Patents Assigned to The Hospital for Special Surgery
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BIOLOGICAL MARKERS OF CHRONIC WOUND TISSUE AND METHODS OF USING FOR CRITERIA IN SURGICAL DEBRIDEMENT
Publication number: 20090203006Abstract: The present invention relates to methods for identifying tissue sites in a chronic wound that are suitable for debridement and whether debridement procedure has been successful using particular biological markers of the cells within the tissue sites of the chronic wounds.Type: ApplicationFiled: May 1, 2007Publication date: August 13, 2009Applicant: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special SurgeryInventors: Harold Brem, Marjana Tomic-Canic -
Publication number: 20090202638Abstract: This invention relates to BMP fusion genes, BMP fusion proteins, and methods for making BMP fusion genes and BMP fusion proteins. The invention further relates to methods for treatment using BMP fusion genes and BMP fusion proteins. Additionally, the invention relates to BMP fusion gene and BMP fusion protein pharmaceutical compositions.Type: ApplicationFiled: January 28, 2008Publication date: August 13, 2009Applicant: New York Society for the Ruptured and Crippled Maintaining The Hospital for Special SurgeryInventors: Chisa Hidaka, Wei Zhu
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Publication number: 20090204223Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.Type: ApplicationFiled: April 15, 2009Publication date: August 13, 2009Applicants: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery, Rhode Island HospitalInventors: Scott W. Wolfe, Joseph John Crisco, III
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Publication number: 20090177229Abstract: A surgical device for use in attaching a first member (e.g., soft-tissue) to a second member (e.g., a bone) includes a suture anchor that has a body having a first end; a pointed tip at an opposite second end; and a contoured outer surface. An anchor head that is coupled to the body at the first end has an opening to permit attachment of one or more suture to the body. The suture anchor also includes a reservoir formed in the body and being open at the first end thereof and closed at an opposite end. The reservoir is configured to store and release at least one of a drug, a therapeutic agent, a growth factor, or a combination thereof from a top surface of the anchor body into a site of an interface between the first and second members to promote healing or therebetween or limit post-operative pain.Type: ApplicationFiled: December 29, 2008Publication date: July 9, 2009Applicant: New York Society of the Ruptured and Crippled Maintaining the Hospital for Special SurgeryInventors: Lawrence V. Gulotta, Darrick Lo, Joseph David Lipman
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Publication number: 20090142769Abstract: The present invention relates to methods for identifying patients that will respond to treatment with anti-TNF-therapy, i.e., anti-TNF responder patients. In particular, the present invention relates to determining response to an inhibitor of tumor necrosis factor (TNF) in a patient with a chronic inflammatory disease by determining the activity of type I interferon in the patient. The invention further relates to quantification of type I interferon as a measure of predicting responsiveness to anti-TNF therapy in patients with a chronic inflammatory disease such as rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, juvenile chronic arthritis, lupus, Crohn's disease, as well as for cardiovascular disease.Type: ApplicationFiled: November 26, 2008Publication date: June 4, 2009Applicant: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special SurgeryInventors: Mary K. Crow, Kleio Mavragani
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Publication number: 20090068251Abstract: Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or promotion of healing of, wounds.Type: ApplicationFiled: March 12, 2008Publication date: March 12, 2009Applicant: Hospital for Special SurgeryInventors: Marjana TOMIC, Carl Peter Blobel, Asheesh Harsha
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Publication number: 20080274079Abstract: The present invention relates to methods and compositions that control, i.e., antagonize/inhibit or agonize/stimulate, de novo glucocorticoid production in the skin. Such methods and compositions can be used for the prevention and/or treatment of a variety of skin conditions, including inflammation, acute wounds, chronic non-healing wounds, keloid, fibrotic or hypertrophic scars, and epithelial-derived cancer.Type: ApplicationFiled: March 12, 2008Publication date: November 6, 2008Applicant: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special SurgeryInventors: Marjana Tomic-Canic, Harold Brem
