Abstract: The present invention provides a pharmaceutical tablet formulation of tenapanor that is chemically stable and soluble comprising greater than about 6% w/w of amorphous tenapanor in its bis-HCl form, an acidifying agent, an antioxidant, a disintegrant, a lubricant, a glidant, a filler, and an immediate release coating, wherein the total chloride content of the active ingredient is greater than 5.82% and the particle diameter distribution D50 is from about from about 18 ?m to about 22 ?m.

Abstract: This invention relates to pharmaceutical formulations for topical skin application comprising (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, or a pharmaceutically acceptable salt thereof, and use in the treatment of skin disorders.

Abstract: The present disclosure relates to chimeric small molecules, which find utility as modifiers of target substrates according to the formula A-L1-E-B or A-L1-E-L2-B, wherein A is a kinase binding moiety; B is a target binding moiety; L1 and L2 are each a linker; and E is an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to targets that are not the natural substrate of the kinase; accordingly, diseases or disorders may be treated or prevented with molecules of the present disclosure.

Abstract: A method for treating, preventing or reducing the likelihood of developing cognitive dysfunction that is associated with or induced by a cardiac condition (e.g., heart failure) by administering a therapeutically effective amount of a calcium channel stabilizer to a subject in need thereof.

Abstract: Disclosed herein are compositions comprising a long chain alcohol comprising octacosanol, hexacosanol, and/or tricontanol in an amount of at least 50% by weight based on total weight of the long chain alcohol; a cannabinoid; and a carrier. Also disclosed herein are compositions comprising a long chain alcohol; a cannabidiol; a vitamin; an ionophore; an amino acid; zinc; glutathione; and a carrier. Also disclosed are topical compositions and tinctures comprising any of the compositions disclosed herein. Also disclosed are methods of treating a disorder comprising administered any of the compositions disclosed herein.

Abstract: The present invention relates to lentiviral vectors encoding a progressive familial intrahepatic cholestasis-associated polypeptide. The present invention also relates to cells and pharmaceutical compositions comprising said lentiviral vectors and to uses of said lentiviral vectors in treating progressive familial intrahepatic cholestasis.

Abstract: The present invention relates to compositions comprising dried chicory root and pea cell wall fibers for reducing, preventing and/or treating dysentery in animals, poultry and humans. The invention also relates to the use of said compositions in feed and food.

Abstract: An indoor growing facility includes an enclosed structure defined by one or more first walls and a growing shell defining a grow zone positioned in the enclosed structure. The growing shell defined by one or more second walls. The indoor growing facility also includes at least one environmental control component positioned inside the enclosed structure and outside the growing shell.

Abstract: Low-altitude observation equipment includes a distance measurement device that generates a distance map and a position measurement device that measures a position of the low-altitude observation equipment. The low-altitude observation equipment moves in a region of a forest near a ground surface where there are no branches. A data acquisition unit acquires a low-altitude distance map generated by the distance measurement device and the position of the low-altitude observation equipment from the low-altitude observation equipment. A position specifying unit specifies a position of a tree, based on a distance from the low-altitude observation equipment to the tree specified based on the map, and on the position of the low-altitude observation equipment. An identification unit acquires identification information for identifying an individual of the tree based on the position of the tree.

Abstract: A mobile irrigation alignment system comprising a base mounted on a first span, a linkage system, and a control box. The linkage system includes a driven arm, drive arm, and control arm. The driven arm is pivotably connected to the base about a vertical axis. The drive arm is pivotably connected to the driven arm about a horizontal axis and includes a distal end configured to rest on an adjacent span. The control arm is linked to the driven arm. The control box determines lateral alignment between the spans based on the control arm as governed by the drive arm and driven arm. The drive arm is configured to retain an upright orientation relative to the driven arm regardless of torsional rotation between the spans so that the position of the control arm and hence the lateral alignment determination is not affected by the torsional rotation between the spans.

Abstract: A soybean cultivar designated 24450465 is disclosed. The invention relates to the seeds of soybean cultivar 24450465, to the plants of soybean cultivar 24450465, to the plant parts of soybean cultivar 24450465, and to methods for producing progeny of soybean cultivar 24450465. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 24450465. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 24450465, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 24450465 with another soybean cultivar.

Abstract: A soybean cultivar designated 23450022 is disclosed. The invention relates to the seeds of soybean cultivar 23450022, to the plants of soybean cultivar 23450022, to the plant parts of soybean cultivar 23450022, and to methods for producing progeny of soybean cultivar 23450022. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 23450022. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 23450022, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 23450022 with another soybean cultivar.

Abstract: A soybean cultivar designated 20430823 is disclosed. The invention relates to the seeds of soybean cultivar 20430823, to the plants of soybean cultivar 20430823, to the plant parts of soybean cultivar 20430823, and to methods for producing progeny of soybean cultivar 20430823. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 20430823. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 20430823, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 20430823 with another soybean cultivar.

Abstract: A soybean cultivar designated 22420517 is disclosed. The invention relates to the seeds of soybean cultivar 22420517, to the plants of soybean cultivar 22420517, to the plant parts of soybean cultivar 22420517, and to methods for producing progeny of soybean cultivar 22420517. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 22420517. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 22420517, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 22420517 with another soybean cultivar.

Abstract: A soybean cultivar designated 29440802 is disclosed. The invention relates to the seeds of soybean cultivar 29440802, to the plants of soybean cultivar 29440802, to the plant parts of soybean cultivar 29440802, and to methods for producing progeny of soybean cultivar 29440802. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 29440802. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 29440802, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 29440802 with another soybean cultivar.

Abstract: A soybean cultivar designated 23240202 is disclosed. The invention relates to the seeds of soybean cultivar 23240202, to the plants of soybean cultivar 23240202, to the plant parts of soybean cultivar 23240202, and to methods for producing progeny of soybean cultivar 23240202. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 23240202. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 23240202, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 23240202 with another soybean cultivar.

Abstract: A soybean cultivar designated 28491649 is disclosed. The invention relates to the seeds of soybean cultivar 28491649, to the plants of soybean cultivar 28491649, to the plant parts of soybean cultivar 28491649, and to methods for producing progeny of soybean cultivar 28491649. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 28491649. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 28491649, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 28491649 with another soybean cultivar.

Abstract: The present disclosure provides a bird feeder having a seed container, seed tray, cover and funnel to direct seeds onto the seed tray. The seed tray and funnel and engaged about a connection point, the connection point positioned below the base of the seed tray to improve the seed flow.

Abstract: A novel composition comprising a multiple-funnel trap, a light source, a solar panel, a battery, a photoswitch to control the light source, and a supporting structure can be effectively used to capture night-flying adult kissing bugs (Hemiptera: Reduviidae).

Abstract: A fungicidal composition containing a fungicidally effective amount of the compound of Formula I, (S)-1,1-bis(4-fluorophenyl) propan-2-yl (3-acetoxy-4-methoxypicolinoyl)-L-alaninate, and at least one fungicide selected from the group consisting of tebuconazole, prothioconazole, difenconazole, epoxiconazole, mefentrifluconazole, benzovindiflupyr, penthiopyrad, fluxapyroxad, bixafen, fluopyram, picoxystrobin, pyraclostrobin, azoxystrobin, mancozeb and chlorothalonil, provides synergistic control of selected fungi.