Patents Assigned to The Hospital for Sick Children, HSC Research and Development Limited Partnership
  • Methods for determining risk of developing alzheimer's disease by detecting mutations in the presenilin 1 (PS-1) gene
    Patent number: 6194153
    Abstract: The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: February 27, 2001
    Assignees: The Hospital for Sick Children, HSC Research and Development Limited Partnership, The Governing Council of the University of Toronto
    Inventors: Peter H. St. George-Hyslop, Johanna M. Rommens, Paul E. Fraser
  • Genetic sequences and proteins related to alzheimer's disease
    Patent number: 5986054
    Abstract: The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
    Type: Grant
    Filed: January 26, 1996
    Date of Patent: November 16, 1999
    Assignees: The Hospital for Sick Children, HSC Research and Development Limited Partnership, The Governing Council of the University of Toronto
    Inventors: Peter H. St. George-Hyslop, Johanna M. Rommens, Paul E. Fraser