Patents Assigned to The Massachusetts Institute Technology
  • Reducing leakage current in semiconductor devices
    Patent number: 9911813
    Abstract: A semiconductor device includes a first region having a first semiconductor material and a second region having a second semiconductor material. The second region is formed over the first region. The semiconductor device also includes a current blocking structure formed in the first region between first and second terminals of the semiconductor device. The current blocking structure is configured to reduce current flow in the first region between the first and second terminals.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: March 6, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Bin Lu, Elison de Nazareth Matioli, Tomas Apostol Palacios
  • Articles and methods comprising persistent carbenes and related compositions
    Patent number: 9908901
    Abstract: Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: March 6, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Aleksandr V. Zhukhovitskiy
  • Microstructure synthesis by flow lithography and polymerization
    Patent number: 9910352
    Abstract: In a method for synthesizing polymeric microstructures, a monomer stream is flowed, at a selected flow rate, through a fluidic channel. At least one shaped pulse of illumination is projected to the monomer stream, defining in the monomer stream a shape of at least one microstructure corresponding to the illumination pulse shape while polymerizing that microstructure shape in the monomer stream by the illumination pulse. An article of manufacture includes a non-spheroidal polymeric microstructure that has a plurality of distinct material regions.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: March 6, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick Seamus Doyle, Daniel Colin Pregibon, Dhananjay Dendukuri
  • Quick-release adhesive tapes
    Patent number: 9907704
    Abstract: Methods and compositions for securing to and removing adhesive tapes from substrates, e.g., delicate substrates such as skin, are described. The methods include providing an adhesive tape comprising an adhesive layer and a support layer in contact with the adhesive layer. A first adhesion level between the adhesive layer and the support layer is, or can be controlled to be, less than a second adhesion level between the adhesive layer and the substrate. The methods further include applying the adhesive tape to the substrate by contacting the adhesive layer to the substrate while the support layer remains in contact with the adhesive layer; and removing the support layer from the substrate by separating the support layer from the adhesive layer.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: March 6, 2018
    Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
    Inventors: Bryan Laulicht, Jeffrey M. Karp, Robert S. Langer
  • Extruder feed system
    Patent number: 9912001
    Abstract: Extruder feed system. The system includes a pair of spaced-apart, internally and oppositely threaded rotatable elements for receiving and engaging a plastic filament material. An electric motor rotates the rotatable elements in opposite directions thereby to drive the filament into a liquefier chamber for subsequent discharge through a nozzle. The system provides very accurate layer-by-layer build up.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: March 6, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Alfonso Alexander Perez, Christopher Michael Haid, Mateo Pena Doll, Forrest W. Pieper
  • SOLID PHASE PEPTIDE SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS
    Publication number: 20180057525
    Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
    Type: Application
    Filed: May 22, 2017
    Publication date: March 1, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
  • LITHIUM HYDROGEN TITANATE Li-H-Ti-O MATERIAL AND METHOD FOR MAKING THE SAME
    Publication number: 20180062163
    Abstract: A lithium hydrogen titanate Li—H—Ti—O material includes Li, H, Ti, and O elements, wherein a mass percentage of Li is in a range from about 3% to about 12%, a mass percentage of H is in a range from about 0.1% to about 8%, a mass percentage of Ti is in a range from about 46% to about 56%, and a mass percentage of O is in a range from about 28% to about 50%. A lithium ion battery and a method for making the lithium hydrogen titanate Li—H—Ti—O material are also disclosed.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 1, 2018
    Applicants: TSINGHUA UNIVERSITY, Massachusetts Institute of Technology
    Inventors: Zi-Long Tang, Shi-Tong Wang, Zhong-Tai Zhang, Ju Li
  • MECHANOCHEMICAL SYNTHESIS OF IPTYCENES
    Publication number: 20180057443
    Abstract: Methods for mechanochemically synthesizing compositions comprising bridged bicyclic-based compounds such as iptycene-based compounds are generally provided. In some cases, two or more polycyclic aromatic hydrocarbons may be mechanochemically reacted such that the product comprises the bridged bicyclic-based compound. In some embodiments, the product (e.g., the bridged bicyclic compound) may comprise two or more [2.2.2] bicyclic cores. In certain embodiments, the mechanochemical reactions described herein may produce higher order bridged bicyclic-based compounds such as oligoiptcyenes or poly-iptycenes. In certain embodiments, the bridged bicyclic based compound comprises a molecular cage.
