Patents Assigned to The Johns Hopkin University
  • System for conditioning of engineered microtissues
    Patent number: 10590376
    Abstract: A system and method for conditioning a tissue are provided. The system includes a substrate, a plurality of microwells formed in the substrate, and a microsphere associated with each of the plurality of microwells. The system also includes a pair of flexible pillars within each of the plurality of microwells. Each flexible pillar includes a first end bonded to a respective microwell and at least one flexible pillar has a second end bonded to the microsphere. The flexible pillars are configured to deflect when exposed to a magnetic field to controllably stretch microtissue spanning the flexible pillars.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: March 17, 2020
    Assignee: The Johns Hopkins University
    Inventors: Daniel H. Reich, Fan Xu, Ruogang Zhao, Alan S. Liu, Tristin Metz, Yu Shi
  • Dark field endoscopic microscope
    Patent number: 10582841
    Abstract: A dark field endoscopic microscope includes an illumination system, an objective lens unit arranged in an optical path of the illumination system, an optical fiber bundle optically coupled to the objective lens unit, and an observation system arranged in an optical return path from the optical fiber bundle. The illumination system provides oblique off-axial illumination while axial rays are at least attenuated.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: March 10, 2020
    Assignee: The Johns Hopkins University
    Inventors: Jin U. Kang, Xuan Liu
  • Optimizing diagnostics for galactofuranose containing antigens
    Patent number: 10585098
    Abstract: Disclosed herein are methods of detecting microbial infection in mammalian subjects comprising treatment of a sample and detection of galactofuranose (galF)-containing antigenic components utilizing monoclonal antibodies. The methods disclosed provide for pretreatment of biological samples, such as urine samples, to maximize detection of galF antigens and improvement of sensitivity of galF antigen detection assays. The methods include minimizing intelectin-1 binding to galF antigens and improvement of monoclonal antibody binding. The detection methods are useful for identifying the presence of microbial antigens related to bacterial, fungal, and parasitic pathogens, including Streptococcus pneumoniae, Aspergillus species, Fusarium species, Coccidioides species, Cryptococcus species, Histoplasma species, and Leishmania species.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: March 10, 2020
    Assignee: The Johns Hopkins University
    Inventor: Kieren A. Marr
  • N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors and uses thereof
    Patent number: 10583141
    Abstract: N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors are disclosed. Pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions also are disclosed.
    Type: Grant
    Filed: June 25, 2016
    Date of Patent: March 10, 2020
    Assignee: The Johns Hopkins University
    Inventors: John P. Toscano, Saghar Nourian
  • Targeting liver nuclear receptors as a treatment for wilson disease
    Patent number: 10583102
    Abstract: The present invention relates to the field of Wilson Disease. More specifically, the present invention provides methods and compositions useful for treating Wilson Disease by targeting liver nuclear receptors. In a specific embodiment, a method for treating Wilson Disease in a subject comprises the step of administering to the subject an effective amount of a liver X receptor (LXR) agonist.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: March 10, 2020
    Assignee: The Johns Hopkins University
    Inventors: Svetlana Lutsenko, James Hamilton
  • CRISPR/CAS9-BASED COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20200069818
    Abstract: Described herein are methods for preventing, inhibiting, or treating cancer in a subject. Also provided herein are methods of altering expression of one or more gene products in a cell, such as a cancer cell. Such methods may comprise utilizing a modified nuclease system, such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated (Cas) 9 (CRISPR-Cas9) comprising a bidirectional HI promoter and gRNAs directed to oncogenes (rAAV-Onco-CRISPR) or tumor suppressor genes (rAAV-TSG) packaged in a compact adeno-associated virus (AAV) particle. Such methods may comprise co-administering or concurrently providing a recombinant adeno-associated virus-packaging adenovirus (Ad-rAAVpack) with the nuclease system.
