Patents Assigned to The Hong Kong Polytechinc University
  • Method of biosynthesizing tetrodotoxin
    Publication number: 20080206825
    Abstract: The present invention relates methods for the biosynthesis of tetrodotoxin (TTX) involving the steps of obtaining a culture possessing one or more of a Vibrio species, such as through a seed culture, inoculating the culture and tissue extract from a textrodotoxin-bearing organism in a fermenter medium, and isolating and purifying tetrodotoxin from said fermenter, resulting in a yield of TTX of about 0.5 g TTX/L in about 3 to 5 days, such TTX being at least 90% pure.
    Type: Application
    Filed: February 23, 2007
    Publication date: August 28, 2008
    Applicant: The Hong Kong Polytechinc University
    Inventors: Peter Hoi-fu Yu, Chun Fai Yu