Patents Assigned to The jUnited States of America as represented by Secretary, Dept. of Health and Human Service
  • MULTIFUNCTIONAL NANOPARTICLES AND COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20100092384
    Abstract: Provided is a multifunctional particle comprising: (a) an inner metallic core, (b) a biocompatible shell comprising an optical contrast agent embedded therein, and (c) a targeting biomolecule conjugated to the biocompatible shell through a multidentate ligand, wherein the multidentate ligand is chelated to an imaging agent. Also provided are compositions comprising the multifunctional particle and methods of using the multifunctional particle, including a method of diagnostic imaging and a method of treatment.
    Type: Application
    Filed: March 17, 2008
    Publication date: April 15, 2010
    Applicants: The jUnited States of America as represented by Secretary, Dept. of Health and Human Service, University of Oxford
    Inventors: Ambika Bumb, Martin W. Brechbiel, Peter Choyke, Lars Fugger, Peter James Dobson