Abstract: Systems and methods related to centrifuge energy harvesting chambers (CEHCs) for gas production simulation are provided. Certain CEHCs may include a high-pressure chamber, high-pressure syringe pumps, cooling systems, an actuator and surcharge, backpressure control inside the wellbore, a heating element on the wellbore, water gas separation systems, and flow measurement systems. Certain CEHCs may also provide software operably connected to sensors and instrumentation, comprising a module to continuously, in real-time, periodically, or asynchronously, measure and monitor simulation variables.
Type:
Grant
Filed:
November 16, 2021
Date of Patent:
December 5, 2023
Assignee:
The Hong Kong University of Science and Technology
Inventors:
Charles Wang Wai Ng, Sina Baghbanrezvan
Abstract: The subject invention pertains to compositions and methods for treating neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis, epilepsy, stroke, alcohol withdrawal, progressive supranuclear palsy (PSP), Pick's disease (PiD), corticobasal degeneration (CBD), frontotemporal dementia or parkinsonism linked to chromosome 17 (FTDP-17). The methods of the subject invention further relate to methods of fermentation of bacterial cells and methods of tautomerization of the subject compounds.
Type:
Grant
Filed:
September 15, 2021
Date of Patent:
November 21, 2023
Assignees:
The Hong Kong University of Science and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
Abstract: A system and method for performing electrochemically-cycled oxidation on landfill leachate are provided for the removal of organic materials in landfill leachate which have an ultraviolet absorbance at 254 nm (UVA254), thus pre-treating the landfill leachate for co-treatment through dilution with municipal sewage. Electrochemical oxidation is performed on the landfill leachate in a first reactor chamber to produce hypochlorite (OCl?), followed by delayed application of ultraviolet radiation to produce hydroxyl radicals (OH•) and reactive chlorine species to break bonds in the organic materials. A portion of this partially-treated landfill leachate is then fed to a second reactor chamber for subsequent dichlorination through ultraviolet photolysis. An equivalent volume of fresh landfill leachate is fed into the first reactor chamber to begin the cycle again, allowing for continuous treatment of a source of landfill leachate.
Type:
Application
Filed:
May 9, 2023
Publication date:
November 16, 2023
Applicant:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: Compounds including triphenylamine and luminol moieties exhibiting near-infrared chemiluminescence useful as reactive oxygen sensors, pharmaceutical compositions including the same, and methods of preparation and use thereof.
Type:
Grant
Filed:
March 1, 2021
Date of Patent:
November 14, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: The subject invention pertains to compositions comprising albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo. The subject invention further pertains to methods of treating a subject with HIV using albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo.
Type:
Grant
Filed:
June 1, 2022
Date of Patent:
October 17, 2023
Assignees:
The Hong Kong University of Science and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
Abstract: Various indirect feedback tuning apparatuses and methods for tuning photonic systems are enabled. For instance, a system can perform operations, such as: determining a temperature of an optical device, determining, based on the temperature of the optical device and a feedback model, a tuning input to stabilize an optical signal, and performing, based on the tuning input, feedback tuning, wherein the feedback tuning comprises thermal tuning and electrical tuning.
Type:
Grant
Filed:
December 8, 2020
Date of Patent:
October 10, 2023
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors:
Xuanqi Chen, Jiang Xu, Zhifei Wang, Yuxiang Fu
Abstract: Non-d0 rhenium(V) alkylidyne catalysts useful for catalyzing alkyne metathesis reactions, such as homo- and cross-metathesis of alkynes or diynes, ring closing metathesis and ring-opening metathesis, methods or use, and preparation thereof. The catalysts are stable to air and moisture and tolerate a variety of functional groups in substrates.
Type:
Grant
Filed:
July 5, 2022
Date of Patent:
October 10, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: Provided herein are multifunctional photoresponsive compositions that can undergo conversion from an aggregation-caused quenching (ACQ) state to an aggregation-induced emission (AIE) state and macroscopic actuation and systems comprising the same and methods of use thereof.
Type:
Grant
Filed:
July 28, 2020
Date of Patent:
September 26, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA replication and a method of screening for such agents by detecting the locations and functions of the MCM subunits, such as hMcm2 and hMcm6, in cells treated with candidate compounds.
Type:
Application
Filed:
April 17, 2023
Publication date:
September 21, 2023
Applicants:
The Hong Kong University Of Science And Technology, Hong Kong Baptist University, Macau University Of Science And Technology
Inventors:
Chun LIANG, Zhihong JIANG, Ziyi Wang, Zhiling Yu, Jingrong Wang, Liping Bai
Abstract: The subject invention pertains to the rapid amplification and real-time monitoring of nucleic acid sequences at a constant temperature. Specifically, fluorescent or electroactive-labeled loop probes and primers are designed to be specific to identified regions of a target nucleic acid sequences and subsequently amplify and permit the identification of the presence of the target sequence. In this method, a DNA polymerase with no 5? to 3? exonuclease activity is added to extend the primers and probes, while a nicking endonuclease is added to specifically identify the amplified nucleic acid product and cleave the label from the loop probe-extended DNA duplex.
Type:
Grant
Filed:
May 28, 2021
Date of Patent:
September 19, 2023
Assignee:
The Hong Kong University of Science and Technology
Inventors:
I-Ming Hsing, Xiao Lu, Henson Lim Lee Yu
Abstract: A fluorescent probe can include a compound exhibiting aggregation-induced emission (AIE). The probe can be used for selectively staining mitochondria and lipid droplets and detecting esterase activity. The probe includes an acetoxyl group which can be recognized by esterase in an esterase activity assay. As enzyme activity can reflect cell viability, the probe can be useful in cell viability detection. In addition, the probe includes a cationic moiety to target mitochondria and a lipophilic moiety that can target lipid droplets. A calculated log P value of the lipophilic moiety can be larger than 5.
