Abstract: An algorithm for identification of microRNA (miRNA) targets within viral and cellular RNA is disclosed. Also disclosed are essential herpes virus genes whose transcripts contain one or more targets of miRNAs encoded by herpes viruses or by host cells as predicted by the algorithm, and the use of such targets, miRNAs and their derivatives for modulating viral replication and latency.
Type:
Application
Filed:
September 29, 2008
Publication date:
June 18, 2009
Applicants:
The Trustees of Princeton University, The Institute For Advanced Study - Louis Bamberger and Mrs. Felix Fuld Foundation
Inventors:
Jiri Vanicek, Eain Murphy, Harlan Robins, Arnold J. Levine, Thomas Shenk