    Type: Application
    Filed: July 5, 2017
    Publication date: March 5, 2020
    Applicant: The Johns Hopkins University
    Inventors: Vinod JASKULA-RANGA, Donald ZACK, Fred BUNZ
  • Medical sensors for clinical and training applications
    Patent number: 10580324
    Abstract: The present invention is directed to systems for interfacing between sensors and sensor simulators and clinical monitors and devices. The present invention is used to incorporate sensors and sensor simulators into training and clinical demonstrations. A system in accordance with the present invention includes a hardware component configured to transmit an output signal associated with a typical clinical sensor such as sensors for end-tidal CO2, pulse oximetry, temperature, blood pressure, near-infrared spectroscopy (NIRS) sensors, and CPR sensors to a clinical monitor or similar device. The system of the present invention also provides a software component to produce and transmit or to receive and make use of the simulated or actual sensor; the system also provides a hardware component to interface the software component to the clinical monitor, defibrillator, and/or sensor.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: March 3, 2020
    Assignee: THE JOHN HOPKINS UNIVERSITY
    Inventors: Jordan Duval-Arnould, Julie Campbell, Elizabeth Hunt
  • Automatable method for directing catheter movement to target arrhythmia ablation using the cardiac activation sequence
    Patent number: 10575739
    Abstract: The present invention is directed to an automatable method for directing electrophysiology catheter movement toward the site of arrhythmia origin using the cardiac activation sequence measured during arrhythmia and during pacing. The purpose of this method is to improve the speed and accuracy of localizing the site of arrhythmia origin for the purpose of targeting therapeutic ablation of the arrhythmia.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: March 3, 2020
    Assignee: The Johns Hopkins University
    Inventor: Aravindan Kolandaivelu
  • Electromagnetic tracking system and methods of using same
    Patent number: 10575797
    Abstract: An electromagnetic tracking system including a patient support element and an electromagnetic field generator. The patient support element is superposed relative to the electromagnetic field generator, and the electromagnetic field generator is selectively moveable relative to the patient support element.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: March 3, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jeffrey H. Siewerdsen, Jongheun Yoo
  • Methods for monitoring C9ORF72 expression
    Patent number: 10577604
    Abstract: Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: March 3, 2020
    Assignees: Ionis Pharmaceuticals, Inc., The Johns Hopkins University
    Inventors: C. Frank Bennett, Susan M. Freier, Jeffrey D. Rothstein, Christopher Donnelly, Rita G. Sattler
  • Compositions and methods for treating kabuki syndrome and related disorders
    Patent number: 10568854
    Abstract: A method is provided for treating a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) in a subject in need thereof. In particular, the method comprises administering to the subject a ketogenic composition in an amount sufficient to produce a physiologically acceptable ketosis in the subject. A method for selecting a subject for treatment of a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) is also provided. Ketogenic compositions and kits useful for practicing the methods are also provided.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: February 25, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hans Tomas Bjornsson, Harry Dietz, Joel Benjamin
  • Method and apparatus for tamper detection along enclosed or buried conduction media using fluorescent optical fiber
    Patent number: 10571311
    Abstract: A method of detecting tampering with a conveyance medium may include determining a baseline brightness level detected at opposing ends of an optical fiber segment disposed proximate to the conveyance medium, determining whether a change in brightness above a threshold level occurs, and providing an output indicating that a breach in continuity of a shielding material that shields both the conveyance medium and the optical fiber segment from exposure to ambient light has occurred in response to the change in brightness being above the threshold level.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: February 25, 2020
    Assignee: The Johns Hopkins University
    Inventors: Eric R. Skrabacz, Paul R. Schuster
  • Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
    Patent number: 10568975
    Abstract: Surface conjugated diamagnetic Chemical Exchange Saturation Transfer (diaCEST) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based MRI contrast agents that are often toxic and therefore not biocompatible. The carriers described herein can provide simultaneous monitoring of multiple particle types labeled with ‘multicolor’ diaCEST contrast agents. In some embodiments, the carriers are micro- and/or nanoparticles. In other embodiments, the carriers are liposomes. In some embodiments, the particles and/or liposomes are mucus penetrating. In other embodiments, the particles and/or liposomes are not mucus penetrating.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: February 25, 2020
    Assignee: The Johns Hopkins University
    Inventors: Tao Yu, Himatkumar Patel, Kannie M. Y. Chan, Nikita Oskolkov, Michael McMahon, Justin Hanes
  • Methods and compositions for treating metabolic reprogramming disorders
    Patent number: 10568868
    Abstract: The disclosure provides methods of treating a condition, disease, or disorder in a subject that involves metabolically reprogrammed cells whose activation, function, growth, proliferation, or survival depends on increased activity of at least one metabolic pathway selected from the group consisting of glutamine metabolism, glycolysis, and fatty acid synthesis, comprising administering to the subject a compound having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2?, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON).
