Patents Assigned to The Hong Kong University of Science and Technology
  • Patent number: 12007388
    Abstract: The invention relates to the systems and methods for isolating single cells, capturing selected prey biomolecules within said cells, and detecting said prey biomolecules using a sensitive assay method. Also described herein are functionalized substrates and compositions for enabling the low limit of detection of selected prey biomolecules of selected cells.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: June 11, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Pingbo Huang, Qirui Zhao
  • Patent number: 12000820
    Abstract: A multifunctional and modular geotechnical testing device for testing a soil sample is provided. The testing device includes a testing cell, a plurality of needle probes, and a plurality of lateral pressure-measuring sensors. The testing cell has an oedometer ring for accommodating the soil sample, with a plurality of holes located on and angularly distributed over an internal lateral surface of the oedometer ring forming a plurality of channels to access the soil sample from outside. The plurality of needle probes, each configured to house a pore water pressure-measuring sensor, is detachably mountable to the plurality of channels from outside for simultaneously measuring the pore water pressures. The plurality of lateral pressure-measuring sensors is removably attachable to an inner peripheral side of the testing cell for measuring lateral pressures of the soil sample.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: June 4, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Jun Kang Chow, Yu Hsing Wang
  • Patent number: 11965204
    Abstract: The subject invention pertains to composition and methods of using said composition as an in vitro biosensor of small molecules in biological and/or environmental samples using enzyme-assisted nucleic acid reactions. The methods and compositions can be used to sense and/or transduce the signal of a sensing event mediated by allosteric proteins, endonucleases and nucleic acid reactions. This invention allows the rapid development and setup of one-pot assays to provide results in minutes. The methods and compositions may be used to generate an electrochemical, fluorescent, colorimetric, and/or luminescent output and the methods can be performed in different modalities, including a solution-based or paper-based assay.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: April 23, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: I-Ming Hsing, Alan Fernando Rodriguez Serrano
  • Patent number: 11965100
    Abstract: Provided herein are aggregation-induced emission luminogens useful for imaging and/or detecting cancer cells and dynamically monitoring the viability of cancer cells and methods of use and preparation thereof.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: April 23, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Benzhong Tang, Ruoyao Zhang
  • Patent number: 11961302
    Abstract: A system for proctoring online exams includes a client-side computing system and a visual analytics system. The client-side computing system includes a camera configured to obtain video data corresponding to a user while taking an exam and one or more input devices configured to obtain interaction data, wherein the interaction data includes mouse movements of the user while taking the exam. The visual analytics system is configured to obtain the video data and the interaction data from the client-side computing system, analyze the exam data to detect abnormal behavior by the user based at least in part on mouse movement data, and generate one or more visualizations of the analyzed exam data to be used in determining whether or not the user has cheated during the exam.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: April 16, 2024
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Haotian Li, Min Xu, Huan Wei, Huamin Qu, Yong Wang
  • Patent number: 11945973
    Abstract: The ionic liquid-based coating is a coating for both porous and nonporous materials. As non-limiting examples, a porous substrate coated with the ionic liquid-based coating may be used to disinfect and remove microorganisms from air and water, to provide an antimicrobial surface for preventing microbial contamination, or to enhance filtration efficiency of the porous material for airborne and waterborne particulate matter without increasing flow resistance. As a further non-limiting example, a nonporous substrate coated with the ionic liquid-based coating may be used to form a surface capable of self-disinfection from microorganisms contacting surface. The ionic liquid-based coating includes at least one ionic liquid, an adhesive, and at least one additive, which may be a disinfectant, a viscosity modifier, a pH buffer, a fragrance, or combinations thereof.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: April 2, 2024
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: King Lun Yeung, Wei Han, Xizi Song, Joseph Kai Cho Kwan, Yutang Luo
  • Patent number: 11936107