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Publication number: 20080260829Abstract: This invention relates to BMP fusion genes, BMP fusion proteins. The invention further relates to methods for treatment using BMP fusion genes and BMP fusion proteins. Additionally, the invention relates to BMP fusion gene and BMP fusion protein pharmaceutical compositions.Type: ApplicationFiled: October 26, 2005Publication date: October 23, 2008Applicant: New YORK Society for the Ruptured and Crippled Maintaining The Hospital for Special SurgeryInventors: Chisa Hidaka, Wei Zhu
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Patent number: 7384652Abstract: The present invention provides a composition for osteoinduction, which comprises a complexed-acidic-phospholipid complex containing calcium, phospholipid, and inorganic phosphate combined with collagen in a composite form. The composition is effective to promote new bone formation upon introduction of the composition into various osseous defects.Type: GrantFiled: June 24, 2003Date of Patent: June 10, 2008Assignee: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special SurgeryInventors: Adele L. Boskey, Helen Tudor
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Publication number: 20080097615Abstract: A knee joint prosthesis includes a femoral component having an anterior side, a posterior side, a pair of laterally spaced condylar portions, and an intercondylar portion joining the condylar portions and including a recess. A cam surface is located adjacent the intercondylar recess on the anterior side of the femoral component and has a saddle shape that is defined by an at least substantially concave first radius of curvature and a convex third radius of curvature that is perpendicular to the concave first radius of curvature. The prosthesis also includes a tibial component including a platform having an upper surface that includes first and second laterally spaced concavities. Each concavity is adapted for receiving one condylar portion of the femoral component. The tibial component has a tibial post for reception in the intercondylar recess of the femoral component.Type: ApplicationFiled: September 24, 2007Publication date: April 24, 2008Applicant: The Hospital for Special SurgeryInventors: Joseph Lipman, Anna Rabinowicz
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Publication number: 20080051909Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.Type: ApplicationFiled: August 22, 2007Publication date: February 28, 2008Applicants: The Hospital for Special Surgery, Rhode Island HospitalInventors: Scott Wolfe, Joseph Crisco
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Publication number: 20070123466Abstract: Described are methods for treating, preventing, or reducing the risk of, miscarriages, especially recurrent miscarriages. The methods comprise administering to a female subject a therapeutic agent that modulates the activity or binding of components of the complement system, together with a pharmaceutically acceptable carrier. For example, the therapeutic agent can be a C3-convertase inhibitor, an antibody against C5, an antagonist of the C5a receptor, or an antibody against factor B or factor D. Screening methods for agents that can prevent or reduce the risk of miscarriages, especially recurrent miscarriages, are also described.Type: ApplicationFiled: May 13, 2004Publication date: May 31, 2007Applicants: New York Society for the Ruptured and Crippled Maintaining The Hospital for Special Surgery, The Regents of the Universuty of ColoradoInventors: Jane Salmon, Guillermina Girardi, V. Holers
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Publication number: 20070072935Abstract: The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some embodiments of the catalytic antioxidant compounds are derived from drugs with anti-inflammatory activity due to inhibition of cyclooxygenase enzymes.Type: ApplicationFiled: August 29, 2006Publication date: March 29, 2007Applicants: Florida Atlantic University, Hospital for Special SurgeryInventors: Herbert Weissbach, Nathan Brot
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Patent number: 7167742Abstract: A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.Type: GrantFiled: May 9, 2002Date of Patent: January 23, 2007Assignee: Hospital for Special SurgeryInventors: Nancy P. Camacho, Mathias P. G. Bostrom, Steve L. Bertha
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Patent number: 7129374Abstract: The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some embodiments of the catalytic antioxidant compounds are derived from drugs with anti-inflammatory activity due to inhibition of cyclooxygenase enzymes.Type: GrantFiled: November 26, 2003Date of Patent: October 31, 2006Assignees: Florida Atlantic University, Hospital for Special SurgeryInventors: Herbert Weissbach, Nathan Brot
