Abstract: Described embodiments include a system, method, and computer program product. A described system includes a receiver circuit that receives a first medical image. The first medical image includes a selected target region of interest of an individual patient's body part, and a landmark subsurface feature of the individual patient's body part having a first spatial relationship with the selected target region. The receiver circuit receives a second medical image that includes a candidate region of interest of the individual patient's body part, and a landmark feature of the individual's patient body part having a second spatial relationship with the candidate region. A feature matching circuit determines a correspondence between the candidate landmark subsurface feature and the associated landmark subsurface feature. A reporting circuit generates informational data indicating the second medical image includes at least a portion of the selected target region of interest.