Patents Assigned to THE JIKEI UNIVERSITY
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Publication number: 20220387507Abstract: The purpose of the present invention is to provide a novel medical application using pluripotent stem cells in regenerative medicine. The present invention provides a cell formulation and pharmaceutical composition that are for amelioration and therapy for frequent urination and bladder pain caused by the inflammation of the bladder and that contain SSEA-3 positive pluripotent stem cells isolated from cultured mesenchymal cells or a mesenchymal tissue of a living organism. The cell formulation according to the present invention is considered to be based on a mechanism in which, for example, Muse cells are administered against interstitial cystitis having the abovementioned disorders to be successfully engrafted into affected bladder tissue, whereby the disorders are ameliorated and treated.Type: ApplicationFiled: October 30, 2020Publication date: December 8, 2022Applicants: Life Science Institute, Inc., National University Corporation Tokai National Higher Education and Research System, THE JIKEI UNIVERSITY, TOHOKU UNIVERSITYInventors: Tokunori YAMAMOTO, Shinobu SHIMIZU, Akira FURUTA, Mari DEZAWA, Yasumasa KURODA
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Publication number: 20220378948Abstract: The present invention is intended to provide a peptide that selectively binds to a metal surface. Specifically, the present invention relates to a peptide consisting of an amino acid sequence as set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, or SEQ ID NO: 8, or a peptide substantially identical to the aforementioned peptide, and a method for detecting a metal surface of a medical device, using these peptides.Type: ApplicationFiled: August 14, 2020Publication date: December 1, 2022Applicant: The Jikei UniversityInventors: Yuji TERAMURA, Akifumi YOSHIHARA, Tomonobu KODAMA, Yuichi MURAYAMA
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Publication number: 20220304561Abstract: Provided is an overtube assembly including an overtube having an adjustable length. The overtube assembly has the overtube and a mouthpiece. The overtube has a plurality of recesses (e.g., grooves) on the outer circumference thereof. The mouthpiece has a locking portion (e.g., a protrusion or ridge) that is locked to the recesses. The mouthpiece can move between a locking position at which the locking portion engages with the recess and an unlocking position at which the locking portion does not engage with the recess.Type: ApplicationFiled: June 20, 2019Publication date: September 29, 2022Applicants: THE JIKEI UNIVERSITY, MURANAKA MEDICAL INSTRUMENTS CO. LTD., OKUMURA CO. LTD.Inventors: Kazuki SUMIYAMA, Shunsuke KAMBA, Shoji WAKITA, Hiroto TANAKA
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Patent number: 11261244Abstract: Disclosed is an isolated monoclonal antibody against a human Transforming Growth Factor-? (TGF-?) Latency Associated Protein (LAP) degradate, the isolated monoclonal antibody being capable of recognizing an integrin binding site in the human TGF-? LAP degradate.Type: GrantFiled: July 17, 2020Date of Patent: March 1, 2022Assignees: RIKEN, THE JIKEI UNIVERSITY, SYSMEX CORPORATIONInventors: Ikuyo Inoue, Soichi Kojima, Mikako Shirouzu, Chiemi Tsumagari, Takehisa Matsumoto, Takashi Saito, Toshitada Takemori, Tomokazu Matsuura, Takahiro Masaki, Masahiro Miura, Kozo Suto
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Patent number: 11147248Abstract: A method for producing a new deafness model animal and a new deafness model animal produced by the method, enabling research that can also be applied to clinical application to a human. The present invention provides a method for producing an acoustic trauma deafness model animal, the method including exposing a non-human primate animal to a sound having a frequency of 1 kHz to 32 kHz and a sound pressure level of 100 dB to 150 dB for 10 minutes to 360 minutes. In addition, the present invention provides an acoustic trauma deafness model animal provided by the method for producing an acoustic trauma deafness model animal.Type: GrantFiled: November 21, 2018Date of Patent: October 19, 2021Assignees: KEIO UNIVERSITY, THE JIKEI UNIVERSITY SCHOOL OF MEDICINEInventors: Masato Fujioka, Hirotaka James Okano, Hiromi Kojima, Sho Kurihara, Tomohiko Yoshida
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Publication number: 20210309761Abstract: For human liver cancer cell lines which have been found to extracellularly release PKC?, an analysis of neutralization of the action of PKC? was carried out using a monoclonal antibody against PKC?. As a result, it was found that anti-PKC? antibody or an antigen-binding fragment thereof has a cell growth-inhibiting effect on the liver cancer cell lines.Type: ApplicationFiled: November 16, 2020Publication date: October 7, 2021Applicant: THE JIKEI UNIVERSITYInventors: Kohji YAMADA, Ryusuke KIZAWA, Kiyotsugu YOSHIDA