Type:
Grant
Filed:
October 9, 2020
Date of Patent:
September 12, 2023
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A PAM-4 receiver with jitter compensation clock and data recovery is provided. The receiver includes a first-order delay-locked loop (DLL) which employs a bang-bang phase detector (BBPD) and a voltage-controlled delay line (VCDL) circuit supporting 40 MHz jitter tracking bandwidth and static phase skew elimination. A second-order wideband phase-locked loop (WBPLL) using the ¼-rate reference clock provides multi-phase clock generation with low input-to-output latency. To suppress the consequent jitter transfer, a jitter compensation circuit (JCC) acquires the jitter transfer amplitude and frequency information by detecting the DLL loop filter voltage (VLF(s)) signal, and generates an inverted loop filter voltage signal, denoted as VLFINV(s). The VLFINV(s) modulates a group of complementary VCDLs (C-VCDLs) to attenuate the jitter transfer on both recovered clock and data. With the provided receiver, a jitter compensation ratio up to 60% can be supported from DC to 4 MHz, with a ?3-dB corner frequency of 40 MHz.
Type:
Grant
Filed:
May 16, 2022
Date of Patent:
September 12, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: The present invention provides a signal fusion system that is a probabilistic system fusing an arbitrary combination of heterogeneous signals for determining the location of electronic devices. The system includes a signal sampling device for detecting one or more signals emitted by an electronic device to be located, including geolocation signals, WiFi signals, Bluetooth signals, 4G communication signals, 5G communication signals, geomagnetism signals, or inertial navigation system signals (INS). A likelihood processor cooperates with the signal sampling device to receive information about selected sampled signals, and creates a grid of reference points for an interested area in which the electronic device may be located. The likelihood processor independently computes, for each selected sampled signal, a location likelihood that is a probability of observing the sampled signal given that the electronic device is located at different reference points in the grid.
Type:
Grant
Filed:
June 11, 2021
Date of Patent:
August 29, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: The present disclosure relates to a method for growing III-V compound semiconductors on silicon-on-insulators. Starting from {111}-oriented Si seed surfaces between a buried oxide layer and a patterned mask layer, the III-V compound semiconductor is grown within lateral trenches by metal organic chemical vapor deposition such that the non-defective portion of the III-V compound semiconductor formed on the buried oxide layer is substantially free of crystalline defects and has high crystalline quality.
Type:
Grant
Filed:
February 26, 2020
Date of Patent:
August 29, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: A fluorescent compound for acid detection is strongly emissive in the solid state and can aggregate in the presence of an acid. As such, a fluorescent intensity emitted from the compound can be enhanced from an original intensity level in the presence of an acid. The fluorescent compound can emit an enhanced fluorescent intensity in the presence of an ultra-low acid concentration, for example, a concentration of at least about 10?20 M.
Type:
Grant
Filed:
January 13, 2020
Date of Patent:
August 29, 2023
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A gas sensor array comprises a plurality of metal decorated metal oxide film based on three-dimensional nanostructured templates, each including a porous anodized aluminum oxide (AAO) template and a plurality of metal decorated metal oxide films. The porous AAO substrate has a top surface with top gold electrodes, a bottom surface with bottom gold electrodes and a plurality of pores. Each pore has an interior wall and two openings located on the top surface and the bottom surface respectively for allowing air to enter into the pore. Each metal-decorated metal oxide film comprises a metal oxide film and metal decoration particles. The metal oxide film has an internal surface attaching on a respective interior wall and an external surf-ace being decorated with the metal particles. Each decoration metal is different to provide different sensitivities in response to an environmental gas.
Type:
Grant
Filed:
July 24, 2020
Date of Patent:
August 22, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: Provided herein are methods, kits, and devices related to genetic variations of neurological disorders. For example, methods, kits, and devices for using such genetic variations to assess susceptibility of developing Alzheimer's disease.
Type:
Grant
Filed:
October 30, 2017
Date of Patent:
August 15, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: An aerogel is formed by preparing metal-organic framework (MOF) aerogels by preparing a porous solid comprising a metal precursor for the metal-organic framework (MOF) aerogels, and transforming the metal precursor into the MOF by reacting the porous solid with organic ligands mixed with a solvent. The solvent is then removed by supercritical extraction and drying.
Type:
Grant
Filed:
December 27, 2019
Date of Patent:
August 15, 2023
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: Structures, devices and methods are provided for forming an interface protection layer (204) adjacent to a fully or partially recessed gate structure (202) of a group III nitride, a metal-insulator-semiconductor high-electron-mobility transistor (MIS-HEMT) device or a metal-insulator-semiconductor field-effect transistor (MIS-FET) device, and forming agate dielectric (114) disposed the interface protection layer (204).
Type:
Grant
Filed:
August 16, 2017
Date of Patent:
July 18, 2023
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A flexible display device that can conform to complex curved surfaces, and methods for manufacturing said display device, are disclosed herein. The display device utilizes a Miura-ori origami structure that, in a folded or at least partially folded configuration, is able to conform to complex curved surfaces. The Miura-ori structure involves folding a two-dimensional substrate in accordance with crease lines comprising a tessellation of parallelograms. Each cell of the tessellation pattern can include one or more luminous elements (LEDs, OLEDs, etc.) bonded to circuit elements embedded within the flexible substrate (e.g., Parylene-C).
Type:
Grant
Filed:
April 9, 2021
Date of Patent:
July 11, 2023
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY