Patents Assigned to The Leland Stanford Junior University
  • Methods for manipulating phagocytosis mediated by CD47
    Patent number: 9493575
    Abstract: Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: November 15, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Siddhartha Jaiswal, Irving L. Weissman, Ravindra Majeti, Mark P. Chao
  • Modulation of synaptic maintenance
    Patent number: 9493555
    Abstract: C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: November 15, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ben A. Barres, Beth A. Stevens
  • MODULATION OF SYNAPTIC MAINTENANCE
    Publication number: 20160326534
    Abstract: C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including treating and preventing neurodegenerative diseases such as Alzheimer's disease.
    Type: Application
    Filed: July 28, 2016
    Publication date: November 10, 2016
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ben A. Barres, Alexander H. Stephen, Beth A. Stevens
  • Compositions and methods to treat latent viral infections
    Patent number: 9487802
    Abstract: Viral infection is a persistent cause of human disease. Guided nuclease systems target the genomes of viral infections, rendering the viruses incapacitated.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: November 8, 2016
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Stephen R. Quake, Jianbin Wang
  • Spectral imaging system and method
    Patent number: 9488739
    Abstract: Spectral x-ray imaging using a photon counting x-ray detector (PCXD) transmits a broad spectrum x-ray beam through an object, detects the transmitted x-ray beam with the PCXD and processes the detected signals to determine material characteristics of the object using both the detected signals as a function of detector layer and the detected signals as a function of the particular energy band. Each detector layer of the multiple detector layers produces at least two signals, each signal representing a detected x-ray intensity in a particular energy band, and the depth information contained in the separate read-out channels.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: November 8, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Norbert J. Pelc
  • Self-healing composites and applications thereof
    Patent number: 9490045
    Abstract: A battery electrode includes an electrochemically active material and a binder covering the electrochemically active material. The binder includes a self-healing polymer and conductive additives dispersed in the self-healing polymer to provide an electrical pathway across at least a portion of the binder.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: November 8, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chee Keong Tee, Chao Wang, Hui Wu, Yi Cui, Zhenan Bao
  • Trajectory-based deep-brain stereotactic transcranial magnetic stimulation
    Patent number: 9486639
    Abstract: The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: November 8, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David J. Mishelevich, M. Bret Schneider
  • Model-less control for flexible manipulators
    Patent number: 9488971
    Abstract: A control method includes empirically constructing for a flexible manipulator an estimated mapping between an end-effector movement and a plurality of values representing movement of at least one actuator, measuring an actual end-effector movement and an actual movement of the at least one actuator, and, based on the measuring, updating the estimated mapping while the flexible manipulator is active such that the mapping is adapted to the present environment of the flexible manipulator.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: November 8, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael Yip, David B. Camarillo
  • Method for regulating protein function in cells using synthetic small molecules
    Patent number: 9487787
    Abstract: Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: November 8, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas J. Wandless, Laura Anne Banaszynski, Mari Iwamoto, Lystranne Alysia Maynard, Ling-Chun Chen
  • Administration of FGF9 for treatment of anxiety
    Patent number: 9486499
    Abstract: The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: November 8, 2016
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Huda Akil, Stanley J. Watson, Cortney Turner
  • Selective stimulation to modulate the sympathetic nervous system
    Patent number: 9486633
    Abstract: Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: November 8, 2016
    Assignees: The Board of Trustees of the Leland Stanford Junior University, St. Jude Medical Luxembourg Holdings SMI S.A.R.L. (“SJM LUX SMI”)
    Inventors: Jeffery M. Kramer, Daniel H. Kim, Mir A. Imran
  • Type-Agnostic RF Signal Representations
    Publication number: 20160320854
    Abstract: This document describes techniques and devices for type-agnostic radio frequency (RF) signal representations. These techniques and devices enable use of multiple different types of radar systems and fields through type-agnostic RF signal representations. By so doing, recognition and application-layer analysis can be independent of various radar parameters that differ between different radar systems and fields.
