Abstract: The invention relates to compounds, compositions and methods for activating, reactivating, reversing or preventing the deactivation of cholinesterases, such as acetylcholinesterase and butyrylcholinesterase.
Type:
Application
Filed:
June 16, 2017
Publication date:
November 14, 2019
Applicants:
The Henry M. Jackson Foundation for the Advancemen t of Military Medicine, Inc., The Government of the United States as Represented by the Secretary of the Army
Abstract: Selective azophenol inhibitors of a wild type or an altered ERG protein expression are described, where the inhibitors represent a compound of Formula (I) or Formula (II) wherein X, X1, X2, X3, X4 and X5, R1 through R4 and R9 are as described.
Type:
Application
Filed:
February 15, 2019
Publication date:
November 7, 2019
Applicant:
The Henry M. Jackson Foundation for the Advancemen t of Military Medicine, Inc.
Inventors:
Albert L. DOBI, Clifton L. DALGARD, Shiv K. SRIVASTAVA
Abstract: Life-threatening traumas such as terrorist attacks, war, disasters, mental or physical assault, severe accidents and violence frequently provoke emotional and behavioral disturbances known as post-traumatic stress disorder (PTSD) and suicide related thereto. Accurate diagnosis and treatment planning for PTSD and suicide remain difficult. The discovery of specific markers creates new opportunities for more accurate clinical assessments identifying groups that may experience better outcomes when exposed to an intervention. The present invention provides a process of detection of P-11, UBE3A, STY1, EMAP-II, SIP1, ORC5L, DCX, SCYE protein in a biological sample of a subject suspected of suffering from PTSD and/or having suicidal tendencies, and provides additional PTSD markers which are specific to gender.
Type:
Application
Filed:
February 23, 2017
Publication date:
August 24, 2017
Applicants:
BANYAN BIOMARKERS, INC., THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMEN OF MILITARY MEDICINE, INC.
Inventors:
Harvey POLLARD, Lei ZHANG, Ofer EIDELMAN, Robert J. URSANO, He LI, Tung-Pi SU, Kevin Ka-Wang WANG, Ronald L. HAYES
Abstract: The invention described herein provides novel peptides. The novel peptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Nipah virus and/or Hendra virus.
Type:
Application
Filed:
April 9, 2013
Publication date:
March 6, 2014
Applicant:
The Henry M. Jackson Foundation for the Advancemen t of Military Medicine, Inc.
Inventors:
Christopher C. Broder, Deborah L. Fusco, Kai Hu, Dimitar B. Nikolov
Abstract: Provided are methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER/neu oncogene, GP2, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission, including patients having low to intermediate levels of HER2/neu expression. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as GM-CSF, and the GP2 peptide. The methods may further comprise administering a periodic booster vaccine dose as needed due to declining GP2-specific T cell immunity. Also provided are vaccine compositions for use in the methods.
Type:
Application
Filed:
December 9, 2009
Publication date:
October 20, 2011
Applicant:
The Henry M. Jackson Foundation for the Advancemen t of Military Medicine, Inc.
Abstract: This invention relates to soluble forms of G glycoprotein from Hendra and Nipah virus. In particular, this invention relates to compositions comprising soluble forms of G glycoprotein from Hendra and Nipah virus and also to diagnostic and therapeutic methods using the soluble forms of G glycoprotein from Hendra and Nipah virus. Further, the invention relates to therapeutic antibodies including neutralizing antibodies, and vaccines for the prevention and treatment of infection by Hendra and Nipah viruses.
Type:
Application
Filed:
July 7, 2005
Publication date:
February 12, 2009
Applicant:
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMEN
Inventors:
Christopher C. Broder, Katharine N. Bossart