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Publication number: 20210100884Abstract: A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.Type: ApplicationFiled: December 15, 2020Publication date: April 8, 2021Applicants: JAPANESE FOUNDATION FOR CANCER RESEARCH, THE JIKEI UNIVERSITYInventors: Masaki ITO, Kiyotaka SHIBA
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Publication number: 20210100885Abstract: A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.Type: ApplicationFiled: December 15, 2020Publication date: April 8, 2021Applicants: JAPANESE FOUNDATION FOR CANCER RESEARCH, THE JIKEI UNIVERSITYInventors: Masaki ITO, Kiyotaka SHIBA
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Publication number: 20210085807Abstract: The present invention is intended to provide a peptide that selectively binds to a metal surface. The present invention relates to a peptide consisting of an amino acid sequence as set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, or SEQ ID NO: 21, or a peptide substantially identical to the aforementioned peptide, and a method for detecting a metal surface of a medical device, using these peptides.Type: ApplicationFiled: January 16, 2019Publication date: March 25, 2021Applicants: The University of Tokyo, The Jikei University School of MedicineInventors: Yuji Teramura, Tomoyuki Azuma, Akifumi Yoshihara, Tomonobu Kodama, Yuichi Murayama
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Patent number: 10898555Abstract: A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.Type: GrantFiled: June 30, 2014Date of Patent: January 26, 2021Assignees: JAPANESE FOUNDATION FOR CANCER RESEARCH, THE JIKEI UNIVERSITYInventors: Masaki Ito, Kiyotaka Shiba
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Publication number: 20210017265Abstract: Disclosed is an isolated monoclonal antibody against a human TGF-? LAP degradate, the isolated monoclonal being capable of recognizing an integrin binding site in the human TGF-? LAP degradate.Type: ApplicationFiled: July 17, 2020Publication date: January 21, 2021Applicants: RIKEN, THE JIKEI UNIVERSITY, SYSMEX CORPORATIONInventors: Ikuyo INOUE, Soichi Kojima, Mikako Shirouzu, Chiemi Tsumagari, Takehisa Matsumoto, Takashi Saito, Toshitada Takemori, Tomokazu Matsuura, Takahiro Masaki, Masahiro Miura, Kozo Suto
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Patent number: 10368980Abstract: The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cells in the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80° C., wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.Type: GrantFiled: April 14, 2016Date of Patent: August 6, 2019Assignees: Tokyo Women's Medical University, The Jikei University, CellSeed Inc.Inventors: Takanori Hama, Hiromi Kojima, Hiroshi Moriyama, Masayuki Yamato, Teruo Okano
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Patent number: 10233099Abstract: Disclosed herein is a radioactive cesium decontaminator, a method of producing a radioactive cesium decontaminator, and a method of removing radioactive cesium using the decontaminator. The radioactive cesium decontaminator is formed by agglomeration of primary particles. The primary particles have a magnetic particle as a core portion, a coating layer made of an organic material coating the magnetic particle, and a capturing compound made of ferrocyanide material formed on the coating layer. A cumulative diameter D50 of the decontaminator is in a range of from 2.0 ?m to 50 ?m, and a value of a cumulative diameter distribution (D90?D10)/D50 is less than 6. The decontaminator is made by adding a ferrocyanide aqueous solution and an aqueous solution containing at least one transition metal into a suspension liquid containing a precursor formed by magnetic particles coated with organic monomer or polymer while applying a strong shear force.Type: GrantFiled: September 10, 2013Date of Patent: March 19, 2019Assignees: THE JIKEI UNIVERSITY, DOWA HOLDINGS CO., LTD.Inventors: Yoshihisa Namiki, Toshihiko Ueyama, Takayuki Yoshida, Ryoei Watanabe
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Patent number: 9758766Abstract: The present invention provides an artificial kidney precursor containing a non-human mammalian metanephros separated out from a living body, wherein the metanephros has been subjected to freezing and thawing treatments outside a living body, and contains mammalian mesenchymal stem cells transferred outside a living body, and a method of production thereof.Type: GrantFiled: December 9, 2014Date of Patent: September 12, 2017Assignees: OTSUKA PHARMACEUTICAL FACTORY, INC., JICHI MEDICAL UNIVERSITY, THE JIKEI UNIVERSITY, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Eiji Kobayashi, Takashi Yokoo, Koutaro Kai