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: February 25, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Barbara Slusher, Jonathan Powell
  • Cell impregnated sleeve for paracrine and other factor production
    Patent number: 10561830
    Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 18, 2020
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Zhiyong Xia, Virginia E. Bogdan, Jeffrey A. Brinker, Gary Gerstenblith, Peter V. Johnston, Steven P. Schulman, Gordon Tomaselli, Robert G. Weiss
  • Image-guided embryo transfer for in vitro fertilization
    Patent number: 10561443
    Abstract: A method for performing image-guided embryo transfer for in vitro fertilization includes performing a pre-operative magnetic resonance imaging (MRI) scan of a subjects pelvic region to yield a first MRI image dataset. A computer applies a segmentation routine to the first MRI image dataset to yield segment data which is then used by the computer to create an anatomical model of the subjects pelvic region. The computer determines an optimal implant location based on the anatomical model and creates a three-dimensional rendering of the optimal implant location based on the first MRI image dataset.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: February 18, 2020
    Assignees: Siemens Healthcare GmbH, The Johns Hopkins University
    Inventors: Wesley David Gilson, Jan Fritz
  • Method and apparatus for remote malware monitoring
    Patent number: 10567398
    Abstract: A method executable via operation of configured processing circuitry to identify applications by remote monitoring may include initiating remote communication with a target device through an access point, the access point providing network access to the target device, providing a series of ping messages to the target device via the access point to determine a delay signature of an application running on the target device, comparing the delay signature of the application to a plurality of malware traffic signatures stored in a malware traffic signature library, and determining a matching score between the delay signature of the application and at least some of the malware traffic signatures.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: February 18, 2020
    Assignee: The Johns Hopkins University
    Inventor: Lanier A. Watkins
  • High power transmission using multi-tone signals
    Patent number: 10567014
    Abstract: Various apparatuses and methods for high power transmission using multi-tone signals are provided. One example method includes providing, by signal processing circuitry having a plurality of processor outputs, a data stream for each processor output, and modulating each data stream with a carrier tone to generate modulated data streams as incoherent signals. The example method may also include forming a multi-tone signal based on the modulated data streams, and outputting the multi-tone signal on each of the processor outputs for provision, after being amplified by respective amplifiers, to a power combiner for coherent combination of the multi-tone signals by the power combiner and wireless transmission via an antenna.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: February 18, 2020
    Assignee: The Johns Hopkins University
    Inventor: Kenaz S. Wong
  • Emetine compounds for treatment and prevention of flavivirus infection
    Patent number: 10555942
    Abstract: The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: February 11, 2020
    Assignees: Florida State University Research Foundation, Inc., The Johns Hopkins University, The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Hengli Tang, Emily M. Lee, Anil Mathew Tharappel, Hongjun Song, Guo-Li Ming, Wei Zheng, Miao Xu, Shu Yang, Ruili Huang, Wenwei Huang, Khalida Shamim, Hao Li
  • Lipid-based drug carriers for rapid penetration through mucus linings
    Patent number: 10556017
    Abstract: Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. The nanoparticle have an average diameter of about 100 nm to about 300 nm, preferably from about 100 nm to about 250 nm, more preferably from about 100 nm to about 200 nm. The particles are mobile in mucus. The liposomes can further contain one or more therapeutic, prophylactic, and/or diagnostic agent to be delivered to a mucosal surface, such as the CV tract, the colon, the nose, the lungs, and/or the eyes. The liposomes can further contain one or more CEST agents to allow real time imaging of the particles in a live animal. The particles may also further contain an imaging agent, such as a fluorescent label.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: February 11, 2020
    Assignee: The Johns Hopkins University
    Inventors: Justin Hanes, Kannie Wai Yan Chan, Michael T. McMahon, Ming Yang, Tao Yu