Abstract: Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds. Further, disclosed are combinations of an angiotensin converting enzyme inhibitor and a substituted indole acetic acid.
Type:
Application
Filed:
February 18, 2003
Publication date:
September 11, 2003
Applicant:
The Institutes for Pharmaceutical Discovery LLC., A Corporation of the State of Delaware
Abstract: Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
Type:
Application
Filed:
November 14, 2002
Publication date:
September 4, 2003
Applicant:
The Institutes for Pharmaceutical Discovery, Inc. A Corporation of the State of Delaware
Abstract: Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds.
Type:
Grant
Filed:
December 1, 1999
Date of Patent:
April 29, 2003
Assignee:
Institute for Pharmaceutical Discovery, L.L.C.
Abstract: Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis.
Type:
Application
Filed:
July 16, 2002
Publication date:
February 20, 2003
Applicant:
The Institutes of Pharmaceutical Discovery LLC.
Abstract: Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds. Further, disclosed are combinations of an angiotensin converting enzyme inhibitor and a substituted indole acetic acid.
Type:
Grant
Filed:
February 28, 2001
Date of Patent:
February 18, 2003
Assignee:
Institute for Pharmaceutical Discovery, LLC
Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
Type:
Application
Filed:
June 28, 2002
Publication date:
January 23, 2003
Applicant:
The Institute for Pharmaceutical Discovery LLC.
Inventors:
Michael Jones, David Gunn, John Jones, Michael Van Zandt
Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
Type:
Grant
Filed:
March 27, 2001
Date of Patent:
July 30, 2002
Assignee:
The Institutes for Pharmaceutical Discovery LLC
Inventors:
Michael Lee Jones, David Gunn, John Howard Jones, Michael C. Van Zandt
Abstract: Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis.
Type:
Grant
Filed:
June 23, 2000
Date of Patent:
July 16, 2002
Assignee:
The Institute for Pharmaceutical Discovery LLC
Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
Type:
Application
Filed:
March 27, 2001
Publication date:
August 23, 2001
Applicant:
The Institute for Pharmaceutical Discovery
Inventors:
Michael Jones, David Gunn, John Jones, Michael Van Zandt
Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
Type:
Grant
Filed:
March 31, 1999
Date of Patent:
April 10, 2001
Assignee:
The Institute for Pharmaceutical Discovery, Inc.
Inventors:
Michael Lee Jones, David Gunn, John Howard Jones, Michael C. Van Zandt