    Abstract: The dipole-resonator resistive absorber is a metamaterial absorber operating in the microwave regime. A single unit of the dipole-resonator resistive absorber includes a first rectangular conductive ring having a pair of first resistors mounted thereon and in electrical communication therewith, and a plurality of parallel linear arrays of second rectangular conductive rings, where each of the second rectangular conductive rings has a pair of second resistors mounted thereon and in electrical communication therewith. The first rectangular conductive ring is mounted above the plurality of parallel linear arrays of the second rectangular conductive rings, and this structure is backed by an electrically conductive layer. The single unit dipole-resonator resistive absorber may be expanded into an arrayed structure, forming a polarization-independent dipole-resonator resistive absorber.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: March 19, 2024
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Ping Sheng, Sichao Qu, Yuxiao Hou
  • Patent number: 11929053
    Abstract: Sound absorbers using distributed absorption units each having an extended neck are provided. The absorption units can be, for example, Helmholtz resonators with extended neck (HRENs). The absorption units can be distributed in a lateral fashion, for example, in a checkerboard fashion with laterally, non-diagonally adjacent units having a different extended neck length and/or diameter. Each absorption unit can be, for example, a cylinder-structure core sandwiched between a back wall and a perforated plate.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: March 12, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Jingwen Guo, Xin Zhang, Yi Fang
  • Patent number: 11916156
    Abstract: A system comprising a biomimetic electrochemical eye (EC-EYE) and a computing device is provided. The EC-EYE comprises: an ionic liquid device; a nanowire (NW) device that comprises the plurality of NWs; and a connection device configured to provide a plurality of currents associated with the plurality of NWs to a computing device. The computing device comprises one or more processors and a display device. The one or more processors are configured to: receive the plurality of currents from the plurality of NWs via the connection device; determine a plurality of pixel characteristics associated with a plurality of pixels based on the plurality of currents from the plurality of NWs; generate an image comprising the plurality of pixels based on the plurality of pixel characteristics; and provide the image to a display device. The display device is configured to display the image.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: February 27, 2024
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhiyong Fan, Leilei Gu
  • Patent number: 11905703
    Abstract: A soft boundary structure is implemented using a resonator structure capable of receiving sound or vibration, establishing resonance coupled with received sound or vibration, and creating a reflection with a pi phase factor. A soft boundary is located on or closely adjacent the resonator structure. The soft boundary cooperates with the resonator structure to attenuate the sound or vibration.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: February 20, 2024
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Ping Sheng, Ho Yiu Mak, Xiaonan Zhang, Zhen Dong
  • Patent number: 11880114
    Abstract: Techniques for using ferroelectric liquid crystals Dammann grating (FLCDG) for light detection and ranging devices are disclosed. In LiDAR devices, accuracy, response time, and cost performance can be limited by some factors, such as laser pulse width, time resolution of a time-to-digital conversion chip, detector bandwidth, shot noise, and time error generated by electronic circuits. A FLCDG-based architecture can improve a LiDAR device, and provide for one-shot capturing due to the high switching speed at very low driving voltage provided by ferroelectric liquid crystals and the equal diffracting ability of Dammann grating.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: January 23, 2024
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhengnan Yuan, Abhishek Kumar Srivastava, Zhibo Sun, Hoi Sing Kwok
  • Patent number: 11874073
    Abstract: The present invention provides a radiative cooling structure that can be fabricated using solution-based processes and offer great IR-selectivity referring to low absorptivity within solar spectrum and high emissivity within the atmosphere transmission window (8-13 microns) for daytime radiative cooling. This structure includes a reflective layer, a ceramic IR-selectively emissive layer and a ceramic emission boosting layer, and the ceramic emission boosting layer is able to boost the overall emissivity of the radiative cooling structure within the atmosphere transmission windows and avoid infrared emission outside the atmosphere transmission window. The IR-selectivity contributes to larger temperature reduction, especially in high humidity area.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: January 16, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Baoling Huang, Chongjia Lin
  • Patent number: 11866424
    Abstract: Provided herein are aggregation-induced emission luminogens useful as photodynamic therapy and imaging agents, compositions including two or more aggregation-induced emission luminogens, pharmaceutical compositions comprising the same, and methods of use and preparation thereof.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: January 9, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Benzhong Tang, Wenhan Xu, Dong Wang