    Type: Application
    Filed: August 26, 2016
    Publication date: March 1, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Yanchuan Zhao, Silvia Veleirinho de Oliveira Rocha
  • Near infrared fluorescent single walled carbon nanotubes as tissue localizable biosensors
    Patent number: 9901295
    Abstract: A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: February 27, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Nicole M. Iverson, Michael S. Strano, Nigel F. Reuel, Thomas P. McNicholas
  • Mitigating leaks in membranes
    Patent number: 9901879
    Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: February 27, 2018
    Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum & Minerals
    Inventors: Rohit N. Karnik, Suman Bose, Michael S. H. Boutilier, Nicolas G. Hadjiconstantinou, Tarun Kumar Jain, Sean C. O'Hern, Tahar Laoui, Muataz A. Atieh, Doojoon Jang
  • Formation of core-shell fibers and particles by free surface electrospinning
    Patent number: 9903050
    Abstract: Disclosed are methods that utilize the differences in physical properties between two coating fluids to form core-shell particles or core-shell fibers by coaxial free-surface electrospinning. The methods are able to achieve higher productivity than known methods, and are tunable. Nonwoven fiber mats of electrospun fibers have garnered much scientific and commercial interest in recent years due to their unique properties, such as their high porosity, high surface area and small diameter fibers.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: February 27, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Keith M. Forward, Gregory C. Rutledge
  • Method and apparatus for a porous electrospray emitter
    Patent number: 9905392
    Abstract: An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. The body can have a pore size gradient that decreases from the base of the body to the tip of the body, such that the at least one of an ionic liquid or room-temperature molten salt is capable of being transported through capillarity from the base to the tip.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: February 27, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Paulo C. Lozano, Steven Mark Arestie
  • Systems and methods for the synthesis of high thermoelectric performance doped-SnTe materials
    Patent number: 9905744
    Abstract: A thermoelectric composition comprising tin (Sn), tellurium (Te) and at least one dopant that comprises a peak dimensionless figure of merit (ZT) of 1.1 and a Seebeck coefficient of at least 50 ?V/K and a method of manufacturing the thermoelectric composition. A plurality of components are disposed in a ball-milling vessel, wherein the plurality of components comprise tin (Sn), tellurium (Te), and at least one dopant such as indium (In). The components are subsequently mechanically and thermally processed, for example, by hot-pressing. In response to the mechanical-thermally processing, a thermoelectric composition is formed, wherein the thermoelectric composition comprises a dimensionless figure of merit (ZT) of the thermoelectric composition is at least 0.8, and wherein a Seebeck coefficient of the thermoelectric composition is at least 50 ?V/K at any temperature.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: February 27, 2018
    Assignees: UNIVERSITY OF HOUSTON SYSTEM, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Zhifeng Ren, Qian Zhang, Gang Chen
  • Method and system for determining the prognosis of a patient suffering from pulmonary embolism
    Patent number: 9905002
    Abstract: A system for determining the prognosis of a patient suffering from pulmonary embolism is provided. The system may include at least one computer system configure to receive patient specific data regarding his pulmonary embolism status. The at least one computer system may be further configured to create a model of the patient's heart, with at least information of the two ventricles, and to determine the ratio of sizes of the ventricles. The system will then report such ratio to the clinician or report a risk index of clinical outcome for such patient.
