Abstract: Disclosed herein are genetically modified plants having altered biological activity of 3-?-hydroxysteroid dehydrogenase/isomerase (GAME25), or 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plants have an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Further disclosed herein are genetically modified plants having altered expression of a gene encoding a 3-?-hydroxysteroid dehydrogenase/isomerase (GAME25), or a 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plant has an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof.

Abstract: The present invention provides arylated fenchone derivatives, compositions comprising them, processes for their preparation and uses thereof.

Abstract: The invention provides compounds and uses thereof in the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy or oxidative stress, and methods of their preparation.

Abstract: The present invention provides compositions and methods for preserving pancreatic ?-cell populations and for the treatment of diabetes. In particular, embodiments of the invention relate to the use of newly identified prostaglandin receptor 3 (EP3) antagonists that are exceptionally effective in enhancing the viability and/or activity of pancreatic P cells.

Abstract: The invention relates to a block co-polymer film having different morphologies within said film, uses thereof and processes for its preparation.

Abstract: The invention provides cannabinoid derivatives, methods of their preparation, compositions comprising them and uses thereof in the treatment of inflammation and/or pain and/or obesity.

Abstract: The present invention provides nanoparticle carriers of active agents which are functionalized by stimuli-responsive conjugation with DNA-nano structures, methods and processes for their preparation, compositions comprising them and uses thereof in methods of treating diseases, disorders and symptoms thereof.

Abstract: Small molecule inhibitors (SMIs) of the Prolactin receptor, pharmaceutical compositions of the SMIs, and methods for treating patients suffering from disorders characterized increased expression or excitation of the Prolactin receptor, including breast cancer, prostate cancer and nociceptive pain disorders such as migraine headache, by administering pharmaceutical compositions of SMIs are provided.

Abstract: The present invention provides microcapsules encapsulating hydrophilic or hydrophobic active agents in an inorganic shell, processes for their preparation and compositions comprising them.

Abstract: The invention provides compositions comprising ladostigil, being a colonic delivery composition, including methods and uses thereof.

Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.

Abstract: The invention provides a process for the preparation of bismuth oxyhalide, comprising a precipitation of bismuth oxyhalide in an acidic aqueous medium in the presence of a reducing agent. Also provided are bismuth oxyhalide compounds doped with elemental bismuth Bi(0). The use of Bi(0)doped-bismuth oxyhalide as photocatalysts in water purification is also described.

Abstract: The invention relates to a block co-polymer film having different morphologies within said film, uses thereof and processes for its preparation.

Abstract: The invention provides compositions comprising at least one cannabinoid compound, for use in the method of treating and preventing a disease, condition or symptom caused by, or associated with fungi, bacteria and microbes.

Abstract: An optically active structure and a display device are presented. The device utilized an optically active structure comprising liquid crystal material and a plurality of nanorods configured to emit light in one or more predetermined ranges in response to pumping light. Variation in orientation of the liquid crystal varies orientation of the nanorods and modulated light emission therefrom.

Abstract: Small molecule inhibitors (SMIs) of the Prolactin receptor, pharmaceutical compositions of the SMIs, and methods for treating patients suffering from disorders characterized increased expression or excitation of the Prolactin receptor, including breast cancer, prostate cancer and nociceptive pain disorders such as migraine headache, by administering pharmaceutical compositions of SMIs are provided.

Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.

Abstract: The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.

Abstract: The present invention provides processes for the preparation of diverse heterocyclic scaffolds from alpha-enaminone building bloc of formula (I).

Abstract: A computer implemented method for performing fault tolerant numerical linear algebra computation task consisting of calculation steps that include at least classic or fast matrix multiplication, according to which, a controller splits the task among P processors, which operate in parallel. Additional processors are assigned according to execution and resources parameters, which are also used to select a slice-coded recovery algorithm or a posterior-recovery algorithm for executing the task. Pipelined-reduce operations are used to generate error correcting codes to protect the input blocks and outer products from faults. Upon detecting faults in one or more processors, if the slice-coded recovery algorithm has been selected, a slice-coded recovery algorithm is executed to recover lost input blocks and outer products that.