Abstract: Apparatus and methods for monitoring emissions from a borehole to determine the composition of earthen material removed from the borehole are described. Monitoring can be done in real time as the borehole is being deepened with a millimeter-wave drilling beam. The present technology can monitor in real-time the elemental composition of the earthen materials (e.g., rock, minerals, crystals, metals, etc.) in a borehole created by a directed-energy beam that melts and vaporizes the earthen material materials in its path. Using a continuous emissions monitor (CEM) in combination with directed-energy excavation of a borehole enables rapid surveying of the subsurface for precious and commercial metals.

Abstract: Optical and electronic processors for calculating second-order and higher-order polynomials are described. A photonic processor can include an optical matrix multiplying unit OMMU that can perform vector-matrix multiplication. A portion of the inputs to the OMMU can be fed forward to combine with outputs from the OMMU when calculating polynomials. The described apparatus can also be used for probabilistic computing and polynomial combinatorial optimization.

Abstract: This disclosure is directed to a targeted delivery vehicle that can deliver a cargo to a cell of interest. The targeted delivery vehicle has a fusogen and a targeting domain which are embedded in a lipid bilayer membrane that forms a vesicle, and a cargo within the vesicle. The disclosure is also directed to methods for targeted delivery of cargo using the targeted delivery vehicle described herein.

Abstract: Described herein are systems and techniques for estimating a shape of a structure undergoing dynamic stress. In some embodiments, a method includes: for each of a plurality of nodes distributed along a length of the structure, obtaining, from an accelerometer located at the node, a tilt angle corresponding to an angle between a local axis of the structure and a direction of gravity; calculating, by a microcontroller, vertical displacements between adjacent pairs of the plurality of nodes using the respective tilt angles obtained for the adjacent pairs; and calculating, by the microcontroller, a depth of each of the plurality of nodes relative to a proximal end of the structure by adding the vertical displacements calculated for adjacent pairs of the plurality of nodes between the node and the proximal end of the structure.

Abstract: The present disclosure provides immunomodulatory fusion proteins comprising a collagen-binding domain operably linked to an immunomodulatory domain. The disclosure also features compositions and methods of using the same, for example, to treat cancer.

Abstract: The present invention provides for methods to obtain multiple information-rich samples at different time points from the same cell while minimally disrupting the cell. The subject matter disclosed herein is generally related to nucleic acid constructs for continuous monitoring of live cells. Specifically, the subject matter disclosed herein is directed to nucleic acid constructs that encode a fusion protein and a construct RNA sequence that induce live cells to self-report cellular contents while maintaining cell viability. The present invention may be used to monitor gene expression in single cells while maintaining cell viability.

Abstract: The present invention relates to the use of a Raman spectral signature of nitrate, as a biomarker for an early, real-time diagnosis of nitrogen status in growing plants in a non-invasive or non-destructive way in order to detect nitrogen deficiency before the onset of any visible symptoms. The early, real-time diagnosis of nitrogen deficiency in plants makes it possible to correct nitrogen deficiency for the avoidance of negative effects on the yield and biomass of growing plants or leafy vegetables.

Abstract: The use of elongated nanostructures in separators and associated devices and methods, including devices and methods for energy storage and/or use, are generally described. According to certain embodiments, the elongated nanostructures can extend from a first solid substrate to a second solid substrate. In some embodiments, the nanostructures penetrate a surface of the first solid substrate (e.g., a first electrode) and/or a surface of the second solid substrate (e.g., a second electrode). The elongated nanostructures can, according to certain embodiments, provide structural reinforcement between two substrates (e.g., between two electrodes) while maintaining electronic insulation between the two substrates.

Abstract: The present disclosure is related to sensors, such as structural sensors, and related systems and methods.

Abstract: Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).

Abstract: An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate.

Abstract: Techniques Nuc-seq, Div-Seq, and Dronc-Seq are allow for unbiased analysis of any complex tissue. Nuc-Seq, a scalable single nucleus RNA-Seq method, can sensitively identify closely related cell types, including within the adult hippocampus. Div-seq combines Nuc-Seq with EdU-mediated labeling of proliferating cells, allowing tracking of transcriptional dynamics of newborn neurons in an adult neurogenic region in the hippocampus. Dronc-Seq uses a microfluidic device to co-encapsulate individual nuclei in reverse emulsion aqueous droplets in an oil medium together with one uniquely barcoded mRNA-capture bead.

Abstract: Compositions of retroviruses and methods of using the same for gene delivery are disclosed, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.

Abstract: The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Abstract: Drawn polymer fibers have internal channels running, at least partially, through the length of the fibers. These fibers may be configured to for use as thermal isolators that can thermally isolate material at the central core of the fiber from the outside environment. In such instances, the channels may be used as insulating channels and/or a heating or cooling fluid can be pumped through the channels to maintain the temperature of the material at the inner core. As another application, the fibers may be used as recuperative, regenerative, parallel-flow, counter-flow, cross-flow or condenser/evaporator heat exchangers. In this case, the channels may be used to direct fluid flow. The fiber may allow for the exchange of heat between fluids in the channels.

Abstract: Explainable propaganda detection is provided by parsing each sentence of a plurality of sentences in an article for structural details; identifying, via a machine learning model, dimensional features across the plurality of sentences based on the structural details; identifying, via the machine learning model, a propagandizing tactic demonstrated in each sentence of the plurality of sentences based a covariance score to the propagandizing tactic and the plurality of dimensional features identified for a given sentence; and displaying, in a user interface that includes the article, propaganda labels corresponding to the propagandizing tactic identified for each sentence of the plurality of sentences.

Abstract: Described is a partitioned cable joint comprising a plurality of physically distributed joint elements with the plurality of joint elements taken together defining a joint length. Joint elements may have a first mounting region having a shape selected to accept one petal of superconducting cable and a second mounting region having a shape selected to accept one petal of a second conductor.

Abstract: Systems and methods for determining a density of a particle suspected of having been exposed to a therapeutic agent are generally described.

Abstract: Systems and methods for determining a property (e.g., density) of a particle (e.g., a cell) are generally described.

Abstract: In some aspects, the present disclosure provides methods and compositions for isothermal low temperature amplification of target polynucleotides, and detection thereof.