Patents Assigned to The Institute for Ethnomedicine
  • Patent number: 11917986
    Abstract: L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates for treatment, amelioration and/or prevention of protein aggregation/tangles/plaques and diseases associated with protein aggregation/tangles/plaques. In particular, treatments and uses for L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates include Alzheimer's disease (AD), Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington disease (HD).
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: March 5, 2024
    Assignee: THE INSTITUTE FOR ETHNOMEDICINE
    Inventors: Paul Alan Cox, Sandra Anne Banack, Deborah C. Mash
  • Patent number: 11700840
    Abstract: L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates for treatment, amelioration and/or prevention of protein aggregation/tangles/plaques and diseases associated with protein aggregation/tangles/plaques. In particular, treatments and uses for L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates include Alzheimer's disease (AD), Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington disease (HD).
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: July 18, 2023
    Assignee: THE INSTITUTE FOR ETHNOMEDICINE
    Inventors: Kenneth Rodgers, Rachael Dunlop, Paul A. Cox
  • Patent number: 10048278
    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of ?-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: August 14, 2018
    Assignee: THE INSTITUTE FOR ETHNOMEDICINE
    Inventors: Paul Alan Cox, Sandra Banack, Susan Murch
  • Publication number: 20180027781
    Abstract: L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates for treatment, amelioration and/or prevention of protein aggregation/tangles/plaques and diseases associated with protein aggregation/tangles/plaques. In particular, treatments and uses for L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates include Alzheimer's disease (AD), Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington disease (HD).
    Type: Application
    Filed: October 6, 2017
    Publication date: February 1, 2018
    Applicant: THE INSTITUTE FOR ETHNOMEDICINE
    Inventors: Kenneth Rodgers, Rachael Dunlop, Paul A. Cox
  • Patent number: 8603753
    Abstract: An immunoassay for screening a sample to detect the presence of ?-N-methylamino-L-alanine (BMAA) is disclosed. Antibodies specific for BMAA are disclosed. Antibodies that bind to BMAA on immunoblots are disclosed. Immunoassays and kits to detect the presence of BMAA in a sample by contacting the sample with an antibody that binds to BMAA, and detecting the antibody bound to the sample, are disclosed. Immunoassays and kits for screening for the presence of BMAA in a subject by analyzing a tissue sample obtained from the subject to detect the present of BMAA in the tissue sample, where the presence of BMAA in the tissue sample indicates exposure of the subject to an environmental source of BMAA, are disclosed. Immunoassays and kits for detecting an environmental source of BMAA, by screening an environmental sample to detect the presence of BMAA in the sample, wherein the presence of a detectable amount of BMAA in the sample indicates the sample is an environmental source of BMAA, are disclosed.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: December 10, 2013
    Assignees: The Institute for Ethnomedicine, The University of Dundee
    Inventors: Paul Alan Cox, James S. Metcalf, Geoffrey A. Codd
  • Patent number: 8541184
    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of ?-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: September 24, 2013
    Assignee: The Institute for Ethnomedicine
    Inventors: Paul Alan Cox, Sandra Banack, Susan Murch
  • Publication number: 20130156846
    Abstract: L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates for treatment, amelioration and/or prevention of protein aggregation/tangles/plaques and diseases associated with protein aggregation/tangles/plaques. In particular, treatments and uses for L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates include Alzheimer's disease (AD), Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington disease (HD).
    Type: Application
    Filed: November 21, 2012
    Publication date: June 20, 2013
    Applicant: THE INSTITUTE FOR ETHNOMEDICINE
    Inventor: THE INSTITUTE FOR ETHNOMEDICINE
  • Publication number: 20110223624
    Abstract: An immunoassay for screening a sample to detect the presence of ?-N-methylamino-L-alanine (BMAA) is disclosed. Antibodies specific for BMAA are disclosed. Antibodies that bind to BMAA on immunoblots are disclosed. Immunoassays and kits to detect the presence of BMAA in a sample by contacting the sample with an antibody that binds to BMAA, and detecting the antibody bound to the sample, are disclosed. Immunoassays and kits for screening for the presence of BMAA in a subject by analyzing a tissue sample obtained from the subject to detect the present of BMAA in the tissue sample, where the presence of BMAA in the tissue sample indicates exposure of the subject to an environmental source of BMAA, are disclosed. Immunoassays and kits for detecting an environmental source of BMAA, by screening an environmental sample to detect the presence of BMAA in the sample, wherein the presence of a detectable amount of BMAA in the sample indicates the sample is an environmental source of BMAA, are disclosed.
    Type: Application
    Filed: July 2, 2009
    Publication date: September 15, 2011
    Applicant: THE INSTITUTE FOR ETHNOMEDICINE
    Inventors: Paul Alan Cox, James S. Metcalf, Geoffrey A. Codd
  • Publication number: 20110183424
    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of ?-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.
    Type: Application
    Filed: January 27, 2011
    Publication date: July 28, 2011
    Applicant: THE INSTITUTE FOR ETHNOMEDICINE
    Inventors: Paul A. Cox, Sandra A. Banack, Susan J. Murch
  • Patent number: 7901895
    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of ?-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: March 8, 2011
    Assignee: The Institute for Ethnomedicine
    Inventors: Paul A Cox, Sandra Banack, Susan Murch
  • Patent number: 7670783
    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of ?-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: March 2, 2010
    Assignee: The Institute for Ethnomedicine
    Inventors: Paul A Cox, Sandra Banack, Susan Murch
  • Publication number: 20070254315
    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of ?-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.
    Type: Application
    Filed: June 8, 2007
    Publication date: November 1, 2007
    Applicant: THE INSTITUTE FOR ETHNOMEDICINE
    Inventors: Paul Cox, Sandra Banack, Susan Murch
  • Patent number: 7256002
    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of ?-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: August 14, 2007
    Assignee: The Institute for Ethnomedicine
    Inventors: Paul A Cox, Sandra A Banack, Susan Murch