  • Patent number: 11871662
    Abstract: Provided herein are chiral compounds that exhibit circularly polarized photoluminescence and electroluminescence and electroluminescent devices and circularly polarized fluorescent probes comprising the same.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: January 9, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Benzhong Tang, Fengyan Song
  • Patent number: 11839998
    Abstract: Three-dimensional (3D) hierarchical morphologies widely exist in natural and biomimetic materials, which impart preferential functions including liquid and mass transport, energy conversion, and signal transmission for various applications. While notable progress has been made in the design and manufacturing of various hierarchical materials, the state-of-the-art approaches suffer from limited materials selection, high costs, as well as low processing throughput. Herein, by harnessing the configurable elastic crack engineering-controlled formation and configuration of cracks in elastic materials, an effect normally avoided in various industrial processes, the present invention provides a facile and powerful technique to enable the faithful transfer of arbitrary hierarchical structures with broad material compatibility and structural and functional integrity.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: December 12, 2023
    Assignees: Hong Kong Baptist University, The Hong Kong University of Science and Technology, City University of Hong Kong
    Inventors: Kangning Ren, Hongkai Wu, Zuankai Wang, Shuhuai Yao, Beng Ong, Wanbo Li, Zeyu Li, Han Sun, Chiu Wing Chan
  • Patent number: 11834620
    Abstract: Systems and methods related to centrifuge energy harvesting chambers (CEHCs) for gas production simulation are provided. Certain CEHCs may include a high-pressure chamber, high-pressure syringe pumps, cooling systems, an actuator and surcharge, backpressure control inside the wellbore, a heating element on the wellbore, water gas separation systems, and flow measurement systems. Certain CEHCs may also provide software operably connected to sensors and instrumentation, comprising a module to continuously, in real-time, periodically, or asynchronously, measure and monitor simulation variables.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: December 5, 2023
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Charles Wang Wai Ng, Sina Baghbanrezvan
  • Patent number: 11820762
    Abstract: The subject invention pertains to compositions and methods for treating neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis, epilepsy, stroke, alcohol withdrawal, progressive supranuclear palsy (PSP), Pick's disease (PiD), corticobasal degeneration (CBD), frontotemporal dementia or parkinsonism linked to chromosome 17 (FTDP-17). The methods of the subject invention further relate to methods of fermentation of bacterial cells and methods of tautomerization of the subject compounds.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: November 21, 2023
    Assignees: The Hong Kong University of Science and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
    Inventors: Pei-Yuan Qian, Aifang Cheng, Changdong Liu, Wenkang Ye, Guang Zhu
  • Publication number: 20230365441
    Abstract: A system and method for performing electrochemically-cycled oxidation on landfill leachate are provided for the removal of organic materials in landfill leachate which have an ultraviolet absorbance at 254 nm (UVA254), thus pre-treating the landfill leachate for co-treatment through dilution with municipal sewage. Electrochemical oxidation is performed on the landfill leachate in a first reactor chamber to produce hypochlorite (OCl?), followed by delayed application of ultraviolet radiation to produce hydroxyl radicals (OH•) and reactive chlorine species to break bonds in the organic materials. A portion of this partially-treated landfill leachate is then fed to a second reactor chamber for subsequent dichlorination through ultraviolet photolysis. An equivalent volume of fresh landfill leachate is fed into the first reactor chamber to begin the cycle again, allowing for continuous treatment of a source of landfill leachate.
    Type: Application
    Filed: May 9, 2023
    Publication date: November 16, 2023
    Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: YUGO SATO, GUANGHAO CHEN, YUEWEI LIU
  • Patent number: 11815457
    Abstract: Compounds including triphenylamine and luminol moieties exhibiting near-infrared chemiluminescence useful as reactive oxygen sensors, pharmaceutical compositions including the same, and methods of preparation and use thereof.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: November 14, 2023
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Benzhong Tang, Liang Luo, Chenchen Liu
  • Patent number: 11787817
    Abstract: The subject invention pertains to compositions comprising albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo. The subject invention further pertains to methods of treating a subject with HIV using albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo.
    Type: Grant
    Filed: June 1, 2022
    Date of Patent: October 17, 2023
    Assignees: The Hong Kong University of Science and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
    Inventors: Peiyuan Qian, Aifang Cheng, Changdong Liu, Wenkang Ye, Guang Zhu