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Patent number: 9679670Abstract: There is provided an aggregate of radioactive material removing particles in which two or more radioactive material removing particles having magnetic particles and a radioactive material adsorption component are assembled, wherein a pore volume in the aggregate is 0.5 mL/g or more and 5.0 mL/g or less, and the pore volume means a cumulative value obtained by a mercury press-in method.Type: GrantFiled: May 19, 2014Date of Patent: June 13, 2017Assignees: THE JIKEI UNIVERSITY, DOWA HOLDINGS CO., LTD.Inventors: Yoshihisa Namiki, Toshihiko Ueyama, Takayuki Yoshida
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Publication number: 20160220356Abstract: The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cells in the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80° C., wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.Type: ApplicationFiled: April 14, 2016Publication date: August 4, 2016Applicants: Tokyo Women's Medical University, The Jikei University, CellSeed Inc.Inventors: Takanori Hama, Hiromi Kojima, Hiroshi Moriyama, Masayuki Yamato, Teruo Okano
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Publication number: 20160166665Abstract: A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.Type: ApplicationFiled: June 30, 2014Publication date: June 16, 2016Applicants: JAPANESE FOUNDATION FOR CANCER RESEARCH, THE JIKEI UNIVERSITYInventors: Masaki ITO, Kiyotaka SHIBA
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Publication number: 20150239758Abstract: There is provided a method of producing a radioactive cesium decontaminator, including: suspending magnetic particles in a solvent, and coating each magnetic particle with organic monomer or polymer, to thereby form a precursor; adding a ferrocyanide aqueous solution and an aqueous solution containing at least one kind of transition metal into a suspension liquid containing the precursor after coating while applying a strong shear force, to thereby generate a radioactive cesium decontaminator; and removing water content from a slurry containing the obtained radioactive cesium decontaminator.Type: ApplicationFiled: September 10, 2013Publication date: August 27, 2015Applicants: THE JIKEI UNIVERSITY, DOWA HOLDING CO., LTD.Inventors: Yoshihisa Namiki, Toshihiko Ueyama, Takayuki Yoshida, Ryoei Watanabe
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Patent number: 8740797Abstract: An ultrasonic therapeutic apparatus according to the present invention being provided with: an ultrasonic probe (102) provided with a group of ultrasonic transducers for diagnosis use and a group of ultrasonic transducers for therapeutic use of which at least apart of ultrasonic beam irradiation surfaces are arranged so as to overlap each other, a tomographic image producing means (8) that produces a tomographic image containing a diseased portion of a subject from reflection echoes received by the group of ultrasonic transducers for diagnosis use, a display means (10) that displays the tomographic image containing the diseased portion of the subject produced by the tomographic image producing means (8), a setting means (103) that sets an irradiation path of the therapeutic ultrasonic waves on the tomographic image containing the diseased portion of the subject displayed by the display means (10) and a control means (104) that produces irradiation path information corresponding to the irradiation path of theType: GrantFiled: June 22, 2006Date of Patent: June 3, 2014Assignee: The Jikei UniversityInventors: Makoto Ogihara, Jun Kubota, Akira Sasaki, Hiroshi Furuhata, Toshihiro Ishibashi
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Publication number: 20140042068Abstract: Provided is a radioactive substance collecting system and a radioactive substance collecting method which are capable of collecting radioactive substances with high efficiency. The radioactive substance collecting system according to the present invention removes radioactive substances (radioactive cesium 21) contained in a liquid (radioactive substances-contaminated water 20) and includes, as means for removing radioactive substances from the liquid, a radioactive substance trapping composite 1 including at least a magnetic particle 10 and a radioactive substance trapping compound 11 that traps radioactive substances, and magnetic accumulation means 30 for accumulating the radioactive substance trapping composite 1.Type: ApplicationFiled: March 13, 2012Publication date: February 13, 2014Applicant: The Jikei UniversityInventor: Yoshihisa Namiki