Patents Assigned to The Institute of Ophthalmology
  • Minimally invasive ab interno triple surgery for open-angle glaucoma
    Patent number: 11779490
    Abstract: A minimally invasive ab interno triple surgery for open-angle glaucoma comprises knotting and fixing a suture at the head end of an optical fiber catheter; performing miosis with carbachol, injecting the viscoelastic into the anterior chamber, making a lateral incision at the infratemporal corneal limbus, and placing the optical fiber catheter; cutting the Schlemm's canal on the nasal side of the anterior chamber, inserting an optical fiber into the incision on the Schlemm's canal, and cutting off the suture; injecting the viscoelastic to expand while retreating the microcatheter, and regularly injecting the viscoelastic; making a conjunctival flap on the eye and nose side, performing anterior chamber paracentesis, clamping out the suture using intraocular microforceps, and knotting in the sclera tunnel; and suturing the conjunctival flap using the suture, coating the eyes, and covering the eyes with gauze to finish the surgery.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: October 10, 2023
    Assignee: Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University
    Inventors: Ningli Wang, Qing Sang, Jin Wang, Dapeng Mu, Xueting Pei, Diya Yang
  • Transplantation of cells expressing markers for photoreceptor cells and retinal ganglion cells induced from Müller stem cells
    Patent number: 8691207
    Abstract: A method for the production of retinal cells, useful in transplantation therapy, comprises: (i) obtaining one or more mammalian adult Müller cells; and (ii) culturing the cells in the presence of an extracellular matrix protein and a growth factor to thereby induce dedifferentiation of the Müller cells into a progenitor phenotype.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: April 8, 2014
    Assignee: The Institute of Ophthalmology
    Inventors: Gloria Astrid Limb, Peng Tee Khaw
  • Muller cells de-differentiated to cells expressing markers of neural cell progenitors
    Patent number: 8173426
    Abstract: A method for the production of retinal cells, useful in transplantation therapy, comprises: (i) obtaining one or more mammalian adult Müller cells; and (ii) culturing the cells in the presence of an extracellular matrix protein and a growth factor to thereby induce dedifferentiation of the Müller cells into a progenitor phenotype.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: May 8, 2012
    Assignee: The Institute of Ophthalmology
    Inventors: Gloria Astrid Limb, Peng Tee Khaw
  • MULLER STEM CELLS
    Publication number: 20120100215
    Abstract: A method for the production of retinal cells, useful in transplantation therapy, comprises: (i) obtaining one or more mammalian adult Müller cells; and (ii) culturing the cells in the presence of an extracellular matrix protein and a growth factor to thereby induce dedifferentiation of the Müller cells into a progenitor phenotype.
    Type: Application
    Filed: December 30, 2011
    Publication date: April 26, 2012
    Applicant: THE INSTITUTE OF OPHTHALMOLOGY
    Inventors: GLORIA ASTRID LIMB, Peng Tee Khaw
  • Medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
    Patent number: 6759432
    Abstract: The use of an MMP inhibitor, especially a collagenase inhibitor, in the manufacture of a medicament for the treatment of a natural or artificial tissue comprising extracellular matrix components to inhibit contraction of the tissue and methods for the treatment of tissue comprising extracellular matrix components to inhibit contraction.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: July 6, 2004
    Assignees: University of Florida Research Foundation, Moorfields Eye Hospital National Health Service Trust, The Institute of Ophthalmology
    Inventors: Peng Tee Khaw, Gregory S. Schultz
  • Medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
    Patent number: 6093398
    Abstract: The use of an MMP inhibitor, especially a collagenase inhibitor, in the manufacture of a medicament for the treatment of a natural or artificial tissue comprising extracellular matrix components to inhibit contraction of the tissue and methods for the treatment of tissue comprising extracellular matrix components to inhibit contraction.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: July 25, 2000
    Assignees: University of Florida Research Found, Institute of Ophthalmology, Moorfields Eye Hospital NHS Trust
    Inventors: Peng Tee Khaw, Gregory S. Schultz