Patents Assigned to The Health Research Board
  • METHODS AND MATERIALS FOR IDENTIFYING POLYMORPHIC VARIANTS, DIAGNOSING SUSCEPTIBILITIES, AND TREATING DISEASE
    Publication number: 20110177958
    Abstract: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 21, 2011
    Applicants: The United States of America, as represented by Secretary, Department of Health and Human Services, The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, The Health Research Board
    Inventors: Lawrence C. BRODY, Anne PARLE-MCDERMOTT, John SCOTT, Peadar KIRKE, James MILLS, Faith PANGILINAN, Anne MOLLOY
  • Methods and materials for identifying polymorphic variants, diagnosing susceptibilities, and treating disease
    Patent number: 7879551
    Abstract: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: February 1, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Health Research Board
    Inventors: Lawrence C. Brody, Anne Parle-McDermott, John Scott, Peadar Kirke, James Mills, Faith Pangilinan, Anne Molloy
  • METHODS AND MATERIALS FOR IDENTIFYING POLYMORPHIC VARIANTS, DIAGNOSING SUSCEPTIBILITIES, AND TREATING DISEASE
    Publication number: 20080213775
    Abstract: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTBFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.
    Type: Application
    Filed: December 17, 2007
    Publication date: September 4, 2008
    Applicants: Government of the United States of America, represented by the Secretary, Dept. of Health and, The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, The Health Research Board
    Inventors: Lawrence C. BRODY, Anne PARLE-MCDERMOTT, John SCOTT, Peadar KIRKE, James MILLS, Faith PANGILINAN, Anne MOLLOY