Lefer, Rakesh Patel, Christian Hunter, Gordon Power, Daniel Kim-Shapiro, Ryszard Pluta, Edward Oldfield, Richard Cannon