Patents Assigned to The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Science
  • 15-oxospiramilactone derivatives, preparation method and uses thereof
    Patent number: 10112918
    Abstract: The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the compound as pharmaceutically active ingredient, a method for preparing the same, and use thereof in manufacture of an anti-tumor agent. The derivative of 15-oxospiramilactone of the invention have an activity against multiple tumor cell lines, and the anti-tumor activity is positively correlated to an activity inhibiting the Wnt signaling pathway.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: October 30, 2018
    Assignees: Kunming Institute of Botany, The Chinese Academy of Sciences, The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Science, Shanghai Institutes of Biological Sciences, CAS, Institute of Zoology, Chinese Academy of Sciences
    Inventors: Xiaojiang Hao, Chen Yan, Haiyang Liu, Lin Li, Xiaoli He, Quan Chen
  • Phenylalanine dipeptide derivatives, compositions and use thereof
    Patent number: 9023809
    Abstract: Disclosed are a compound of formula I, stereoisomers, pharmaceutically acceptable salts or hydrates thereof, a pharmaceutical composition comprising the same, a process for preparing the same and use thereof. The compound may also be used to prepare a medicament to treat viral infections, especially to prepare a medicament to treat hepatitis B virus and human immunodeficiency virus with little toxic side effects.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: May 5, 2015
    Assignees: The Key Laboratory of Chemistry For Natural Products of Guizhou Province and Chinese Academy of Sciences, Tianjin Institute of Pharmaceutical Research, 302 Hospital of PLA, China
    Inventors: Guangyi Liang, Bixue Xu, Changxiao Liu, Zhengming Huang, Peixue Cao, Zegui Cai, Yuming Liu