    Type: Grant
    Filed: November 27, 2014
    Date of Patent: February 27, 2018
    Assignees: UNIVERSIDAD POLITÉCNICA DE MADRID, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, BRIGHAM AND WOMEN'S HOSPITAL
    Inventors: Germán González Serrano, Daniel Jiménez Carretero, Frank John Rybicki, María J. Ledesma Carbayo, Sara Rodríguez López, Raúl San José Estépar
  • Sodium transition metal oxide electroactive compounds
    Patent number: 9905852
    Abstract: Embodiments related to electroactive compounds, their methods of manufacture, and use are described. In one embodiment, an electroactive compound may include Na(FeaX1-a)O2. X includes at least one of Ti, V, Cr, Mn, Co, Ni, and a is greater than 0 and less than or equal to 0.4. In another embodiment, an electroactive compound may include Na(MnwFexCoyNiz)O2, where w, x, y, and z are greater than 0. Further, a sum of w, x, y, and z is equal to 1 in some cases.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: February 27, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Xin Li, Gerbrand Ceder
  • Enterobactin conjugates and uses thereof
    Patent number: 9902986
    Abstract: The present invention provides novel enterobactin-cargo conjugates, such as compounds of Formula (I), and salts thereof, where X is the cargo and may be an antibiotic, a fluorophore, or biotin. The present invention also provides complexes, compositions, kits, and methods that involve the compounds of Formula (I) and are useful in delivering a cargo to a bacterium, treating a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, preventing a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, inhibiting the growth of or killing a bacterium, or determining the concentration of a bacterium in a biological sample. In certain embodiments, the bacterium is a Gram-negative bacterium.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: February 27, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Elizabeth Marie Nolan, Tengfei Zheng, Phoom Chairatana
  • Full spectrum anti-dengue antibody
    Patent number: 9902764
    Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: February 27, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Kannan Tharakaraman
  • Self-healing liquid/solid state battery
    Patent number: 9905888
    Abstract: A battery system that exchanges energy with an external device is provided. The battery system includes a positive electrode having a first metal or alloy, a negative electrode having a second metal or alloy, and an electrolyte including a salt of the second metal or alloy. The positive electrode, the negative electrode, and the electrolyte are in a liquid phase at an operating temperature during at least one portion of operation. The positive electrode is entirely in a liquid phase in one charged state and includes a solid phase in another charged state. The solid phase of the positive electrode includes a solid intermetallic formed by the first and the second metals or alloys. Methods of storing electrical energy from an external circuit using such a battery system are also provided.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: February 27, 2018
    Assignees: Massachusetts Institute of Technology, Total S.A., Total Energies Nouvelles Activites USA
    Inventors: Paul J. Burke, Brice H. V. Chung, Satyajit R. Phadke, Xiaohui Ning, Donald R. Sadoway
  • MEDICAL DEVICES AND IMPLEMENTS WITH LIQUID-IMPREGNATED SURFACES
    Publication number: 20180050133
    Abstract: Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween. The impregnating liquid fills spaces between said solid features, the surface stably contains the impregnating liquid between the solid features, and the impregnating liquid is substantially held in place between the plurality of solid features regardless of orientation of the surface.
    Type: Application
    Filed: March 31, 2017
    Publication date: February 22, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: J. David Smith, Rajeev Dhiman, Adam T. Paxson, Christopher J. Love, Brian R. Solomon, Kripa K. Varanasi
  • Multi-tailed lipids and uses thereof
    Patent number: 9895443
    Abstract: The present invention provides multi-tailed lipid compounds, and salts and stereoisomers thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, plasmid DNA, small molecule, protein, peptide). The present invention also provides methods, and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases (e.g., liver diseases), respiratory diseases (e.g., lung diseases), painful conditions, psychiatric disorders, metabolic disorders, and spleen diseases.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: February 20, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Akinleye C. Alabi, Kevin Thomas Love, Daniel Griffith Anderson, Robert S. Langer