    Type: Application
    Filed: April 29, 2016
    Publication date: November 3, 2016
    Applicants: Google Inc., The Board Of Trustees Of The Leland Stanford Junior University
    Inventors: Jaime Lien, Patrick M. Amihood, Ivan Poupyrev
  • RF-Based Micro-Motion Tracking for Gesture Tracking and Recognition
    Publication number: 20160320853
    Abstract: This document describes techniques for radio frequency (RF) based micro-motion tracking. These techniques enable even millimeter-scale hand motions to be tracked. To do so, radar signals are used from radar systems that, with conventional techniques, would only permit resolutions of a centimeter or more.
    Type: Application
    Filed: April 29, 2016
    Publication date: November 3, 2016
    Applicants: Google Inc., The Board Of Trustees Of The Leland Stanford Junior University
    Inventors: Jaime Lien, Erik M. Olson, Patrick M. Amihood, Ivan Poupyrev
  • Method to induce and expand therapeutic alloantigen-specific human regulatory T cells in large-scale
    Patent number: 9480715
    Abstract: Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4+CD25? T cells by using CD40-activated B cells. The regulatory T cells can be human T cells. In one embodiment, the alloantigen-specific human regulatory T cells can be CD4highCD25+Foxp3+ regulatory T cells.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: November 1, 2016
    Assignees: VERSITECH LIMITED, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Wenwei Tu, Yu-Lung Lau, David Bram Lewis
  • Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy
    Patent number: 9480741
    Abstract: Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: November 1, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Paolo Francesco Fabene, Eugene C. Butcher, Gabriela Constantin
  • Modulation of synaptic maintenance
    Patent number: 9480658
    Abstract: C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including treating and preventing neurodegenerative diseases such as Alzheimer's disease.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: November 1, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ben A. Barres, Alexander H. Stephan, Beth A. Stevens
  • METHODS AND SYSTEMS FOR BEAM INTENSITY-MODULATION TO FACILITATE RAPID RADIATION THERAPIES
    Publication number: 20160310764
    Abstract: Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and shaping/intensity-modulation.
    Type: Application
    Filed: March 11, 2016
    Publication date: October 27, 2016
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: VINOD BHARADWAJ, VALERY A. DOLGASHEV, REBECCA FAHRIG, BILLY WISEMAN LOO, PETER G. MAXIM, SAMI TANTAWI, CECILE LIMBORG, LUDOVIC NICOLAS
  • Low power programmable image processor
    Patent number: 9477999
    Abstract: A convolution image processor includes a load and store unit, a shift register unit, and a mapping unit. The load and store unit is configured to load and store image pixel data and allow for unaligned access of the image pixel data. The shift register is configured to load and store at least a portion of the image pixel data from the load and store unit and concurrently provide access to each image pixel value in the portion of the image pixel data. The mapping unit is configured to generate a number of shifted versions of image pixel data and corresponding stencil data from the portion of the image pixel data, and concurrently perform one or more operations on each image pixel value in the shifted versions of the portion of the image pixel data and a corresponding stencil value in the corresponding stencil data.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: October 25, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Rehan Hameed, Wajahat Qadeer, Christoforos Kozyrakis, Mark A. Horowitz
  • Imaging arrangements and methods therefor
    Patent number: 9479685
    Abstract: Image data is processed to facilitate focusing and/or optical correction. According to an example embodiment of the present invention, an imaging arrangement collects light data corresponding to light passing through a particular focal plane. The light data is collected using an approach that facilitates the determination of the direction from which various portions of the light incident upon a portion of the focal plane emanate from. Using this directional information in connection with value of the light as detected by photosensors, an image represented by the light is selectively focused and/or corrected.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: October 25, 2016
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Yi-Ren Ng, Patrick Hanrahan, Marc S. Levoy, Mark A. Horowitz
  • Use of FK506 for the treatment of pulmonary arterial hypertension
    Patent number: 9474745
    Abstract: A method of reducing pulmonary arterial hypertension in a mammal that employs FK506 is provided. In certain embodiments, the method comprises administering FK506 to a mammal having pulmonary arterial hypertension associated with defective MBPR2 signaling at a dosage sufficient to reduce blood pressure in the pulmonary artery of the mammal.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: October 25, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Edda Spiekerkoetter, Marlene Rabinovitch, Philip A. Beachy, David Solow-Cordero