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Publication number: 20060149266Abstract: The present invention relates to the field of orthopedics in addressing soft tissue to bone attachment. The embodiments of the present invention provide for a bioabsorbable inlay, a bioabsorbable inlay assembly, and a method to implant the bioabsorbable inlay between soft tissue and bone. Also provided is a means for facilitating soft tissue to bone attachment through the use of a bioabsorbable inlay, bounded with osteoconductive or osteoinductive materials, affixed at the interface of soft tissue to bone attachment sites. In an embodiment, the bioabsorbable inlay is formed into circular discs with holes for sutures to pass through and bounded with hydroxyapatite. The circular discs are then placed in communication between the soft tissue and bone at the appropriate site of attachment through the use of anchors and/or sutures. The bioabsorbable circular disc inlays are either overlaid or recessed into the bone.Type: ApplicationFiled: December 7, 2005Publication date: July 6, 2006Applicant: New York Society for the Ruptured and Crippled Maintaining The Hospital for Special SurgeryInventor: Frank Cordasco
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Publication number: 20060099633Abstract: The present invention provides methods for predicting the likelihood of development of systemic lupus erythematosus (SLE) in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding Fc?RIIB. The invention also provides isolated nucleic acids encoding Fc?RIIB polymorphisms, nucleic acid probes that hybridize to polymorphic positions and kits for the prediction of SLE status.Type: ApplicationFiled: December 16, 2005Publication date: May 11, 2006Applicant: New York Society for the Ruptured and Crippled Maintaining The Hospital for Special SurgeryInventor: Luminita Pricop
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Patent number: 7022476Abstract: The present invention provides methods for predicting the likelihood of development of systemic lupus erythematosus (SLE) in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding Fc?RIIB. The invention also provides isolated nucleic acids encoding Fc?RIIB polymorphisms, nucleic acid probes that hybridize to polymorphic positions and kits for the prediction of SLE status.Type: GrantFiled: February 26, 2002Date of Patent: April 4, 2006Assignee: New York Society for Ruptured and Crippled Maintaining the Hospital for Special SurgeryInventor: Luminita Pricop
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Publication number: 20050263159Abstract: The present invention is directed to a method of treating bone length discrepancies and angular deformities in a patient in need thereof, where the method involves radiofrequency ablation epiphysiodesis of a physeal plate. Specifically, the method treats long bone discrepancies with a minimally invasive procedure. The present invention is also directed to a method of inhibiting bone growth, where the method involves exposing a physeal growth plate to radiofrequency ablation epiphysiodesis.Type: ApplicationFiled: May 17, 2005Publication date: December 1, 2005Applicant: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special SurgeryInventor: Roger Widmann
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Patent number: 6939540Abstract: The present invention is directed to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding an angiogenic protein is administered to a cell in a region of a bone such that the nucleic acid is expressed to produce the angiogenic protein, whereby bone density or formation is enhanced within the region. Optionally, a nucleic acid encoding an osteogenic protein is administered to a cell within the same region such that the nucleic acid is expressed to produce the osteogenic protein. The method can be employed to produce a bone graft having a cell harboring an exogenous nucleic acid encoding an angiogenic protein and, optionally, a cell harboring a nucleic acid encoding an osteogenic protein. To facilitate the inventive method, the invention also pertains to a recombinant viral vector having a nucleic acid encoding an angiogenic protein and a nucleic acid encoding an osteogenic protein.Type: GrantFiled: July 31, 2000Date of Patent: September 6, 2005Assignees: Cornell Research Foundation, Inc., The Hospital for Special Surgery, GenVec, Inc.Inventors: Ronald G. Crystal, Chisa Hidaka, Oheneba Boachie-Adjei, Bernard A. Rawlins, Imre Kovesdi